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Details

Stereochemistry RACEMIC
Molecular Formula C17H22NOS2.Br
Molecular Weight 400.399
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIMEPIDIUM BROMIDE

SMILES

C[N+]1(C)CC(=C(c2cccs2)c3cccs3)CC(C1)OC.[Br-]

InChI

InChIKey=QTSXMEPZSHLZFF-UHFFFAOYSA-M
InChI=1S/C17H22NOS2.BrH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula C17H22NOS2
Molecular Weight 320.4955
Charge 1
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Molecular Formula BrH
Molecular Weight 80.9115
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Timepidium bromide is a quaternary ammonium antimuscarinic used for the symptomatic treatment of visceral spasms. It is a muscarinic antagonist.

CNS Activity

Curator's Comment:: Timepidium does not cross the blood–brain barrier

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Sesden

Approved Use

Visceral spasms
PubMed

PubMed

TitleDatePubMed
Eosinophilic pustular folliculitis induced by allopurinol and timepidium bromide.
2002
Multiple granulomatous inflammation in the minor salivary glands: a proposed new entity, allergic granulomatous sialadenitis.
2004 Nov
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Patents

Sample Use Guides

Adult Dosage: 30mg x 3 times a day.
Route of Administration: Oral
In Vitro Use Guide
Timepidium inhibited dose-dependently the contraction of isolated guinea pig gallbladder evoked by stimulation at 5 Hz. The mean dose producing a 50 % decrease in the electrically induced contraction (ID50 value) was 2.4 x 10(-8) g/ml. Timepidium (10(-6) g/ml) also inhibited, for the most part, the contraction induced by stimulation at 30 Hz.
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:40:22 UTC 2021
Edited
by admin
on Sat Jun 26 04:40:22 UTC 2021
Record UNII
8R9E4766V4
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TIMEPIDIUM BROMIDE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
3-(DI-2-THIENYLMETHYLENE)-5-METHOXY-1,1-DIMETHYL-PIPERIDINIUM BROMIDE
Systematic Name English
TIMEPIDIUM BROMIDE [WHO-DD]
Common Name English
TIMEPIDIUM BROMIDE [MART.]
Common Name English
TIMEPIDIUM BROMIDE [MI]
Common Name English
TIMEPIDIUM BROMIDE [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QA03AB19
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
WHO-ATC A03AB19
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
NCI_THESAURUS C29704
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
Code System Code Type Description
CAS
35035-05-3
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
DRUG BANK
DBSALT002528
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
ChEMBL
CHEMBL1865135
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
PUBCHEM
160243
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
FDA UNII
8R9E4766V4
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
MERCK INDEX
M10869
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY Merck Index
NCI_THESAURUS
C81544
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
EPA CompTox
35035-05-3
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
INN
3411
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
WIKIPEDIA
TIMEPIDIUM BROMIDE
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
EVMPD
SUB11064MIG
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
MESH
C001739
Created by admin on Sat Jun 26 04:40:22 UTC 2021 , Edited by admin on Sat Jun 26 04:40:22 UTC 2021
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
PARENT -> SALT/SOLVATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY