U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula CNS.H4N
Molecular Weight 76.121
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM THIOCYANATE

SMILES

[NH4+].[S-]C#N

InChI

InChIKey=SOIFLUNRINLCBN-UHFFFAOYSA-N
InChI=1S/CHNS.H3N/c2-1-3;/h3H;1H3

HIDE SMILES / InChI
Molecular Formula CHNS
Molecular Weight 59.09
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Thiocyanic acid, also known as hydrogen thiocyanate, is a hydracid that is cyanic acid in which the oxygen is replaced by a sulfur atom. It has a role as an Escherichia coli metabolite. It is a hydracid, a one-carbon compound and an organosulfur compound. It is a conjugate acid of a thiocyanate. It is a tautomer of an isothiocyanic acid. In the past, thiocyanate was used therapeutically to treat severe hypertension, but the results of this therapy were inconsistent from clinic to clinic, and even within a single study. Thiocyanate is believed to play a role in an endogenous antibacterial system (lactoperoxidase/thiocyanate/hydrogen peroxide system) present in milk. It has been added commercially to some milk preparations as an antibacterial agent.

Approval Year

1961
146
PubMed

PubMed

TitleDatePubMed
Peroxidative metabolism of beta2-agonists salbutamol and fenoterol and their analogues.
2009-06
IgG subclasses in human immune response to wild and attenuated (vaccine) Junin virus infection.
2003-03
Taming of a poison: biosynthesis of the NiFe-hydrogenase cyanide ligands.
2003-02-14
Radiolabeling morpholinos with 90Y, 111In, 188Re and 99mTc.
2003-02
Development of isothiocyanate-enriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells.
2003-02
Circulating bile salt-dependent lipase originates from the pancreas via intestinal transcytosis.
2003-02
Synthesis and evaluation of potential affinity labels derived from endomorphin-2.
2003-02
Synthesis of covalent probes for the radiolabeling of the cannabinoid receptor.
2003-01-10
Effects of garden and water cress juices and their constituents, benzyl and phenethyl isothiocyanates, towards benzo(a)pyrene-induced DNA damage: a model study with the single cell gel electrophoresis/Hep G2 assay.
2003-01-06
Anion selectivity by the sodium iodide symporter.
2003-01
Dermorphin-based potential affinity labels for mu-opioid receptors.
2003-01
Isolation of three main sericin components from the cocoon of the silkworm, Bombyx mori.
2002-12
Urinary excretion of dithiocarbamates and self-reported Cruciferous vegetable intake: application of the 'method of triads' to a food-specific biomarker.
2002-12
Asymmetrical, water-soluble phthalocyanine dyes for covalent labeling of oligonucleotides.
2002-11-21
One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides.
2002-11-19
Syntheses of hydantocidin and C-2-thioxohydantocidin.
2002-11-19
Performance evaluation of the phosphorescent porphyrin label: solid-phase immunoassay of alpha-fetoprotein.
2002-11-15
Oligothiophene isothiocyanates as fluorescent markers.
2002-11-15
Surface modification of polycaprolactone membrane via aminolysis and biomacromolecule immobilization for promoting cytocompatibility of human endothelial cells.
2002-11-12
Low enzyme content in the pancreas does not reduce the severity of acute pancreatitis induced by bile-pancreatic duct obstruction.
2002-11
Design and structural extension of a supramolecular inclusion-compound host made by the formation of dimers of isonicotinic acid and thiocyanato coordinating bridges.
2002-10-18
[Telomerase gene antisense oligodeoxynucleotide down-regulates telomerase activity in HL-60 cells].
2002-10
Atherosclerosis in youth.
2002-10
On the in vitro antioxidative properties of melatonin.
2002-10
Functionalized congeners of tyrosine-based P2X(7) receptor antagonists: probing multiple sites for linking and dimerization.
2002-09-19
Trifunctional conjugation reagents. Reagents that contain a biotin and a radiometal chelation moiety for application to extracorporeal affinity adsorption of radiolabeled antibodies.
2002-09-19
Solid-phase syntheses of 1,2,4-trisubstituted urazole and thiourazole derivatives.
2002-09-10
Identification of the major glucosinolate (4-mercaptobutyl glucosinolate) in leaves of Eruca sativa L. (salad rocket).
2002-09
Site specificity of metal ions in heterodinuclear complexes derived from an "end-off" compartmental ligand.
2002-08-26
Photochemistry of N-isopropoxy-substituted 2(1H)-pyridone and 4-p-tolylthiazole-2(3H)-thione: alkoxyl-radical release (spin-trapping, EPR, and transient spectroscopy) and its significance in the photooxidative induction of DNA strand breaks.
2002-08-23
Quantification of the bioadhesive properties of protein-coated PVM/MA nanoparticles.
2002-08-21
[Method of orienting immobilized proteins on gold surface sensory modified with rhodanide].
2002-08-03
On-line solid phase extraction with polyurethane foam: trace level spectrophotometric determination of iron in natural waters and biological materials.
2002-08
Fluorescent somatostatin receptor probes for the intraoperative detection of tumor tissue with long-wavelength visible light.
2002-08
Application of fluorescently labelled lectins for the visualization and biochemical characterization of polysaccharides in biofilms of Pseudomonas aeruginosa.
2002-08
Interactions among membrane and soluble components of the flagellar export apparatus of Salmonella.
2002-07-30
Bulk weak ferromagnet in ferrimagnetic chains of organic-inorganic hybrid materials based on BDH-TTP and paramagnetic thiocyanato complex anions: (BDH-TTP)[M(isoq)(2)(NCS)(4)], M = Cr(III), Fe(III).
2002-07-15
Temperature dependence of the crystal lattice organization of coordination compounds involving nitronyl nitroxide radicals: a magnetic and structural investigation.
2002-07-15
Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses.
2002-07-12
Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids.
2002-06-27
Synthesis of (+)-cis-N-(4-isothiocyanatobenzyl)-N-normetazocine, an isothiocyanate derivative of N-benzylnormetazocine as acylant agent for the sigma(1) receptor.
2002-06-06
Use of SYTOX green dye in the flow cytometric analysis of bacterial phagocytosis.
2002-06-01
Turbidimetric determination of chloride in different types of water using a single sequential injection analysis system.
2002-06
Synthesis and characterization of cobalt and nickel chelates of 5-dimethylaminomethyl-2-thiouracil and their evaluation as antimicrobial and anticancer agents.
2002-05-21
High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate.
2002-05-15
Effect of adenosine 5'-[beta,gamma-imido]triphosphate on myosin head domain movements.
2002-04
Isothiocyanates: mechanism of cancer chemopreventive action.
2002-04
Glucosinolate breakdown products as insect fumigants and their effect on carbon dioxide emission of insects.
2002-03-22
Detection of charge movements in ion pumps by a family of styryl dyes.
2002-02-01
Micronutrients and the regulation of cancerous cell growth and death: effect of sulforaphane, an isothiocyanate from broccoli.
2002
Patents

Patents

03931269
9
03935195
3
03941821
4
03966801
10
03981890
3
03992432
3
04028344
11
04034107
4
04059588
4
04070372
3
04071528
4
04101546
3
04101548
4
04137310
3
04171363
3
04239708
4
04267345
3
04315020
3
04331817
3
04438126
4
04451471
5
04540693
6
04545994
3
04602961
3
04632938
3
04636516
6
04711903
3
04713382
3
04755524
3
04843100
3
04859562
7
04873072
3
04885022
3
04948887
5
04997967
3
05047411
6
05175299
4
05232936
3
05242948
3
05250567
4
05294724
5
05302592
3
05326907
3
05342838
3
05364871
4
05380735
4
05439917
3
05444080
4
05728699
3
05770758
3
05847147
3
05888940
3
06002013
3
06005129
3
06069255
3
06262059
3
06262112
3
06271392
3
06350771
5
06380422
3
06383986
4
06469054
3
06498265
3
06500850
6
06528510
4
06541423
6
06545050
3
06573278
3
06586617
6

Sample Use Guides

In Vivo Use Guide
The effects on blood pressure were reported at doses generally ranging from 1.3−4.3 mg (SCN)/kg-day, while effects on the thyroid occurred at exposure levels of ≥0.19 mg (SCN)/kg-day in healthy subjects
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:33:48 GMT 2025
Edited
by admin
on Mon Mar 31 19:33:48 GMT 2025
Record UNII
YYL9152Z1Y
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMMONIUM THIOCYANATE
HSDB   INCI   MI   WHO-DD  
INCI  
Official Name English
NSC-31184
Preferred Name English
Ammonium thiocyanate [WHO-DD]
Common Name English
AMMONIUM THIOCYANATE [MI]
Common Name English
AMMONIUM THIOCYANATE [HSDB]
Common Name English
THIOCYANIC ACID AMMONIUM SALT (1:1)
Common Name English
THIOCYANIC ACID, AMMONIUM SALT
Common Name English
AMMONIUM SULFOCYANIDE
Systematic Name English
AMMONIUM RHODANIDE
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 68200
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
Code System Code Type Description
PUBCHEM
15666
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
ECHA (EC/EINECS)
217-175-6
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
WIKIPEDIA
AMMONIUM THIOCYANATE
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
CAS
1762-95-4
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
FDA UNII
YYL9152Z1Y
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
MERCK INDEX
m1828
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY Merck Index
NSC
31184
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
DAILYMED
YYL9152Z1Y
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
RXCUI
2109607
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
MESH
C026976
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
EPA CompTox
DTXSID3029653
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
HSDB
701
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
EVMPD
SUB12885MIG
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
SMS_ID
100000077927
Created by admin on Mon Mar 31 19:33:48 GMT 2025 , Edited by admin on Mon Mar 31 19:33:48 GMT 2025
PRIMARY
Related Record Type Details
Structure of THIOCYANIC ACID
PARENT -> SALT/SOLVATE
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966