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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H19NO4
Molecular Weight 301.3371
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXYMORPHONE

SMILES

CN1CC[C@]23[C@H]4OC5=C(O)C=CC(C[C@@H]1[C@]2(O)CCC4=O)=C35

InChI

InChIKey=UQCNKQCJZOAFTQ-ISWURRPUSA-N
InChI=1S/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17-/m1/s1

HIDE SMILES / InChI

Molecular Formula C17H19NO4
Molecular Weight 301.3371
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 4 / 4
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021611lbl.pdf | https://www.drugs.com/pro/oxymorphone.html

Oxymorphone is an analgesic that is FDA approved for the treatment of moderate to severe pain. It is also indicated for relief of anxiety in patients with dyspnea associated with pulmonary edema secondary to acute left ventricular dysfunction. Oxymorphone (brand names Opana, Numorphan, Numorphone) is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. Adverse reactions (≥ 2% of patients): seen with the immediate release tablet formulation Nausea, pyrexia, somnolence, vomiting, pruritus, headache, dizziness, constipation, and confusion. Concomitant use with serotonergic drugs may result in serotonin syndrome. Avoid use of mixed agonist/antagonist and partial agonist opioid analgesics with Opana because they may reduce analgesic effect of Opana or precipitate withdrawal symptoms.

Originator

Sources: DOI:10.1021/ja01627a033

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
OPANA

Approved Use

Enter section text here - OPANA ER is an opioid agonist indicated for the relief of moderate to severe pain in patients requiring continuous around-the-clock opioid treatment for an extended period of time. (1) - Not intended for use as an as needed analgesic. Not indicated in the immediate post-operative period or if the pain is mild or not expected to persist for an extended period of time. (1), 1 INDICATIONS AND USAGE 1 INDICATIONS AND USAGE OPANA ER is indicated for the relief of moderate to severe pain in patients requiring continuous, around-the-clock opioid treatment for an extended period of time. Limitations of Usage OPANA ER is not intended for use as an as needed analgesic. OPANA ER is not indicated for pain in the immediate post-operative period if the pain is mild, or not expected to persist for an extended period of time. OPANA ER is only indicated for post-operative use if the patient is already receiving the drug prior to surgery or if the post-operative pain is expected to be moderate or severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines).

Launch Date

1959
Palliative
OPANA

Approved Use

Enter section text here - OPANA ER is an opioid agonist indicated for the relief of moderate to severe pain in patients requiring continuous around-the-clock opioid treatment for an extended period of time. (1) - Not intended for use as an as needed analgesic. Not indicated in the immediate post-operative period or if the pain is mild or not expected to persist for an extended period of time. (1), 1 INDICATIONS AND USAGE 1 INDICATIONS AND USAGE OPANA ER is indicated for the relief of moderate to severe pain in patients requiring continuous, around-the-clock opioid treatment for an extended period of time. Limitations of Usage OPANA ER is not intended for use as an as needed analgesic. OPANA ER is not indicated for pain in the immediate post-operative period if the pain is mild, or not expected to persist for an extended period of time. OPANA ER is only indicated for post-operative use if the patient is already receiving the drug prior to surgery or if the post-operative pain is expected to be moderate or severe and persist for an extended period of time. Physicians should individualize treatment, moving from parenteral to oral analgesics as appropriate. (See American Pain Society guidelines).

Launch Date

1959
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.27 ng/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1.21 ng/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
2.59 ng/mL
40 mg single, oral
dose: 40 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
0.7 ng/mL
5 mg 2 times / day multiple, oral
dose: 5 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
2.54 ng/mL
20 mg 2 times / day multiple, oral
dose: 20 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
4.47 ng/mL
40 mg 2 times / day multiple, oral
dose: 40 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
4.54 ng × h/mL
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
17.81 ng × h/mL
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
37.9 ng × h/mL
40 mg single, oral
dose: 40 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
5.6 ng × h/mL
5 mg 2 times / day multiple, oral
dose: 5 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
19.28 ng × h/mL
20 mg 2 times / day multiple, oral
dose: 20 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
36.98 ng × h/mL
40 mg 2 times / day multiple, oral
dose: 40 mg
route of administration: Oral
experiment type: MULTIPLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
11.3 h
5 mg single, oral
dose: 5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
9.89 h
20 mg single, oral
dose: 20 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
9.35 h
40 mg single, oral
dose: 40 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
OXYMORPHONE plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
Doses

Doses

DosePopulationAdverse events​
20 mg 4 times / day multiple, oral
Recommended
Dose: 20 mg, 4 times / day
Route: oral
Route: multiple
Dose: 20 mg, 4 times / day
Sources:
healthy, 27–44
Health Status: healthy
Age Group: 27–44
Sex: M+F
Sources:
Disc. AE: Vomiting, Nausea...
AEs leading to
discontinuation/dose reduction:
Vomiting (mild, 4.3%)
Nausea (4.3%)
Dizziness (4.3%)
Sources:
79.4 mg 1 times / day multiple, oral
Highest studied dose
Dose: 79.4 mg, 1 times / day
Route: oral
Route: multiple
Dose: 79.4 mg, 1 times / day
Sources:
unhealthy, 45.5-47.5
Health Status: unhealthy
Age Group: 45.5-47.5
Sex: M+F
Sources:
Disc. AE: Abdominal pain, Chest pain...
AEs leading to
discontinuation/dose reduction:
Abdominal pain (1.4%)
Chest pain (1.4%)
Serum creatine phosphokinase increased (1.4%)
Serum creatine phosphokinase MB increased (1.4%)
Back pain (1.4%)
Sources:
0.5 mg 5 times / day multiple, intravenous
Recommended
Dose: 0.5 mg, 5 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg, 5 times / day
Sources:
unhealthy
Disc. AE: Opioid abuse, Respiratory depression...
AEs leading to
discontinuation/dose reduction:
Opioid abuse
Respiratory depression
Addiction
Hypotension (severe)
Sources:
1.5 mg 5 times / day multiple, intramuscular|subcutaneous
Recommended
Dose: 1.5 mg, 5 times / day
Route: intramuscular|subcutaneous
Route: multiple
Dose: 1.5 mg, 5 times / day
Sources:
unhealthy
Disc. AE: Opioid abuse, Respiratory depression...
AEs leading to
discontinuation/dose reduction:
Opioid abuse
Respiratory depression
Addiction
Hypotension (severe)
Sources:
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Disc. AE: Opioid abuse, Addiction...
AEs leading to
discontinuation/dose reduction:
Opioid abuse
Addiction
Respiratory depression (grade 3-5)
Withdrawal syndrome neonatal
Anaphylaxis
Hypotension (severe)
Angioedema
Hypersensitivity reaction
Adrenal insufficiency
Sources:
AEs

AEs

AESignificanceDosePopulation
Dizziness 4.3%
Disc. AE
20 mg 4 times / day multiple, oral
Recommended
Dose: 20 mg, 4 times / day
Route: oral
Route: multiple
Dose: 20 mg, 4 times / day
Sources:
healthy, 27–44
Health Status: healthy
Age Group: 27–44
Sex: M+F
Sources:
Nausea 4.3%
Disc. AE
20 mg 4 times / day multiple, oral
Recommended
Dose: 20 mg, 4 times / day
Route: oral
Route: multiple
Dose: 20 mg, 4 times / day
Sources:
healthy, 27–44
Health Status: healthy
Age Group: 27–44
Sex: M+F
Sources:
Vomiting mild, 4.3%
Disc. AE
20 mg 4 times / day multiple, oral
Recommended
Dose: 20 mg, 4 times / day
Route: oral
Route: multiple
Dose: 20 mg, 4 times / day
Sources:
healthy, 27–44
Health Status: healthy
Age Group: 27–44
Sex: M+F
Sources:
Abdominal pain 1.4%
Disc. AE
79.4 mg 1 times / day multiple, oral
Highest studied dose
Dose: 79.4 mg, 1 times / day
Route: oral
Route: multiple
Dose: 79.4 mg, 1 times / day
Sources:
unhealthy, 45.5-47.5
Health Status: unhealthy
Age Group: 45.5-47.5
Sex: M+F
Sources:
Back pain 1.4%
Disc. AE
79.4 mg 1 times / day multiple, oral
Highest studied dose
Dose: 79.4 mg, 1 times / day
Route: oral
Route: multiple
Dose: 79.4 mg, 1 times / day
Sources:
unhealthy, 45.5-47.5
Health Status: unhealthy
Age Group: 45.5-47.5
Sex: M+F
Sources:
Chest pain 1.4%
Disc. AE
79.4 mg 1 times / day multiple, oral
Highest studied dose
Dose: 79.4 mg, 1 times / day
Route: oral
Route: multiple
Dose: 79.4 mg, 1 times / day
Sources:
unhealthy, 45.5-47.5
Health Status: unhealthy
Age Group: 45.5-47.5
Sex: M+F
Sources:
Serum creatine phosphokinase MB increased 1.4%
Disc. AE
79.4 mg 1 times / day multiple, oral
Highest studied dose
Dose: 79.4 mg, 1 times / day
Route: oral
Route: multiple
Dose: 79.4 mg, 1 times / day
Sources:
unhealthy, 45.5-47.5
Health Status: unhealthy
Age Group: 45.5-47.5
Sex: M+F
Sources:
Serum creatine phosphokinase increased 1.4%
Disc. AE
79.4 mg 1 times / day multiple, oral
Highest studied dose
Dose: 79.4 mg, 1 times / day
Route: oral
Route: multiple
Dose: 79.4 mg, 1 times / day
Sources:
unhealthy, 45.5-47.5
Health Status: unhealthy
Age Group: 45.5-47.5
Sex: M+F
Sources:
Addiction Disc. AE
0.5 mg 5 times / day multiple, intravenous
Recommended
Dose: 0.5 mg, 5 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg, 5 times / day
Sources:
unhealthy
Opioid abuse Disc. AE
0.5 mg 5 times / day multiple, intravenous
Recommended
Dose: 0.5 mg, 5 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg, 5 times / day
Sources:
unhealthy
Respiratory depression Disc. AE
0.5 mg 5 times / day multiple, intravenous
Recommended
Dose: 0.5 mg, 5 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg, 5 times / day
Sources:
unhealthy
Hypotension severe
Disc. AE
0.5 mg 5 times / day multiple, intravenous
Recommended
Dose: 0.5 mg, 5 times / day
Route: intravenous
Route: multiple
Dose: 0.5 mg, 5 times / day
Sources:
unhealthy
Addiction Disc. AE
1.5 mg 5 times / day multiple, intramuscular|subcutaneous
Recommended
Dose: 1.5 mg, 5 times / day
Route: intramuscular|subcutaneous
Route: multiple
Dose: 1.5 mg, 5 times / day
Sources:
unhealthy
Opioid abuse Disc. AE
1.5 mg 5 times / day multiple, intramuscular|subcutaneous
Recommended
Dose: 1.5 mg, 5 times / day
Route: intramuscular|subcutaneous
Route: multiple
Dose: 1.5 mg, 5 times / day
Sources:
unhealthy
Respiratory depression Disc. AE
1.5 mg 5 times / day multiple, intramuscular|subcutaneous
Recommended
Dose: 1.5 mg, 5 times / day
Route: intramuscular|subcutaneous
Route: multiple
Dose: 1.5 mg, 5 times / day
Sources:
unhealthy
Hypotension severe
Disc. AE
1.5 mg 5 times / day multiple, intramuscular|subcutaneous
Recommended
Dose: 1.5 mg, 5 times / day
Route: intramuscular|subcutaneous
Route: multiple
Dose: 1.5 mg, 5 times / day
Sources:
unhealthy
Addiction Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Adrenal insufficiency Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Anaphylaxis Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Angioedema Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Hypersensitivity reaction Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Opioid abuse Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Withdrawal syndrome neonatal Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Respiratory depression grade 3-5
Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Hypotension severe
Disc. AE
20 mg 5 times / day multiple, oral
Recommended
Dose: 20 mg, 5 times / day
Route: oral
Route: multiple
Dose: 20 mg, 5 times / day
Sources:
unhealthy
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG


OverviewOther

Other InhibitorOther SubstrateOther Inducer


Drug as perpetrator​Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
no
PubMed

PubMed

TitleDatePubMed
Cardiovascular and pulmonary effects of atropine reversal of oxymorphone-induced bradycardia in dogs.
1992 Sep-Oct
Effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic values, and histamine release in dogs.
2001 Apr 1
A comparison of two opioid analgesics for relief of visceral pain induced by intestinal resection in rats.
2001 Jan
Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways.
2001 Jul
Safety and efficacy of preoperative administration of meloxicam, compared with that of ketoprofen and butorphanol in dogs undergoing abdominal surgery.
2001 Jun
Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the "address" recognition locus.
2001 Mar 15
Double-blind, randomized comparison of the analgesic and pharmacokinetic profiles of controlled- and immediate-release oral oxycodone in cancer pain patients.
2001 May
Oxymorphone--Endo/Penwest: EN 3202, EN 3203.
2003
Supraspinal antinociceptive effects of mu and delta agonists involve modulation of adenosine uptake.
2003 Feb
A single dose of liposome-encapsulated oxymorphone or morphine provides long-term analgesia in an animal model of neuropathic pain.
2003 Jun
Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, part I.
2003 Mar-Apr
Pharmacokinetics and dose-proportionality of oxymorphone extended release and its metabolites: results of a randomized crossover study.
2004 Apr
Cardiopulmonary effects of medetomidine, oxymorphone, or butorphanol in selegiline-treated dogs.
2004 Apr
Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.
2004 Apr
Effects of acepromazine on the incidence of vomiting associated with opioid administration in dogs.
2004 Jan
Efficacy of oxymorphone extended release in postsurgical pain: a randomized clinical trial in knee arthroplasty.
2004 Jul
Establishing the dosage equivalency of oxymorphone extended release and oxycodone controlled release in patients with cancer pain: a randomized controlled study.
2004 Jun
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
2004 Mar 11
Screening postmortem whole blood for oxycodone by ELISA response ratios.
2004 May
The efficacy and safety of oral immediate-release oxymorphone for postsurgical pain.
2004 Nov
Evaluation of liposome-encapsulated oxymorphone hydrochloride in mice after splenectomy.
2004 Oct
Effectiveness and safety of oral extended-release oxymorphone for the treatment of cancer pain: a pilot study.
2005 Jan
Evaluation of induction by use of a combination of oxymorphone and diazepam or hydromorphone and diazepam and maintenance of anesthesia by use of isoflurane in dogs with experimentally induced hypovolemia.
2005 Jul
GC-MS quantitation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in blood.
2005 Jul-Aug
Oxymorphone extended release does not affect CYP2C9 or CYP3A4 metabolic pathways.
2005 Mar
Evaluation of the DRI oxycodone immunoassay for the detection of oxycodone in urine.
2005 Oct
Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague--Dawley rats: influence of streptozotocin-induced diabetes.
2005 Sep
Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs.
2006 Jan
Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites.
2006 May
An automated and fully validated LC-MS/MS procedure for the simultaneous determination of 11 opioids used in palliative care, with 5 of their metabolites.
2006 May
Incomplete recovery of prescription opioids in urine using enzymatic hydrolysis of glucuronide metabolites.
2006 Oct
Comment: Oral oxymorphone for pain management.
2007 Dec
Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels.
2007 Feb
Efficacy and safety of OPANA ER (oxymorphone extended release) for relief of moderate to severe chronic low back pain in opioid-experienced patients: a 12-week, randomized, double-blind, placebo-controlled study.
2007 Feb
Oral oxymorphone for pain management.
2007 Jul
Oxymorphone hydrochloride, a potent opioid analgesic, is not carcinogenic in rats or mice.
2007 Mar
Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat.
2007 Mar 8
Determination of opioid analgesics in hair samples using liquid chromatography/tandem mass spectrometry and application to patients under palliative care.
2007 Oct
Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat.
2008 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: http://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021611lbl.pdf
Subcutaneous or Intramuscular administration: Initiate treatment with 1mg to 1.5 mg, every 4 to 6 hours. Intravenous Administration: 0.5 mg initially Oral: 10 to 20 mg every four to six hours.
Route of Administration: Other
In Vitro Use Guide
Oxymorphone hydrochloride was not mutagenic when tested in the in vitro bacterial reverse mutation assay (Ames test) at concentrations of ≤5270 ug/plate, or in an in vitro mammalian cell chromosome aberration assay performed with human peripheral blood lymphocytes at concentrations ≤5000 ug/mL with or without metabolic activation.
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:23:45 GMT 2025
Edited
by admin
on Mon Mar 31 18:23:45 GMT 2025
Record UNII
9VXA968E0C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OXYMORPHONE
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
OXYMORPHONE CII
USP-RS  
Preferred Name English
OXYMORPHONE CII [USP-RS]
Common Name English
OXYCODONE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Common Name English
4,5.ALPHA.-EPOXY-3,14-DIHYDROXY-17-METHYLMORPHINAN-6-ONE
Systematic Name English
NIH 10323
Code English
OXYMORPHONE [VANDF]
Common Name English
OXYCODONE HYDROCHLORIDE IMPURITY, OXYMORPHONE- [USP IMPURITY]
Common Name English
DIHYDROXYMORPHINONE
Common Name English
IDS-NO-003
Code English
MORPHINAN-6-ONE, 4,5-EPOXY-3,14-DIHYDROXY-17-METHYL-
Systematic Name English
14-HYDROXYDIHYDROMORPHINONE
Common Name English
oxymorphone [INN]
Common Name English
7,8-DIHYDRO-14-HYDROXYMORPHINONE
Common Name English
Oxymorphone [WHO-DD]
Common Name English
OXYMORPHONE [MI]
Common Name English
NSC-19045
Code English
Classification Tree Code System Code
NDF-RT N0000175690
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
NCI_THESAURUS C67413
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
LIVERTOX NBK548775
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
NDF-RT N0000175684
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
NCI_THESAURUS C1506
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
FDA ORPHAN DRUG 6185
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
DEA NO. 9652
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
Code System Code Type Description
HSDB
8060
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
RXCUI
7814
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY RxNorm
NCI_THESAURUS
C29314
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
PUBCHEM
5284604
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
NSC
19045
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
EVMPD
SUB09569MIG
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
DAILYMED
9VXA968E0C
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
MERCK INDEX
m8338
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY Merck Index
WIKIPEDIA
OXYMORPHONE
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
DRUG BANK
DB01192
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-959-7
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
ChEMBL
CHEMBL963
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
EPA CompTox
DTXSID5023409
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
FDA UNII
9VXA968E0C
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
DRUG CENTRAL
2034
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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LACTMED
Oxymorphone
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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SMS_ID
100000083286
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
INN
937
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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MESH
D010111
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
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RS_ITEM_NUM
1488000
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
IUPHAR
7094
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
CAS
76-41-5
Created by admin on Mon Mar 31 18:23:45 GMT 2025 , Edited by admin on Mon Mar 31 18:23:45 GMT 2025
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
SALT/SOLVATE -> PARENT
BINDER->LIGAND
BINDING
SALT/SOLVATE -> PARENT
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
SALT/SOLVATE -> PARENT
Related Record Type Details
METABOLITE -> PARENT
6-OH-oxymorphone has been shown in animal studies to have analgesic bioactivity
MAJOR
PLASMA; URINE
PARENT -> METABOLITE ACTIVE
METABOLITE -> PARENT
MAJOR
PLASMA
METABOLITE -> PARENT
6-OH-oxymorphone has been shown in animal studies to have analgesic bioactivity.
MAJOR
URINE
Related Record Type Details
PARENT -> IMPURITY
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC Elimination
PHARMACOKINETIC
Elimination
PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC