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Details

Stereochemistry ACHIRAL
Molecular Formula CHNS
Molecular Weight 59.09
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of THIOCYANIC ACID

SMILES

SC#N

InChI

InChIKey=ZMZDMBWJUHKJPS-UHFFFAOYSA-N
InChI=1S/CHNS/c2-1-3/h3H

HIDE SMILES / InChI
Molecular Formula CHNS
Molecular Weight 59.09
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Thiocyanic acid, also known as hydrogen thiocyanate, is a hydracid that is cyanic acid in which the oxygen is replaced by a sulfur atom. It has a role as an Escherichia coli metabolite. It is a hydracid, a one-carbon compound and an organosulfur compound. It is a conjugate acid of a thiocyanate. It is a tautomer of an isothiocyanic acid. In the past, thiocyanate was used therapeutically to treat severe hypertension, but the results of this therapy were inconsistent from clinic to clinic, and even within a single study. Thiocyanate is believed to play a role in an endogenous antibacterial system (lactoperoxidase/thiocyanate/hydrogen peroxide system) present in milk. It has been added commercially to some milk preparations as an antibacterial agent.

Approval Year

1961
146
PubMed

PubMed

TitleDatePubMed
Application of potassium dichromate and iron-thiocyanate in the spectrophotometric investigations of phenothiazines.
2001 Aug
4-(Methylthio)-3-butenyl isothiocyanate, a principal antimutagen in daikon (Raphanus sativus; Japanese white radish).
2001 Dec
In vitro antioxidant properties of dantrolene sodium.
2001 Dec
Novel tropane-based irreversible ligands for the dopamine transporter.
2001 Dec 6
[Detection of Immunoglobulin light chain restriction of mucosa-associated lymphoid tissue type gastric lymphoma using mRNA in situ hybridization].
2001 Feb
Analgesic activity and opioid receptor selectivity of stereoisomers of ohmefentanyl isothiocyanate.
2001 Jul 27
Demonstration of the pH sensitive binding of multivalent carbohydrate ligands to immobilized Shiga-like toxin 1 B subunits.
2001 Nov
Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency.
2001 Nov
Oligothiophene isothiocyanates as a new class of fluorescent markers for biopolymers.
2001 Nov 28
Effect of intrapulpal pressure simulation in vitro on shear bond strengths and hybrid layer formation.
2001 Oct
Isothiocyanates: mechanism of cancer chemopreventive action.
2002 Apr
On-line solid phase extraction with polyurethane foam: trace level spectrophotometric determination of iron in natural waters and biological materials.
2002 Aug
Fluorescent somatostatin receptor probes for the intraoperative detection of tumor tissue with long-wavelength visible light.
2002 Aug
Application of fluorescently labelled lectins for the visualization and biochemical characterization of polysaccharides in biofilms of Pseudomonas aeruginosa.
2002 Aug
Photochemistry of N-isopropoxy-substituted 2(1H)-pyridone and 4-p-tolylthiazole-2(3H)-thione: alkoxyl-radical release (spin-trapping, EPR, and transient spectroscopy) and its significance in the photooxidative induction of DNA strand breaks.
2002 Aug 23
Isolation of three main sericin components from the cocoon of the silkworm, Bombyx mori.
2002 Dec
Detection of charge movements in ion pumps by a family of styryl dyes.
2002 Feb 1
A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway.
2002 Feb 1
Calcium dicaesium silver thiocyanate dihydrate.
2002 Jan
Dicaesium silver zinc thiocyanate, Cs2[AgZn(SCN)5].
2002 Jan
Spatial organization of the glucosinolate-myrosinase system in brassica specialist aphids is similar to that of the host plant.
2002 Jan 22
Evaluation of the mixed aggregate method as an alternative to the bismuth active substances and cobalt thiocyanate active substances procedures for the determination of nonionic surfactants in raw and treated sewage.
2002 Jan-Feb
Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses.
2002 Jul 12
Bulk weak ferromagnet in ferrimagnetic chains of organic-inorganic hybrid materials based on BDH-TTP and paramagnetic thiocyanato complex anions: (BDH-TTP)[M(isoq)(2)(NCS)(4)], M = Cr(III), Fe(III).
2002 Jul 15
Temperature dependence of the crystal lattice organization of coordination compounds involving nitronyl nitroxide radicals: a magnetic and structural investigation.
2002 Jul 15
Interactions among membrane and soluble components of the flagellar export apparatus of Salmonella.
2002 Jul 30
Turbidimetric determination of chloride in different types of water using a single sequential injection analysis system.
2002 Jun
Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids.
2002 Jun 27
Synthesis of (+)-cis-N-(4-isothiocyanatobenzyl)-N-normetazocine, an isothiocyanate derivative of N-benzylnormetazocine as acylant agent for the sigma(1) receptor.
2002 Jun 6
C-terminal sequence analysis of peptides using triphenylgermanyl isothiocyanate.
2002 Mar 1
Glucosinolate breakdown products as insect fumigants and their effect on carbon dioxide emission of insects.
2002 Mar 22
[Method of orienting immobilized proteins on gold surface sensory modified with rhodanide].
2002 Mar-Apr
A convenient synthesis and hepatoprotective activity of imidazo[1,2-c]pyrimido[5,4-e]pyrimidine, tetraazaacenaphthene and tetraazaphenalene from cyclic ketene aminals through tandem addition-cyclization reactions.
2002 May
High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.
2002 May 15
Synthesis and characterization of cobalt and nickel chelates of 5-dimethylaminomethyl-2-thiouracil and their evaluation as antimicrobial and anticancer agents.
2002 May 21
Performance evaluation of the phosphorescent porphyrin label: solid-phase immunoassay of alpha-fetoprotein.
2002 Nov 15
Syntheses of hydantocidin and C-2-thioxohydantocidin.
2002 Nov 19
[Telomerase gene antisense oligodeoxynucleotide down-regulates telomerase activity in HL-60 cells].
2002 Oct
Atherosclerosis in youth.
2002 Oct
Design and structural extension of a supramolecular inclusion-compound host made by the formation of dimers of isonicotinic acid and thiocyanato coordinating bridges.
2002 Oct 18
Identification of the major glucosinolate (4-mercaptobutyl glucosinolate) in leaves of Eruca sativa L. (salad rocket).
2002 Sep
Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies.
2002 Sep-Oct
Solid-phase syntheses of 1,2,4-trisubstituted urazole and thiourazole derivatives.
2002 Sep-Oct
Radiolabeling morpholinos with 90Y, 111In, 188Re and 99mTc.
2003 Feb
Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells.
2003 Feb
Taming of a poison: biosynthesis of the NiFe-hydrogenase cyanide ligands.
2003 Feb 14
Dermorphin-based potential affinity labels for mu-opioid receptors.
2003 Jan
Synthesis of covalent probes for the radiolabeling of the cannabinoid receptor.
2003 Jan 10
Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay.
2003 Jan 6
IgG subclasses in human immune response to wild and attenuated (vaccine) Junin virus infection.
2003 Mar
Patents

Patents

03931269
9
03935195
3
03941821
4
03966801
9
03981890
3
03992432
3
04028344
11
04034107
4
04059588
4
04070372
3
04071528
4
04101546
3
04101548
4
04137310
3
04171363
3
04239708
4
04267345
3
04315020
3
04331817
3
04438126
4
04451471
5
04540693
6
04545994
3
04602961
3
04632938
3
04636516
6
04711903
3
04713382
3
04755524
3
04843100
3
04859562
7
04873072
3
04885022
3
04948887
5
04997967
3
05047411
6
05175299
4
05232936
3
05242948
3
05250567
4
05294724
5
05302592
3
05326907
3
05342838
3
05364871
4
05380735
4
05439917
3
05444080
4
05728699
3
05770758
3
05847147
3
05888940
3
06002013
3
06005129
3
06069255
3
06262059
3
06262112
3
06271392
3
06350771
5
06380422
3
06383986
4
06469054
3
06498265
3
06500850
6
06528510
4
06541423
6
06545050
3
06573278
3
06586617
6

Sample Use Guides

In Vivo Use Guide
The effects on blood pressure were reported at doses generally ranging from 1.3−4.3 mg (SCN)/kg-day, while effects on the thyroid occurred at exposure levels of ≥0.19 mg (SCN)/kg-day in healthy subjects
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:00:40 GMT 2023
Edited
by admin
on Fri Dec 15 18:00:40 GMT 2023
Record UNII
A5KWW7N91V
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
THIOCYANIC ACID
MI  
Systematic Name English
SULFOCYANIC ACID
Systematic Name English
THIOCYANIC ACID [MI]
Common Name English
HYDROGEN THIOCYANATE
Systematic Name English
Classification Tree Code System Code
WHO-ATC R01AX01
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
Code System Code Type Description
SMS_ID
100000128301
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
MESH
C026976
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
FDA UNII
A5KWW7N91V
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
EVMPD
SUB35160
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
WIKIPEDIA
THIOCYANIC ACID
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
CAS
463-56-9
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
EPA CompTox
DTXSID7047221
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
CHEBI
29200
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
MERCK INDEX
m10751
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY Merck Index
PUBCHEM
781
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
ECHA (EC/EINECS)
207-337-4
Created by admin on Fri Dec 15 18:00:40 GMT 2023 , Edited by admin on Fri Dec 15 18:00:40 GMT 2023
PRIMARY
Related Record Type Details
Structure of POTASSIUM THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of SILVER THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of ERYTHROMYCIN THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of COBALTOUS THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of AMMONIUM THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of MERCURIC THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of MAGNESIUM THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of FERROUS THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of METHENAMINE THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of ALUMINUM THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of FERRIC THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of SODIUM THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of GUANIDINE THIOCYANATE
SALT/SOLVATE -> PARENT
Structure of CALCIUM THIOCYANATE
SALT/SOLVATE -> PARENT
Related Record Type Details
Structure of THIOCYANIC ACID
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