DAFSOLIMAB SETARITOX

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 00:01:26 GMT 2025` Edited by `admin` on `Wed Apr 02 00:01:26 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG2B
Sequence Origin	MOUSE
Sequence Type	COMPLETE
Record UNII	AG8ULI6K9U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DAFSOLIMAB SETARITOX

Official Name

English

IMMUNOGLOBULIN G2A-LAMBDA, ANTI-(CD7 (CD7ANTIGEN (P41),GP40, LEU-9, TP41, TP40)), MUS MUSCULUS MONOCLONAL ANTIBODY CONJUGATED TO RICIN TOXIN A (RTA) (DAFSOLIMAB SETARITOX)

Preferred Name

English

dafsolimab setaritox [INN]

Common Name

English

IMMUNOGLOBULIN G2B, ANTI-(HUMAN CD3 ANTIGEN .EPSILON..DELTA. COMPLEX) (MUS MUSCULUS MONOCLONAL SPV-T3A .GAMMA.2B-CHAIN), DISULFIDE WITH MUS MUSCULUS MONOCLONAL SPV-T3A .KAPPA.-CHAIN, DIMER, N6-(4-(1-MERCAPTOETHYL) BENZOYL) 260-DISULFIDE WITH RICIN A CHAI

Common Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/05/317

Created by admin on Wed Apr 02 00:01:26 GMT 2025 , Edited by admin on Wed Apr 02 00:01:26 GMT 2025

Code System Code Type Description

SMS_ID

300000008869

Created by admin on Wed Apr 02 00:01:26 GMT 2025 , Edited by admin on Wed Apr 02 00:01:26 GMT 2025

PRIMARY

CAS

2361013-28-5

Created by admin on Wed Apr 02 00:01:26 GMT 2025 , Edited by admin on Wed Apr 02 00:01:26 GMT 2025

PRIMARY

NCI_THESAURUS

C175761

Created by admin on Wed Apr 02 00:01:26 GMT 2025 , Edited by admin on Wed Apr 02 00:01:26 GMT 2025

PRIMARY

INN

11489

Created by admin on Wed Apr 02 00:01:26 GMT 2025 , Edited by admin on Wed Apr 02 00:01:26 GMT 2025

PRIMARY

FDA UNII

AG8ULI6K9U

Created by admin on Wed Apr 02 00:01:26 GMT 2025 , Edited by admin on Wed Apr 02 00:01:26 GMT 2025

PRIMARY

From	To
4_133	4_193
4_23	4_87
3_133	3_193
3_23	3_87
2_376	2_434
2_270	2_330
2_147	2_202
2_135	4_213
2_22	2_96
1_376	1_434
1_270	1_330
1_238	2_238
1_235	2_235
1_232	2_232
1_229	2_229
1_147	1_202
1_135	3_213
1_22	1_96

Glycosylation Link Type	Site
N	1_306
N	2_306

Related Record Type Details


					AO2W2OFG8P

PARENT -> CONJUGATE

Amount:


					ZLW14X2D30

CD3

TARGET->LIGAND

Amount:

Related Record Type Details


					AG8ULI6K9U

DAFSOLIMAB SETARITOX

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_74] [1_326] [1_329] [1_349] [1_442] [1_447] [2_74] [2_326] [2_329] [2_349] [2_442] [2_447] [3_18] [3_52] [3_141] [3_168] [3_206] [4_18] [4_52] [4_141] [4_168] [4_206]	SITE_SPECIFIC		Amount:	UNSPECIFIED SUBSTANCE	3821597e (not in database)
AMINO ACID REMOVAL	[1_456] [2_456]	C-TERMINUS			LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1] [3_1] [4_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL