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Details

Stereochemistry ACHIRAL
Molecular Formula C18H17ClF2N4O3.ClH
Molecular Weight 447.263
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of JNJ-42165279 HYDROCHLORIDE

SMILES

Cl.FC1(F)OC2=CC=C(CN3CCN(CC3)C(=O)NC4=C(Cl)C=CN=C4)C=C2O1

InChI

InChIKey=QXRBSEFDVGDHGV-UHFFFAOYSA-N
InChI=1S/C18H17ClF2N4O3.ClH/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15;/h1-4,9-10H,5-8,11H2,(H,23,26);1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C18H17ClF2N4O3
Molecular Weight 410.802
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
70.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.
2015 Dec 10
Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers.
2018 Jul
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 14:14:29 GMT 2023
Edited
by admin
on Sat Dec 16 14:14:29 GMT 2023
Record UNII
Y23WF20TS1
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
JNJ-42165279 HYDROCHLORIDE
Code English
1-PIPERAZINECARBOXAMIDE, N-(4-CHLORO-3-PYRIDINYL)-4-((2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
CAS
1346528-52-6
Created by admin on Sat Dec 16 14:14:30 GMT 2023 , Edited by admin on Sat Dec 16 14:14:30 GMT 2023
PRIMARY
FDA UNII
Y23WF20TS1
Created by admin on Sat Dec 16 14:14:30 GMT 2023 , Edited by admin on Sat Dec 16 14:14:30 GMT 2023
PRIMARY
PUBCHEM
67465468
Created by admin on Sat Dec 16 14:14:30 GMT 2023 , Edited by admin on Sat Dec 16 14:14:30 GMT 2023
PRIMARY
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