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Details

Stereochemistry ACHIRAL
Molecular Formula C16H34O
Molecular Weight 242.4406
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CETYL ALCOHOL

SMILES

CCCCCCCCCCCCCCCCO

InChI

InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3

HIDE SMILES / InChI

Molecular Formula C16H34O
Molecular Weight 242.4406
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including: https://www.drugs.com/dict/cetyl-alcohol.html http://www.wikidoc.org/index.php/Cetyl_alcohol http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17

Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.

Originator

Sources: DOI: 10.1111/j.1478-4408.1890.tb02251.x

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P51648
Gene ID: 224.0
Gene Symbol: ALDH3A2
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
EXOSURF NEONATAL

Approved Use

Colfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome.

Launch Date

6.4946877E11
Palliative
ALL DAY SKIN RELIEF WITH COLLOIDAL OATS

Approved Use

Relieves dry, itchy skin and provides hydration.
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

OverviewOther

Other InhibitorOther SubstrateOther Inducer

Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Biodegradation of long-chain n-paraffins from waste oil of car engine by Acinetobacter sp.
2001
Solvent effect on ion-pair extraction of 2-(2-pyridylazo)-1-naphthol-4-sulfonate anion with solvated hydroxonium ion using alcohols and 1-octanol/octane mixed solvents.
2001 Feb
Synthesis of fatty acid esters by recombinant Staphylococcus epidermidis lipases in aqueous environment.
2001 May
Novel use of similarity factors f2 and Sd for the development of diltiazem HCl modified-release tablets using a 3(2) factorial design.
2002 Jan
Uniform titanium dioxide (TiO(2)) microcapsules prepared by glass membrane emulsification with subsequent solvent evaporation.
2002 Jul-Aug
Relationship between internal phase volume and emulsion stability: the cetyl alcohol/stearyl alcohol system.
2003 Aug
Concomitant allergic reaction to cetyl alcohol and crotamiton.
2003 Nov
In situ blood-brain barrier transport of nanoparticles.
2003 Nov
A new triterpenoid from Entodon okamurae Broth.
2003 Sep
Influence of modified natural and synthetic surfactant preparations on bacterial killing by polymorphonuclear leucocytes.
2004
A novel approach in the assessment of polymeric film formation and film adhesion on different pharmaceutical solid substrates.
2004 Apr 5
Covalent attachment of phospholipid analogous polymers to modify a polymeric membrane surface: a novel approach.
2004 Feb 17
Contact dermatitis due to lanoconazole, cetyl alcohol and diethyl sebacate in lanoconazole cream.
2004 Jan
Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes.
2004 Mar
Theoretical scales of hydrogen bond acidity and basicity for application in QSAR/QSPR studies and drug design. Partitioning of aliphatic compounds.
2004 May-Jun
Melt solidification technique: incorporation of higher wax content in ibuprofen beads.
2004 Oct 8
Width of the hexadecane-water interface: a discrepancy resolved.
2005 Dec 6
Modifying calf lung surfactant by hexadecanol.
2005 Feb 1
Nuvo lotion and the future of head-lice treatment.
2005 May
Displacement of sterols from sterol/sphingomyelin domains in fluid bilayer membranes by competing molecules.
2005 Sep 15
Silicon nanoparticles: applications in cell biology and medicine.
2006
The effect of Cetaphil Gentle Skin Cleanser on the skin barrier of patients with rosacea.
2006 Apr
Selection of surfactants for stable paraffin-in-water dispersions, undergoing solid-liquid transition of the dispersed particles.
2006 Apr 11
Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia.
2006 Aug
Computer studies on the effects of long chain alcohols on sodium dodecyl sulfate (SDS) molecules in SDS/dodecanol and SDS/hexadecanol monolayers at the air/water interface.
2006 Jul 6
Development and optimization of a novel sustained-release dextran tablet formulation for propranolol hydrochloride.
2006 Jul 6
Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures.
2006 Jun 6
Comedogenicity in rabbit: some cosmetic ingredients/vehicles.
2007
1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol.
2007 Dec
Bovine serum albumin-sugar conjugates through the maillard reaction: effects on interfacial behavior and emulsifying ability.
2008
Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria.
2008 Apr 1
Adsorption and hysteresis of bisphenol A and 17alpha-ethinyl estradiol on carbon nanomaterials.
2008 Aug 1
Preparation and characterization of herbal creams for improvement of skin viscoelastic properties.
2008 Jun
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration: Intratracheal
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 16 16:06:58 UTC 2022
Edited
by admin
on Fri Dec 16 16:06:58 UTC 2022
Record UNII
936JST6JCN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CETYL ALCOHOL
EP   HSDB   II   INCI   MART.   MI   USP-RS   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
CETYL ALCOHOL [MART.]
Common Name English
FEMA NO. 2554
Code English
CETYL ALCOHOL [USP-RS]
Common Name English
CETYL ALCOHOL [MI]
Common Name English
N-1-HEXADECANOL
Common Name English
HEXADECANOL
Systematic Name English
CETYL ALCHOL
Common Name English
CETYL ALCOHOL [EP MONOGRAPH]
Common Name English
PALMITIC ALCOHOL
Common Name English
CETYL ALCOHOL [VANDF]
Common Name English
NSC-4194
Code English
HEXADECYL ALCOHOL
Systematic Name English
ALCOHOL CETYLICUS [WHO-IP LATIN]
Common Name English
CETYL ALCOHOL [WHO-IP]
Common Name English
Cetyl alcohol [WHO-DD]
Common Name English
PALMITYL ALCOHOL
Systematic Name English
CETANOL
JAN  
Systematic Name English
CETYL ALCOHOL [INCI]
Common Name English
1-HEXADECANOL [FHFI]
Common Name English
CETYL ALCOHOL [II]
Common Name English
N-HEXADECANOL
Common Name English
CETYL ALCOHOL [HSDB]
Common Name English
CETANOL [JAN]
Common Name English
1-Hexadecanol
FHFI  
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C218
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
FDA ORPHAN DRUG 68492
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
FDA ORPHAN DRUG 14886
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
JECFA EVALUATION 1-HEXADECANOL
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
CFR 21 CFR 172.515
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EPA PESTICIDE CODE 1508
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
Code System Code Type Description
CHEBI
16125
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
DRUG BANK
DB09494
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
NCI_THESAURUS
C47442
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
RS_ITEM_NUM
1103003
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PRIMARY
EVMPD
SUB12479MIG
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PRIMARY
CAS
124-29-8
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
ALTERNATIVE
MESH
C005031
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PRIMARY
NSC
4194
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PRIMARY
PUBCHEM
2682
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PRIMARY
ECHA (EC/EINECS)
253-149-0
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PRIMARY
HSDB
2643
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PRIMARY
RXCUI
20615
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY RxNorm
MERCK INDEX
M3297
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY Merck Index
EPA CompTox
DTXSID4027991
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
WIKIPEDIA
CETYL ALCOHOL
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
FDA UNII
936JST6JCN
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
ChEMBL
CHEMBL706
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
DRUG CENTRAL
4750
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
CETYL ALCOHOL
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O).
CAS
36653-82-4
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
DAILYMED
936JST6JCN
Created by admin on Fri Dec 16 16:06:58 UTC 2022 , Edited by admin on Fri Dec 16 16:06:58 UTC 2022
PRIMARY
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Related Record Type Details
ACTIVE MOIETY
Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic.