JNJ-42165279

Investigational

FC1(F)OC2=CC=C(CN3CCN(CC3)C(=O)NC4=C(Cl)C=CN=C4)C=C2O1

InChIKey=YWGYNGCRVZLMCS-UHFFFAOYSA-N

InChI=1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Anandamide amidohydrolase 26 Target ID: CHEMBL2243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26713105 \| https://patents.google.com/patent/WO2011139951A1	Inhibitor 8297		70.0 nM [IC50]

PubMed

Title	Date	PubMed
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.	2015 Dec 10	26713105
Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers.	2018 Jul	29575526

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:56:38 GMT 2023` Edited by `admin` on `Sat Dec 16 01:56:38 GMT 2023`
Record UNII	AH2E5UQ11Y
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

JNJ-42165279

Common Name

English

1-PIPERAZINECARBOXAMIDE, N-(4-CHLORO-3-PYRIDINYL)-4-((2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

54576693