Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C17H19NO4 |
Molecular Weight | 301.3371 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CC[C@]23[C@H]4OC5=C(O)C=CC(C[C@@H]1[C@]2(O)CCC4=O)=C35
InChI
InChIKey=UQCNKQCJZOAFTQ-ISWURRPUSA-N
InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1
Molecular Formula | C17H19NO4 |
Molecular Weight | 301.3371 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including:
http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021611lbl.pdf | https://www.drugs.com/pro/oxymorphone.html
Curator's Comment: description was created based on several sources, including:
http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021611lbl.pdf | https://www.drugs.com/pro/oxymorphone.html
Oxymorphone is an analgesic that is FDA approved for the treatment of moderate to severe pain. It is also indicated for relief of anxiety in patients with dyspnea associated with pulmonary edema secondary to acute left ventricular dysfunction. Oxymorphone (brand names Opana, Numorphan, Numorphone) is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. Adverse reactions (≥ 2% of patients): seen with the immediate release tablet formulation Nausea, pyrexia, somnolence, vomiting, pruritus, headache, dizziness, constipation, and confusion. Concomitant use with serotonergic drugs may result in serotonin syndrome. Avoid use of mixed agonist/antagonist and partial agonist opioid analgesics with Opana because they may reduce analgesic effect of Opana or precipitate withdrawal symptoms.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
0.93 nM [Ki] | |||
80.5 nM [Ki] | |||
Target ID: CHEMBL237 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24919067 |
61.6 nM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | OPANA Approved UseEnter section text here - OPANA ER is an opioid agonist indicated for the relief of moderate to severe pain in patients requiring continuous around-the-clock opioid treatment for an extended period of time. (1) - Not intended for use as an as needed analgesic. Not indicated in the immediate post-operative period or if the pain is mild or not expected to persist for an extended period of time. (1), 1 INDICATIONS AND USAGE 1 INDICATIONS AND USAGE OPANA ER is indicated for the relief of moderate to severe pain in patients requiring continuous, around-the-clock opioid treatment for an extended period of time. Limitations of Usage OPANA ER is not intended for use as an as needed analgesic. OPANA ER is not indicated for pain in the immediate post-operative period if the pain is mild, or not expected to persist for an extended period of time. OPANA ER is only indicated for post-operative use if the patient is already receiving the drug prior to surgery or if the post-operative pain is expected to be moderate or severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines). Launch Date1959 |
|||
Palliative | OPANA Approved UseEnter section text here - OPANA ER is an opioid agonist indicated for the relief of moderate to severe pain in patients requiring continuous around-the-clock opioid treatment for an extended period of time. (1) - Not intended for use as an as needed analgesic. Not indicated in the immediate post-operative period or if the pain is mild or not expected to persist for an extended period of time. (1), 1 INDICATIONS AND USAGE 1 INDICATIONS AND USAGE OPANA ER is indicated for the relief of moderate to severe pain in patients requiring continuous, around-the-clock opioid treatment for an extended period of time. Limitations of Usage OPANA ER is not intended for use as an as needed analgesic. OPANA ER is not indicated for pain in the immediate post-operative period if the pain is mild, or not expected to persist for an extended period of time. OPANA ER is only indicated for post-operative use if the patient is already receiving the drug prior to surgery or if the post-operative pain is expected to be moderate or severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines). Launch Date1959 |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
0.27 ng/mL |
5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
1.21 ng/mL |
20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
2.59 ng/mL |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
0.7 ng/mL |
5 mg 2 times / day multiple, oral dose: 5 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
2.54 ng/mL |
20 mg 2 times / day multiple, oral dose: 20 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
4.47 ng/mL |
40 mg 2 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
4.54 ng × h/mL |
5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
17.81 ng × h/mL |
20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
37.9 ng × h/mL |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
5.6 ng × h/mL |
5 mg 2 times / day multiple, oral dose: 5 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
19.28 ng × h/mL |
20 mg 2 times / day multiple, oral dose: 20 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
36.98 ng × h/mL |
40 mg 2 times / day multiple, oral dose: 40 mg route of administration: Oral experiment type: MULTIPLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
11.3 h |
5 mg single, oral dose: 5 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
9.89 h |
20 mg single, oral dose: 20 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
|
9.35 h |
40 mg single, oral dose: 40 mg route of administration: Oral experiment type: SINGLE co-administered: |
OXYMORPHONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FED |
Doses
Dose | Population | Adverse events |
---|---|---|
20 mg 4 times / day multiple, oral Recommended Dose: 20 mg, 4 times / day Route: oral Route: multiple Dose: 20 mg, 4 times / day Sources: |
healthy, 27–44 |
Disc. AE: Vomiting, Nausea... AEs leading to discontinuation/dose reduction: Vomiting (mild, 4.3%) Sources: Nausea (4.3%) Dizziness (4.3%) |
79.4 mg 1 times / day multiple, oral Highest studied dose Dose: 79.4 mg, 1 times / day Route: oral Route: multiple Dose: 79.4 mg, 1 times / day Sources: |
unhealthy, 45.5-47.5 Health Status: unhealthy Age Group: 45.5-47.5 Sex: M+F Sources: |
Disc. AE: Abdominal pain, Chest pain... AEs leading to discontinuation/dose reduction: Abdominal pain (1.4%) Sources: Chest pain (1.4%) Serum creatine phosphokinase increased (1.4%) Serum creatine phosphokinase MB increased (1.4%) Back pain (1.4%) |
0.5 mg 5 times / day multiple, intravenous Recommended Dose: 0.5 mg, 5 times / day Route: intravenous Route: multiple Dose: 0.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Disc. AE: Opioid abuse, Respiratory depression... AEs leading to discontinuation/dose reduction: Opioid abuse Sources: Respiratory depression Addiction Hypotension (severe) |
1.5 mg 5 times / day multiple, intramuscular|subcutaneous Recommended Dose: 1.5 mg, 5 times / day Route: intramuscular|subcutaneous Route: multiple Dose: 1.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Disc. AE: Opioid abuse, Respiratory depression... AEs leading to discontinuation/dose reduction: Opioid abuse Sources: Respiratory depression Addiction Hypotension (severe) |
20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Disc. AE: Opioid abuse, Addiction... AEs leading to discontinuation/dose reduction: Opioid abuse Sources: Addiction Respiratory depression (grade 3-5) Withdrawal syndrome neonatal Anaphylaxis Hypotension (severe) Angioedema Hypersensitivity reaction Adrenal insufficiency |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Dizziness | 4.3% Disc. AE |
20 mg 4 times / day multiple, oral Recommended Dose: 20 mg, 4 times / day Route: oral Route: multiple Dose: 20 mg, 4 times / day Sources: |
healthy, 27–44 |
Nausea | 4.3% Disc. AE |
20 mg 4 times / day multiple, oral Recommended Dose: 20 mg, 4 times / day Route: oral Route: multiple Dose: 20 mg, 4 times / day Sources: |
healthy, 27–44 |
Vomiting | mild, 4.3% Disc. AE |
20 mg 4 times / day multiple, oral Recommended Dose: 20 mg, 4 times / day Route: oral Route: multiple Dose: 20 mg, 4 times / day Sources: |
healthy, 27–44 |
Abdominal pain | 1.4% Disc. AE |
79.4 mg 1 times / day multiple, oral Highest studied dose Dose: 79.4 mg, 1 times / day Route: oral Route: multiple Dose: 79.4 mg, 1 times / day Sources: |
unhealthy, 45.5-47.5 Health Status: unhealthy Age Group: 45.5-47.5 Sex: M+F Sources: |
Back pain | 1.4% Disc. AE |
79.4 mg 1 times / day multiple, oral Highest studied dose Dose: 79.4 mg, 1 times / day Route: oral Route: multiple Dose: 79.4 mg, 1 times / day Sources: |
unhealthy, 45.5-47.5 Health Status: unhealthy Age Group: 45.5-47.5 Sex: M+F Sources: |
Chest pain | 1.4% Disc. AE |
79.4 mg 1 times / day multiple, oral Highest studied dose Dose: 79.4 mg, 1 times / day Route: oral Route: multiple Dose: 79.4 mg, 1 times / day Sources: |
unhealthy, 45.5-47.5 Health Status: unhealthy Age Group: 45.5-47.5 Sex: M+F Sources: |
Serum creatine phosphokinase MB increased | 1.4% Disc. AE |
79.4 mg 1 times / day multiple, oral Highest studied dose Dose: 79.4 mg, 1 times / day Route: oral Route: multiple Dose: 79.4 mg, 1 times / day Sources: |
unhealthy, 45.5-47.5 Health Status: unhealthy Age Group: 45.5-47.5 Sex: M+F Sources: |
Serum creatine phosphokinase increased | 1.4% Disc. AE |
79.4 mg 1 times / day multiple, oral Highest studied dose Dose: 79.4 mg, 1 times / day Route: oral Route: multiple Dose: 79.4 mg, 1 times / day Sources: |
unhealthy, 45.5-47.5 Health Status: unhealthy Age Group: 45.5-47.5 Sex: M+F Sources: |
Addiction | Disc. AE | 0.5 mg 5 times / day multiple, intravenous Recommended Dose: 0.5 mg, 5 times / day Route: intravenous Route: multiple Dose: 0.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Opioid abuse | Disc. AE | 0.5 mg 5 times / day multiple, intravenous Recommended Dose: 0.5 mg, 5 times / day Route: intravenous Route: multiple Dose: 0.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Respiratory depression | Disc. AE | 0.5 mg 5 times / day multiple, intravenous Recommended Dose: 0.5 mg, 5 times / day Route: intravenous Route: multiple Dose: 0.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Hypotension | severe Disc. AE |
0.5 mg 5 times / day multiple, intravenous Recommended Dose: 0.5 mg, 5 times / day Route: intravenous Route: multiple Dose: 0.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Addiction | Disc. AE | 1.5 mg 5 times / day multiple, intramuscular|subcutaneous Recommended Dose: 1.5 mg, 5 times / day Route: intramuscular|subcutaneous Route: multiple Dose: 1.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Opioid abuse | Disc. AE | 1.5 mg 5 times / day multiple, intramuscular|subcutaneous Recommended Dose: 1.5 mg, 5 times / day Route: intramuscular|subcutaneous Route: multiple Dose: 1.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Respiratory depression | Disc. AE | 1.5 mg 5 times / day multiple, intramuscular|subcutaneous Recommended Dose: 1.5 mg, 5 times / day Route: intramuscular|subcutaneous Route: multiple Dose: 1.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Hypotension | severe Disc. AE |
1.5 mg 5 times / day multiple, intramuscular|subcutaneous Recommended Dose: 1.5 mg, 5 times / day Route: intramuscular|subcutaneous Route: multiple Dose: 1.5 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Addiction | Disc. AE | 20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Adrenal insufficiency | Disc. AE | 20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Anaphylaxis | Disc. AE | 20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Angioedema | Disc. AE | 20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Hypersensitivity reaction | Disc. AE | 20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Opioid abuse | Disc. AE | 20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Withdrawal syndrome neonatal | Disc. AE | 20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Respiratory depression | grade 3-5 Disc. AE |
20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
Hypotension | severe Disc. AE |
20 mg 5 times / day multiple, oral Recommended Dose: 20 mg, 5 times / day Route: oral Route: multiple Dose: 20 mg, 5 times / day Sources: |
unhealthy Health Status: unhealthy Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Cardiovascular and pulmonary effects of atropine reversal of oxymorphone-induced bradycardia in dogs. | 1992 Sep-Oct |
|
Effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic values, and histamine release in dogs. | 2001 Apr 1 |
|
A comparison of two opioid analgesics for relief of visceral pain induced by intestinal resection in rats. | 2001 Jan |
|
Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways. | 2001 Jul |
|
Safety and efficacy of preoperative administration of meloxicam, compared with that of ketoprofen and butorphanol in dogs undergoing abdominal surgery. | 2001 Jun |
|
Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus. | 2001 Mar 15 |
|
Double-blind, randomized comparison of the analgesic and pharmacokinetic profiles of controlled- and immediate-release oral oxycodone in cancer pain patients. | 2001 May |
|
Oxymorphone--Endo/Penwest: EN 3202, EN 3203. | 2003 |
|
Supraspinal antinociceptive effects of mu and delta agonists involve modulation of adenosine uptake. | 2003 Feb |
|
A single dose of liposome-encapsulated oxymorphone or morphine provides long-term analgesia in an animal model of neuropathic pain. | 2003 Jun |
|
Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, part I. | 2003 Mar-Apr |
|
Pharmacokinetics and dose-proportionality of oxymorphone extended release and its metabolites: results of a randomized crossover study. | 2004 Apr |
|
Cardiopulmonary effects of medetomidine, oxymorphone, or butorphanol in selegiline-treated dogs. | 2004 Apr |
|
Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. | 2004 Apr |
|
Effects of acepromazine on the incidence of vomiting associated with opioid administration in dogs. | 2004 Jan |
|
Efficacy of oxymorphone extended release in postsurgical pain: a randomized clinical trial in knee arthroplasty. | 2004 Jul |
|
Establishing the dosage equivalency of oxymorphone extended release and oxycodone controlled release in patients with cancer pain: a randomized controlled study. | 2004 Jun |
|
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. | 2004 Mar 11 |
|
Screening postmortem whole blood for oxycodone by ELISA response ratios. | 2004 May |
|
The efficacy and safety of oral immediate-release oxymorphone for postsurgical pain. | 2004 Nov |
|
Evaluation of liposome-encapsulated oxymorphone hydrochloride in mice after splenectomy. | 2004 Oct |
|
Effectiveness and safety of oral extended-release oxymorphone for the treatment of cancer pain: a pilot study. | 2005 Jan |
|
Evaluation of induction by use of a combination of oxymorphone and diazepam or hydromorphone and diazepam and maintenance of anesthesia by use of isoflurane in dogs with experimentally induced hypovolemia. | 2005 Jul |
|
GC-MS quantitation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in blood. | 2005 Jul-Aug |
|
Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways. | 2005 Mar |
|
Evaluation of the DRI oxycodone immunoassay for the detection of oxycodone in urine. | 2005 Oct |
|
Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague--Dawley rats: influence of streptozotocin-induced diabetes. | 2005 Sep |
|
Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs. | 2006 Jan |
|
Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites. | 2006 May |
|
An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites. | 2006 May |
|
Incomplete recovery of prescription opioids in urine using enzymatic hydrolysis of glucuronide metabolites. | 2006 Oct |
|
Comment: Oral oxymorphone for pain management. | 2007 Dec |
|
Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels. | 2007 Feb |
|
Efficacy and safety of OPANA ER (oxymorphone extended release) for relief of moderate to severe chronic low back pain in opioid-experienced patients: a 12-week, randomized, double-blind, placebo-controlled study. | 2007 Feb |
|
Oral oxymorphone for pain management. | 2007 Jul |
|
Oxymorphone hydrochloride, a potent opioid analgesic, is not carcinogenic in rats or mice. | 2007 Mar |
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Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat. | 2007 Mar 8 |
|
Determination of opioid analgesics in hair samples using liquid chromatography/tandem mass spectrometry and application to patients under palliative care. | 2007 Oct |
|
Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat. | 2008 Mar |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021611lbl.pdf
Subcutaneous or Intramuscular administration: Initiate treatment with 1mg to 1.5 mg, every 4 to 6 hours.
Intravenous Administration: 0.5 mg initially
Oral: 10 to 20 mg every four to six hours.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.drugs.com/pro/oxymorphone.html
Oxymorphone hydrochloride was not mutagenic when tested in the in vitro bacterial reverse mutation assay (Ames test) at concentrations of ≤5270 ug/plate, or in an in vitro mammalian cell chromosome aberration assay performed with human peripheral blood lymphocytes at concentrations ≤5000 ug/mL with or without metabolic activation.
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:23:45 GMT 2025
by
admin
on
Mon Mar 31 18:23:45 GMT 2025
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Record UNII |
9VXA968E0C
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Record Status |
Validated (UNII)
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NDF-RT |
N0000175690
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NCI_THESAURUS |
C67413
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LIVERTOX |
NBK548775
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NDF-RT |
N0000175684
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NCI_THESAURUS |
C1506
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FDA ORPHAN DRUG |
6185
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DEA NO. |
9652
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8060
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7814
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C29314
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5284604
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SUB09569MIG
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m8338
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OXYMORPHONE
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CHEMBL963
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9VXA968E0C
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admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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2034
Created by
admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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Oxymorphone
Created by
admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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100000083286
Created by
admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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937
Created by
admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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D010111
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admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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1488000
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admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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7094
Created by
admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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76-41-5
Created by
admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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SALT/SOLVATE -> PARENT |
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BINDER->LIGAND |
BINDING
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SALT/SOLVATE -> PARENT |
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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SALT/SOLVATE -> PARENT |
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Related Record | Type | Details | ||
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METABOLITE -> PARENT |
6-OH-oxymorphone has been shown in animal studies to have analgesic bioactivity
MAJOR
PLASMA; URINE
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PARENT -> METABOLITE ACTIVE | |||
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METABOLITE -> PARENT |
MAJOR
PLASMA
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METABOLITE -> PARENT |
6-OH-oxymorphone has been shown in animal studies to have analgesic bioactivity.
MAJOR
URINE
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Related Record | Type | Details | ||
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PARENT -> IMPURITY |
Related Record | Type | Details | ||
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ACTIVE MOIETY |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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Biological Half-life | PHARMACOKINETIC |
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Elimination PHARMACOKINETIC PHARMACOKINETIC |
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Volume of Distribution | PHARMACOKINETIC |
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