CETYL ALCOHOL

US Previously Marketed

First approved in 1984

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H34O
Molecular Weight	242.4406
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCCCO

InChI

InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N

InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3

HIDE SMILES / InChI

Molecular Formula	C16H34O
Molecular Weight	242.4406
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.webmd.com/drugs/2/drug-32603/cetyl-alcohol-topical/details#uses
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/cetyl-alcohol.html http://www.wikidoc.org/index.php/Cetyl_alcohol http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17

Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Fatty aldehyde dehydrogenase 1 Target ID: P51648 Gene ID: 224.0 Gene Symbol: ALDH3A2 Target Organism: Homo sapiens (Human) Sources: http://www.ncbi.nlm.nih.gov/pubmed/3320042	Substrate 656

Conditions

Condition	Modality	Targets	Highest Phase	Product
Respiratory distress syndrome, neonatal 1 Sources: https://www.drugs.com/mmx/exosurf-neonatal.html	Palliative		Approved 8360	EXOSURF NEONATAL Approved Use Colfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome. Launch Date 6.4946877E11
Dry, itchy skin 1 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31e07369-e63e-439c-e054-00144ff88e88	Palliative		Approved 8360	ALL DAY SKIN RELIEF WITH COLLOIDAL OATS Approved Use Relieves dry, itchy skin and provides hydration.

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	alcohol dehydrogenase 6

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
alcohol dehydrogenase 6	substrate 3326 Sources: https://www.futuremedicine.com/doi/abs/10.2217/nnm-2018-0419	yes

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY551407	https://www.001chemical.com/chem/36653-82-4
3B Scientific (Wuhan) Corp	3B3-033346	http://www.3bsc.com/index/pro_info.php?id=54610
AHH Chemical co.,ltd	MT-49121	http://www.ahhchemical.com/product/MT-49121.html
AK Scientific, Inc. (AKSCI)	69856	http://www.aksci.com/item_detail.php?cat=69856
AbMole Bioscience	M2355	http://www.abmole.com/products/1-hexadecanol.html
Acadechem	ACDS-071659	http://www.acadechemical.com/product/146358
Achemica	ACMC-1AJXA	http://www.achemica.com/prodinfo/?id=113849
Acros Organics	AC120480100	https://www.fishersci.com/shop/products/1-hexadecanol-96-acros-organics-3/AC120480100
Acros Organics	AC120480010	https://www.fishersci.com/shop/products/1-hexadecanol-96-acros-organics/AC120480010
Acros Organics	AC120480025	https://www.fishersci.com/shop/products/1-hexadecanol-96-acros-organics/AC120480025
Alfa Aesar	A11180	https://www.alfa.com/en/catalog/A11180/
Alfa Chemistry	ACM36653824	https://lipids.alfa-chemistry.com/product/hexadecanol-cas-36653-82-4-307386.html
Alfa Chemistry	AP36653824	https://reagents.alfa-chemistry.com/product/cetyl-alcohol-cas-36653-82-4-10687.html
Alichem	490017068	http://www.alichem.com/en/products/36653-82-4.html
Angene	AGN-PC-0WAJ6C	http://www.angenechemical.com/productshow/AGN-PC-0WAJ6C.html
Anward	ANW-28459	http://www.anward.com/pro_result/2540
ApexBio Technology	B1651	http://www.apexbt.com/1-hexadecanol.html
Aronis	ARONIS25150	http://www.aronis.ru/store/index.php?main_page=product_info&cPath=1&products_id=18046
Aurora Fine Chemicals LLC	K02.101.449	http://online.aurorafinechemicals.com/info?ID=K02.101.449
Aurum Pharmatech LLC	NE10353	http://www.Aurumpharmatech.com/Product/ProductDetails/NE10353
Avantor Inc	BJ03884-500G	https://us.vwr.com/store/product/25947408/1-hexadecanol-cetyl-alcohol-tested-according-to-ph-eur-riedel-de-haentm
Avantor Inc	200008-680	https://us.vwr.com/store/product/7514430/1-hexadecanol-cetyl-alcohol-96
Avantor Inc	470300-686	https://us.vwr.com/store/product/8869497/cetyl-alcohol
BLD Pharm	BD58705	http://www.bldpharm.com/products/36653-82-4.html
BOC Sciences	284474-73-3	https://www.bocsci.com/1-hexadecan-d33-ol-cas-284474-73-3-item-79338.html
BOC Sciences	203633-15-2	https://www.bocsci.com/n-hexadecanol-2-2-3-3-16-16-16-d31-cas-203633-15-2-item-79122.html
BOC Sciences	75736-52-6	https://www.bocsci.com/n-hexadecyl-16-16-16-d3-alcohol-cas-75736-52-6-item-79243.html
BioCrick	BCC4616	http://www.biocrick.com/1-Hexadecanol-BCC4616.html
CSNpharm	CSN25536	https://www.csnpharm.com/products/1-hexadecanol.html
Chem Scene	CS-D1348	http://www.chemscene.com/36653-82-4.html
ChemMol	99075020	http://www.chemmol.com/chemmol/99075020.html
ChemMol	99099734	http://www.chemmol.com/chemmol/99099734.html
Chemspace	CSSB00000610633	https://chem-space.com/CSSB00000610633
Clearsynth	CS-EG-00309	https://www.clearsynth.com/en/CSEG00309.html
Clearsynth	CS-ER-02595	https://www.clearsynth.com/en/CSER02595.html
Finetech	FT-0701357	http://www.finetechnology-ind.com/prod/detail/pub/36653-82-4.html
Finetech	FT-0707360	http://www.finetechnology-ind.com/prod/detail/pub/36653-82-4.html
Hairui	HR125172	http://www.hairuichem.com/en/product/36653-82-4.html
LGC Standards	DRE-C14192500	https://www.lgcstandards.com/US/en/p/DRE-C14192500
Lab Network	LN00195823	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00195823
Matrix Scientific	94644	https://www.matrixscientific.com/094644.html
MedChem Express	HY-B1465	https://www.medchemexpress.com/1-hexadecanol.html
Molcore	MC551407	https://www.molcore.com/product/36653-82-4
Oakwood	225485	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=106484&ExtHyperLink=1
Parchem	1665	http://www.parchem.com/chemical-supplier-distributor/Cetyl-Alcohol-003052.aspx
Parchem	8280	http://www.parchem.com/chemical-supplier-distributor/hexadecanol-010192.aspx
Parchem	56707	https://www.parchem.com/chemical-supplier-distributor/Cetyl-Alcohol-056707.aspx
Sigma-Aldrich	258741_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/258741?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	05-2510_SAJ	https://www.sigmaaldrich.com/catalog/product/saj/052510?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	52238_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/52238?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	52240_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/52240?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	1103003_USP	https://www.sigmaaldrich.com/catalog/product/usp/1103003?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S056002	http://www.sinfoobiotech.com/product/1059400
Smolecule	S562403	https://www.smolecule.com/products/s562403
TCI (Tokyo Chemical Industry)	H0071	http://www.tcichemicals.com/eshop/en/us/commodity/H0071/index.html
THE BioTek	bt-308538	https://www.thebiotek.com/product/others/bt-308538
VladaChem	VL162191	https://www.vladachem.com/product.php?products=36653-82-4
abcr GmbH	AB117000	http://www.abcr.com/shop/en/AB117000
eNovation Chemicals	D409374	http://www.enovationchem.com/productDetails.asp?productID=D409374
iChemical	EBD2204285	http://www.ichemical.com/products/36653-82-4.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-9457426256	https://mcule.com/MCULE-9457426256/

PubMed

Title	Date	PubMed
Biodegradation of long-chain n-paraffins from waste oil of car engine by Acinetobacter sp.	2001	16232955
Palmitate decreases proton pumping of liver-type cytochrome c oxidase.	2001 Dec	11737187
Solvent effect on ion-pair extraction of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion using alcohols and 1-octanol/octane mixed solvents.	2001 Feb	11990543
[Isolation and identification of chemical constituents from Acropora pulchra].	2001 Sep	11799771
Novel use of similarity factors f2 and Sd for the development of diltiazem HCl modified-release tablets using a 3(2) factorial design.	2002 Jan	11858527
Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat.	2002 Jan	11792723
Efficient synthesis of phospholipids from glycidyl phosphates.	2002 Jan 11	11777459
[Coprecipitation of the Pseudomonas fluorescens lipase with hydrophobic compounds as an approach to its immobilization for catalysis in nonaqueous media].	2002 Jan-Feb	11875972
Uniform titanium dioxide (TiO(2)) microcapsules prepared by glass membrane emulsification with subsequent solvent evaporation.	2002 Jul-Aug	12396381
Skin cleansing in neonates and infants--basics of cleansers.	2002 Sep	12420908
Presence and physiologic regulation of alcohol oxidase activity in an indigenous fungus isolated from petroleum-contaminated soils.	2002 Spring	12018252
Retardation of water evaporation by less-defective mixed monolayers spread from bulk solids onto water surface.	2003 Apr 1	12742043
Extended release lipophilic indomethacin microspheres: formulation factors and mathematical equations fitted drug release rates.	2003 Jun	12791411
In situ blood-brain barrier transport of nanoparticles.	2003 Nov	14661921
A new triterpenoid from Entodon okamurae Broth.	2003 Sep	12931851
Influence of modified natural and synthetic surfactant preparations on bacterial killing by polymorphonuclear leucocytes.	2004	15638129
A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates.	2004 Apr 5	15760087
Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach.	2004 Feb 17	15803738
Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream.	2004 Jan	15059111
Natural ligands of hamster aphrodisin.	2004 Jun	15201209
Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes.	2004 Mar	14988513
Analysis of the labial gland secretions of the male bumble bee Bombus perplexus Cresson (Hymenoptera: Apidae) from North America.	2004 Mar-Apr	15241938
Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds.	2004 May-Jun	15154773
Melt solidification technique: incorporation of higher wax content in ibuprofen beads.	2004 Oct 8	15760058
A simple treatment for head lice: dry-on, suffocation-based pediculicide.	2004 Sep	15342886
Paclitaxel nanoparticles for the potential treatment of brain tumors.	2004 Sep 30	15380635
Analysis of the labial gland secretions of the male bumblebee Bombus griseocollis (Hymenoptera: Apidae).	2004 Sep-Oct	15540604
Cetaphil cleanser (Nuvo lotion) cures head lice.	2005 Dec	16322200
Hydrophobization of glass surface by adsorption of poly(dimethylsiloxane).	2005 Dec 6	16316107
Modifying calf lung surfactant by hexadecanol.	2005 Feb 1	15667185
Nuvo lotion and the future of head-lice treatment.	2005 May	15867085
A concentration-dependent multi-term linear free energy relationship for sorption of organic compounds to soils based on the hexadecane dilute-solution reference state.	2005 Nov 15	16323782
Photoallergic and allergic reaction to 2-hydroxy-4-methoxybenzophenone (sunscreen) and allergy to cetyl alcohol in cosmetic cream.	2005 Sep	16128759
Detection of NAD+-dependent alcohol dehydrogenase activities in YR-1 strain of Mucor circinelloides, a potential bioremediator of petroleum contaminated soils.	2005 Spring	15917606
Evaluation of otoscope cone cleaning and disinfection procedures commonly used in veterinary medical practices: a pilot study.	2006 Apr	16515658
Dialkyl 3,3'-thiodipropionate and dialkyl 2,2'-thiodiacetate antioxidants by lipase-catalyzed esterification and transesterification.	2006 Apr 19	16608215
Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures.	2006 Jun 6	16732659
The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase.	2006 Sep	16954110
Final report on the amended safety assessment of Propyl Gallate.	2007	18080874
Beneficial use of Cetaphil moisturizing cream as part of a daily skin care regimen for individuals with rosacea.	2007	17538804
Zeolite-catalyzed Helferich-type glycosylation of long-chain alcohols. Synthesis of acetylated alkyl 1,2-trans glycopyranosides and alkyl 1,2-cis C2-hydroxy-glycopyranosides.	2007 Apr 9	17217935
1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.	2007 Dec	18045091
Bovine serum albumin-sugar conjugates through the maillard reaction: effects on interfacial behavior and emulsifying ability.	2008	18781054
Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria.	2008 Apr 1	18093811
Adsorption and hysteresis of bisphenol A and 17alpha-ethinyl estradiol on carbon nanomaterials.	2008 Aug 1	18754464
A sugar cane native dextran as an innovative functional excipient for the development of pharmaceutical tablets.	2008 Feb	17540546
Enhanced sorption of polycyclic aromatic hydrocarbons to tetra-alkyl ammonium modified smectites via cation-pi interactions.	2008 Feb 15	18351080
Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors.	2008 Mar	18468122
Chemistry of the cephalic labial gland secretions of male Bombus morrisoni and B. rufocinctus, two North American bumblebee males with perching behavior.	2008 Oct	18758863
Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat.	2008 Sep	18515819

Patents

Sample Use Guides

In Vivo Use Guide

5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.

Route of Administration: Intratracheal

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:36:57 UTC 2023` Edited by `admin` on `Wed Jul 05 22:36:57 UTC 2023`
Record UNII	936JST6JCN
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CETYL ALCOHOL

Official Name

English

CETYL ALCOHOL [MART.]

Common Name

English

FEMA NO. 2554

Code

English

CETYL ALCOHOL [USP-RS]

Common Name

English

CETYL ALCOHOL [MI]

Common Name

English

N-1-HEXADECANOL

Common Name

English

HEXADECANOL

Systematic Name

English

CETYL ALCHOL

Common Name

English

CETYL ALCOHOL [EP MONOGRAPH]

Common Name

English

PALMITIC ALCOHOL

Common Name

English

CETYL ALCOHOL [VANDF]

Common Name

English

NSC-4194

Code

English

HEXADECYL ALCOHOL

Systematic Name

English

ALCOHOL CETYLICUS [WHO-IP LATIN]

Common Name

English

CETYL ALCOHOL [WHO-IP]

Common Name

English

Cetyl alcohol [WHO-DD]

Common Name

English

PALMITYL ALCOHOL

Systematic Name

English

CETANOL

Systematic Name

English

CETYL ALCOHOL [INCI]

Common Name

English

1-HEXADECANOL [FHFI]

Common Name

English

CETYL ALCOHOL [II]

Common Name

English

N-HEXADECANOL

Common Name

English

CETYL ALCOHOL [HSDB]

Common Name

English

CETANOL [JAN]

Common Name

English

1-Hexadecanol

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C218