JNJ-42165279

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H17ClF2N4O3
Molecular Weight	410.802
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of JNJ-42165279

Structure Search

SMILES

FC1(F)OC2=CC=C(CN3CCN(CC3)C(=O)NC4=C(Cl)C=CN=C4)C=C2O1

InChI

InChIKey=YWGYNGCRVZLMCS-UHFFFAOYSA-N

InChI=1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26)

HIDE SMILES / InChI

Molecular Formula	C18H17ClF2N4O3
Molecular Weight	410.802
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Anandamide amidohydrolase 26 Target ID: CHEMBL2243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26713105 \| https://patents.google.com/patent/WO2011139951A1	Inhibitor 8297		70.0 nM [IC50]

PubMed

PubMed

Title	Date	PubMed

Patents

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:56:38 UTC 2023` Edited by `admin` on `Sat Dec 16 01:56:38 UTC 2023`
Record UNII	AH2E5UQ11Y
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

JNJ-42165279

Common Name

English

1-PIPERAZINECARBOXAMIDE, N-(4-CHLORO-3-PYRIDINYL)-4-((2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

54576693

Created by admin on Sat Dec 16 01:56:38 UTC 2023 , Edited by admin on Sat Dec 16 01:56:38 UTC 2023

PRIMARY

FDA UNII

AH2E5UQ11Y

Created by admin on Sat Dec 16 01:56:38 UTC 2023 , Edited by admin on Sat Dec 16 01:56:38 UTC 2023

PRIMARY

CAS

1346528-50-4

Created by admin on Sat Dec 16 01:56:38 UTC 2023 , Edited by admin on Sat Dec 16 01:56:38 UTC 2023

PRIMARY

WIKIPEDIA

JNJ-42165279

Created by admin on Sat Dec 16 01:56:38 UTC 2023 , Edited by admin on Sat Dec 16 01:56:38 UTC 2023

PRIMARY

DRUG BANK

DB15173

Created by admin on Sat Dec 16 01:56:38 UTC 2023 , Edited by admin on Sat Dec 16 01:56:38 UTC 2023

PRIMARY

EPA CompTox

DTXSID501045937

Created by admin on Sat Dec 16 01:56:38 UTC 2023 , Edited by admin on Sat Dec 16 01:56:38 UTC 2023

PRIMARY

Related Record Type Details


					Y23WF20TS1

JNJ-42165279 HYDROCHLORIDE

SALT/SOLVATE -> PARENT


					E747F394ZQ

FATTY-ACID AMIDE HYDROLASE 1

TARGET -> INHIBITOR

Interaction Type:

INHIBITOR

Amount:


					071MBK5AJN

JNJ-42165279 DIHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Related Record Type Details


					AH2E5UQ11Y

ACTIVE MOIETY

Comments:

covalently binding but slowly reversible selective inhibitor of FAAH

Qualification:

IC50

Amount: