Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H34O |
| Molecular Weight | 242.4406 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCO
InChI
InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3
| Molecular Formula | C16H34O |
| Molecular Weight | 242.4406 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Curator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P51648 Gene ID: 224.0 Gene Symbol: ALDH3A2 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | EXOSURF NEONATAL Approved UseColfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome. Launch Date6.4946877E11 |
|||
| Palliative | ALL DAY SKIN RELIEF WITH COLLOIDAL OATS Approved UseRelieves dry, itchy skin and provides hydration. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Biodegradation of long-chain n-paraffins from waste oil of car engine by Acinetobacter sp. | 2001 |
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| Solvent effect on ion-pair extraction of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion using alcohols and 1-octanol/octane mixed solvents. | 2001 Feb |
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| Synthesis of fatty acid esters by recombinant Staphylococcus epidermidis lipases in aqueous environment. | 2001 May |
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| Novel use of similarity factors f2 and Sd for the development of diltiazem HCl modified-release tablets using a 3(2) factorial design. | 2002 Jan |
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| Uniform titanium dioxide (TiO(2)) microcapsules prepared by glass membrane emulsification with subsequent solvent evaporation. | 2002 Jul-Aug |
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| Relationship between internal phase volume and emulsion stability: the cetyl alcohol/stearyl alcohol system. | 2003 Aug |
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| Concomitant allergic reaction to cetyl alcohol and crotamiton. | 2003 Nov |
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| In situ blood-brain barrier transport of nanoparticles. | 2003 Nov |
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| A new triterpenoid from Entodon okamurae Broth. | 2003 Sep |
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| Influence of modified natural and synthetic surfactant preparations on bacterial killing by polymorphonuclear leucocytes. | 2004 |
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| A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates. | 2004 Apr 5 |
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| Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach. | 2004 Feb 17 |
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| Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream. | 2004 Jan |
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| Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes. | 2004 Mar |
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| Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds. | 2004 May-Jun |
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| Melt solidification technique: incorporation of higher wax content in ibuprofen beads. | 2004 Oct 8 |
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| Width of the hexadecane-water interface: a discrepancy resolved. | 2005 Dec 6 |
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| Modifying calf lung surfactant by hexadecanol. | 2005 Feb 1 |
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| Nuvo lotion and the future of head-lice treatment. | 2005 May |
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| Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules. | 2005 Sep 15 |
|
| Silicon nanoparticles: applications in cell biology and medicine. | 2006 |
|
| The effect of Cetaphil Gentle Skin Cleanser on the skin barrier of patients with rosacea. | 2006 Apr |
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| Selection of surfactants for stable paraffin-in-water dispersions, undergoing solid-liquid transition of the dispersed particles. | 2006 Apr 11 |
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| Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. | 2006 Aug |
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| Computer studies on the effects of long chain alcohols on sodium dodecyl sulfate (SDS) molecules in SDS/dodecanol and SDS/hexadecanol monolayers at the air/water interface. | 2006 Jul 6 |
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| Development and optimization of a novel sustained-release dextran tablet formulation for propranolol hydrochloride. | 2006 Jul 6 |
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| Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures. | 2006 Jun 6 |
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| Comedogenicity in rabbit: some cosmetic ingredients/vehicles. | 2007 |
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| 1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol. | 2007 Dec |
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| Bovine serum albumin-sugar conjugates through the maillard reaction: effects on interfacial behavior and emulsifying ability. | 2008 |
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| Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria. | 2008 Apr 1 |
|
| Adsorption and hysteresis of bisphenol A and 17alpha-ethinyl estradiol on carbon nanomaterials. | 2008 Aug 1 |
|
| Preparation and characterization of herbal creams for improvement of skin viscoelastic properties. | 2008 Jun |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration:
Intratracheal
| Substance Class |
Chemical
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| Record UNII |
936JST6JCN
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C218
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FDA ORPHAN DRUG |
68492
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FDA ORPHAN DRUG |
14886
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JECFA EVALUATION |
1-HEXADECANOL
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CFR |
21 CFR 172.515
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EPA PESTICIDE CODE |
1508
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16125
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DB09494
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C47442
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1103003
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C005031
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M3297
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DTXSID4027991
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CETYL ALCOHOL
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936JST6JCN
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CHEMBL706
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4750
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CETYL ALCOHOL
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PRIMARY | Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O). | ||
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36653-82-4
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936JST6JCN
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> CONSTITUENT ALWAYS PRESENT |
0.1%% of chemical composition of the leaf essential oil from Moringa oleifera.
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic.
|
