JNJ-42165279 DIHYDROCHLORIDE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H17ClF2N4O3.2ClH
Molecular Weight	483.724
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of JNJ-42165279 DIHYDROCHLORIDE

Structure Search

SMILES

Cl.Cl.FC1(F)OC2=CC=C(CN3CCN(CC3)C(=O)NC4=C(Cl)C=CN=C4)C=C2O1

InChI

InChIKey=JBRSFMLNQIAKFI-UHFFFAOYSA-N

InChI=1S/C18H17ClF2N4O3.2ClH/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15;;/h1-4,9-10H,5-8,11H2,(H,23,26);2*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H17ClF2N4O3
Molecular Weight	410.802
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Anandamide amidohydrolase 26 Target ID: CHEMBL2243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26713105 \| https://patents.google.com/patent/WO2011139951A1	Inhibitor 8297		70.0 nM [IC50]

PubMed

Title	Date	PubMed
Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.	2015 Dec 10	26713105
Fatty Acid Amide Hydrolase Inhibition by JNJ-42165279: A Multiple-Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers.	2018 Jul	29575526

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 14:19:42 GMT 2023` Edited by `admin` on `Sat Dec 16 14:19:42 GMT 2023`
Record UNII	071MBK5AJN
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

JNJ-42165279 DIHYDROCHLORIDE

Code

English

1-PIPERAZINECARBOXAMIDE, N-(4-CHLORO-3-PYRIDINYL)-4-((2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

Code System Code Type Description

FDA UNII

071MBK5AJN

Created by admin on Sat Dec 16 14:19:42 GMT 2023 , Edited by admin on Sat Dec 16 14:19:42 GMT 2023

PRIMARY

CAS

1346528-51-5

Created by admin on Sat Dec 16 14:19:42 GMT 2023 , Edited by admin on Sat Dec 16 14:19:42 GMT 2023

PRIMARY

PUBCHEM

54576694

Created by admin on Sat Dec 16 14:19:42 GMT 2023 , Edited by admin on Sat Dec 16 14:19:42 GMT 2023

PRIMARY

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ACTIVE MOIETY