Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H34O |
Molecular Weight | 242.4406 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCO
InChI
InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3
Molecular Formula | C16H34O |
Molecular Weight | 242.4406 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Curator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: P51648 Gene ID: 224.0 Gene Symbol: ALDH3A2 Target Organism: Homo sapiens (Human) Sources: http://www.ncbi.nlm.nih.gov/pubmed/3320042 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Palliative | EXOSURF NEONATAL Approved UseColfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome. Launch Date6.4946877E11 |
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Palliative | ALL DAY SKIN RELIEF WITH COLLOIDAL OATS Approved UseRelieves dry, itchy skin and provides hydration. |
PubMed
Title | Date | PubMed |
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Biodegradation of long-chain n-paraffins from waste oil of car engine by Acinetobacter sp. | 2001 |
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Palmitate decreases proton pumping of liver-type cytochrome c oxidase. | 2001 Dec |
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Solvent effect on ion-pair extraction of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion using alcohols and 1-octanol/octane mixed solvents. | 2001 Feb |
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[Isolation and identification of chemical constituents from Acropora pulchra]. | 2001 Sep |
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Novel use of similarity factors f2 and Sd for the development of diltiazem HCl modified-release tablets using a 3(2) factorial design. | 2002 Jan |
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Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat. | 2002 Jan |
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Efficient synthesis of phospholipids from glycidyl phosphates. | 2002 Jan 11 |
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[Coprecipitation of the Pseudomonas fluorescens lipase with hydrophobic compounds as an approach to its immobilization for catalysis in nonaqueous media]. | 2002 Jan-Feb |
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Uniform titanium dioxide (TiO(2)) microcapsules prepared by glass membrane emulsification with subsequent solvent evaporation. | 2002 Jul-Aug |
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Skin cleansing in neonates and infants--basics of cleansers. | 2002 Sep |
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Presence and physiologic regulation of alcohol oxidase activity in an indigenous fungus isolated from petroleum-contaminated soils. | 2002 Spring |
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Retardation of water evaporation by less-defective mixed monolayers spread from bulk solids onto water surface. | 2003 Apr 1 |
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Extended release lipophilic indomethacin microspheres: formulation factors and mathematical equations fitted drug release rates. | 2003 Jun |
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In situ blood-brain barrier transport of nanoparticles. | 2003 Nov |
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A new triterpenoid from Entodon okamurae Broth. | 2003 Sep |
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Influence of modified natural and synthetic surfactant preparations on bacterial killing by polymorphonuclear leucocytes. | 2004 |
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A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. | 2004 Apr 5 |
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Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach. | 2004 Feb 17 |
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Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream. | 2004 Jan |
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Natural ligands of hamster aphrodisin. | 2004 Jun |
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Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes. | 2004 Mar |
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Analysis of the labial gland secretions of the male bumble bee Bombus perplexus Cresson (Hymenoptera: Apidae) from North America. | 2004 Mar-Apr |
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Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds. | 2004 May-Jun |
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Melt solidification technique: incorporation of higher wax content in ibuprofen beads. | 2004 Oct 8 |
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A simple treatment for head lice: dry-on, suffocation-based pediculicide. | 2004 Sep |
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Paclitaxel nanoparticles for the potential treatment of brain tumors. | 2004 Sep 30 |
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Analysis of the labial gland secretions of the male bumblebee Bombus griseocollis (Hymenoptera: Apidae). | 2004 Sep-Oct |
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Cetaphil cleanser (Nuvo lotion) cures head lice. | 2005 Dec |
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Hydrophobization of glass surface by adsorption of poly(dimethylsiloxane). | 2005 Dec 6 |
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Modifying calf lung surfactant by hexadecanol. | 2005 Feb 1 |
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Nuvo lotion and the future of head-lice treatment. | 2005 May |
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A concentration-dependent multi-term linear free energy relationship for sorption of organic compounds to soils based on the hexadecane dilute-solution reference state. | 2005 Nov 15 |
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Photoallergic and allergic reaction to 2-hydroxy-4-methoxybenzophenone (sunscreen) and allergy to cetyl alcohol in cosmetic cream. | 2005 Sep |
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Detection of NAD+-dependent alcohol dehydrogenase activities in YR-1 strain of Mucor circinelloides, a potential bioremediator of petroleum contaminated soils. | 2005 Spring |
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Evaluation of otoscope cone cleaning and disinfection procedures commonly used in veterinary medical practices: a pilot study. | 2006 Apr |
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Dialkyl 3,3'-thiodipropionate and dialkyl 2,2'-thiodiacetate antioxidants by lipase-catalyzed esterification and transesterification. | 2006 Apr 19 |
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Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures. | 2006 Jun 6 |
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The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase. | 2006 Sep |
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Final report on the amended safety assessment of Propyl Gallate. | 2007 |
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Beneficial use of Cetaphil moisturizing cream as part of a daily skin care regimen for individuals with rosacea. | 2007 |
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Zeolite-catalyzed Helferich-type glycosylation of long-chain alcohols. Synthesis of acetylated alkyl 1,2-trans glycopyranosides and alkyl 1,2-cis C2-hydroxy-glycopyranosides. | 2007 Apr 9 |
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1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol. | 2007 Dec |
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Bovine serum albumin-sugar conjugates through the maillard reaction: effects on interfacial behavior and emulsifying ability. | 2008 |
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Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria. | 2008 Apr 1 |
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Adsorption and hysteresis of bisphenol A and 17alpha-ethinyl estradiol on carbon nanomaterials. | 2008 Aug 1 |
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A sugar cane native dextran as an innovative functional excipient for the development of pharmaceutical tablets. | 2008 Feb |
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Enhanced sorption of polycyclic aromatic hydrocarbons to tetra-alkyl ammonium modified smectites via cation-pi interactions. | 2008 Feb 15 |
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Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors. | 2008 Mar |
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Chemistry of the cephalic labial gland secretions of male Bombus morrisoni and B. rufocinctus, two North American bumblebee males with perching behavior. | 2008 Oct |
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Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008 Sep |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.drugs.com/mmx/exosurf-neonatal.html
Curator's Comment: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration:
Intratracheal
Substance Class |
Chemical
Created
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on
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Wed Jul 05 22:36:57 UTC 2023
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on
Wed Jul 05 22:36:57 UTC 2023
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Record UNII |
936JST6JCN
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Record Status |
Validated (UNII)
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C218
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FDA ORPHAN DRUG |
68492
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FDA ORPHAN DRUG |
14886
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JECFA EVALUATION |
1-HEXADECANOL
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CFR |
21 CFR 172.515
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EPA PESTICIDE CODE |
1508
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C005031
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M3297
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DTXSID4027991
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CETYL ALCOHOL
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936JST6JCN
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CHEMBL706
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4750
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CETYL ALCOHOL
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PRIMARY | Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O). | ||
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36653-82-4
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Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
0.1%% of chemical composition of the leaf essential oil from Moringa oleifera.
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic.
|