SILVER SULFIDE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Ag.S
Molecular Weight	247.801
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[S--].[Ag+].[Ag+]

InChI

InChIKey=XUARKZBEFFVFRG-UHFFFAOYSA-N

InChI=1S/2Ag.S/q2*+1;-2

HIDE SMILES / InChI

Molecular Formula	Ag
Molecular Weight	107.8682
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HS
Molecular Weight	33.073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26897901https://www.ncbi.nlm.nih.gov/pubmed/25781988The legal airborne permissible exposure limit (PEL) is 11 mg/m^2 averaged over an 8-hour workshift.https://www.ncbi.nlm.nih.gov/pubmed/20429870https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+2930 | https://www.ncbi.nlm.nih.gov/pubmed/11294738https://www.purebio.com/assets/001/5202.pdfhttp://google.com/patents/CN102923966Bhttps://www.ncbi.nlm.nih.gov/pubmed/19278981
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/26687774 | https://clinicaltrials.gov/ct2/show/NCT01950546 | https://www.ncbi.nlm.nih.gov/pubmed/24373700

Silver Fluoride is an odorless yellow to gray solid salt with the formula AgF. Silver Fluoride has relatively few niche applications; it has been employed as a fluorination and desilylation reagent in organic synthesis and in aqueous solution as a topical caries treatment in dentistry. Multiple studies have shown silver(I) fluoride to be an effective anti-caries agent. Treatment is typically by the "atraumatic" method, in which 40% by mass aqueous silver(I) fluoride solution is applied to carious lesions, followed by sealing of the dentine with glass ionomer cement. Although the treatment is generally recognized to be safe, fluoride toxicity has been a significant clinical concern in pediatric applications, especially as some commercial preparations have had considerable silver(II) fluoride contamination in the past. Due to the instability of concentrated AgF solutions, silver diamine fluoride (Ag(NH3)2F) is now more commonly used.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cellular response to silver ion 16 Target ID: GO:0071292 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18245232	Substrate 643
tooth mineralization 16 Target ID: GO:0034505 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26897901	Substrate 643
cellular response to silver ion 16 Target ID: GO:0071292 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18245232	Substrate 643
tooth mineralization 16 Target ID: GO:0034505 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24373700	Substrate 643
cellular response to silver ion 16 Target ID: GO:0071292 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18245232	Substrate 643
cellular response to silver ion 16 Target ID: GO:0071292 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18245232	Substrate 643

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2554
Unknown 2554
Dental caries 45 Sources: https://clinicaltrials.gov/ct2/show/NCT01446107	Primary	Approved 8307	Advantage Arrest Silver Diamine Fluoride Approved Use Unknown
Dentinal hypersensitivity 16 Sources: http://health.mo.gov/living/families/oralhealth/pdf/silver-diamine-fluoride.pdf	Primary	Approved 8307	Advantage Arrest Silver Diamine Fluoride Approved Use Unknown
Dental caries 45 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26687774	Primary	Phase I 422	Unknown Approved Use Unknown
Bacterial Infections 63 Sources: https://www.purebio.com/assets/001/5202.pdf	Curative	Not Provided 505	Unknown Approved Use Unknown
Dermatophyte infection 18 Sources: http://www.prnewswire.com/news-releases/pure-bioscience-and-therapeutics-inc-expand-silver-dihydrogen-citrate-pharmaceutical-product-development-initiative-to-include-athletes-foot-nail-fungus-and-antimicrobial-skin-wash-products-55885657.html	Curative	Not Provided 505	Unknown Approved Use Unknown
Unknown 2554
Infections of the mucous membranes 16 Sources: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~Hcwr0m:1:ther	Primary	Not Provided 505	Colloidal silver iodide Approved Use Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Inflammatory conditions of the eye, ear, and nose 16 Sources: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~Hcwr0m:1:ther	Primary	Not Provided 505	Colloidal silver iodide Approved Use Solution containing 5 to 49% of colloidal silver iodide have been employed in the treatment of infections of the mucous membranes. Ointments, usually containing 5%, have been used in inflammatory conditions of the eye, ear, and nose.
Burn 39 Sources: http://reference.medscape.com/drug/silver-nitrate-343589	Palliative	Approved 8307	Unknown Approved Use Antiseptic Wound Cauterization
Ophthalmia neonatorum 16 Sources: https://www.drugs.com/monograph/silver-nitrate.html	Primary	Approved 8307	Unknown Approved Use Prophylaxis of gonococcal ophthalmia neonatorum. AAP recommends use of topical silver nitrate, povidone-iodine, or possibly erythromycin for prophylaxis of nongonococcal nonchlamydial conjunctivitis in neonates, ideally administered shortly after birth.

PubMed

Title	Date	PubMed
Lack of genotoxicity of silver iodide in the SCE assay in vitro, in vivo, and in the Ames/microsome test.	1998	10052565
A chemically intelligent antimicrobial coating for urologic devices.	2000 Feb	10735572
New disinfection and sterilization methods.	2001 Mar-Apr	11294738
Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses.	2005 Mar	15761405
Photocatalytic degradation of pathogenic bacteria with AgI/TiO2 under visible light irradiation.	2007 Apr 24	17373834
Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli.	2008 Apr	18245232
Topical antimicrobials for burn wound infections.	2010 Jun	20429870
Development of silica-coated silver iodide nanoparticles and their biodistribution.	2012 Dec	23132228
A novel silver iodide metalo-drug: experimental and computational modelling assessment of its interaction with intracellular DNA, lipoxygenase and glutathione.	2014 Apr 22	24681027
UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications and Consent.	2016 Jan	26897901
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care.	2016 Mar-Apr	26687774
Directional growth of Ag nanorod from polymeric silver cyanide: A potential substrate for concentration dependent SERS signal enhancement leading to melamine detection.	2017 Aug 5	28472744
The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin.	2017 May 8	28484255

Patents

Sample Use Guides

In Vivo Use Guide

For up to 5 treated sites per patient, dispense 1-2 drops of solution (Aqueous Silver Diamine Fluoride, 38.3% to 43.2% w/v) into a disposable dappen dish. Transfer material directly to the tooth surface with an applicator.

Route of Administration: Dental

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 17 03:41:12 UTC 2022` Edited by `admin` on `Sat Dec 17 03:41:12 UTC 2022`
Record UNII	9ZB10YHC1C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SILVER SULFIDE

Systematic Name

English

SILVER SULFIDE [MI]

Common Name

English

Code System Code Type Description

WIKIPEDIA

SILVER SULFIDE