Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H34O |
| Molecular Weight | 242.4406 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCO
InChI
InChIKey=BXWNKGSJHAJOGX-UHFFFAOYSA-N
InChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3
| Molecular Formula | C16H34O |
| Molecular Weight | 242.4406 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Curator's Comment: description was created based on several sources, including:
https://www.drugs.com/dict/cetyl-alcohol.html
http://www.wikidoc.org/index.php/Cetyl_alcohol
http://wisderm.com/ingredients/Cetyl+Alcohol#ref-17
Cetyl alcohol is the 16-carbon alcohol corresponding to palmitic acid, so called because it is isolated from among the hydrolysis products of spermaceti. This medication is used as a moisturizer to treat or prevent dry, rough, scaly, itchy skin and minor skin irritations (e.g., diaper rash, skin burns from radiation therapy). Most emollients can be used safely and effectively with no side effects. However, burning, stinging, redness, or irritation may occur. A very serious allergic reaction to this drug is rare.
Originator
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P51648 Gene ID: 224.0 Gene Symbol: ALDH3A2 Target Organism: Homo sapiens (Human) |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | EXOSURF NEONATAL Approved UseColfosceril, cetyl alcohol, and tyloxapol combination is indicated for the prophylactic treatment of infants with birth weights of less than 1350 grams who are at risk of developing respiratory distress syndrome. Launch Date1990 |
|||
| Palliative | ALL DAY SKIN RELIEF WITH COLLOIDAL OATS Approved UseRelieves dry, itchy skin and provides hydration. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hydrophobic bacteria at the hexadecane-water interface: examination of micrometre-scale interfacial properties. | 2008-11-15 |
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| Dual role of preputial gland secretion and its major components in sex recognition of mice. | 2008-10-20 |
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| Chemistry of the cephalic labial gland secretions of male Bombus morrisoni and B. rufocinctus, two North American bumblebee males with perching behavior. | 2008-10 |
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| Sex- and gonad-affecting scent compounds and 3 male pheromones in the rat. | 2008-09 |
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| Adsorption and hysteresis of bisphenol A and 17alpha-ethinyl estradiol on carbon nanomaterials. | 2008-08-01 |
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| The male sex pheromone of the butterfly Bicyclus anynana: towards an evolutionary analysis. | 2008-07-23 |
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| Comparison of two diluents of 1% methoxsalen in the treatment of vitiligo. | 2008-07-04 |
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| Molecular modeling of surfactant covered oil-water interfaces: Dynamics, microstructure, and barrier for mass transport. | 2008-06-21 |
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| Preparation and characterization of herbal creams for improvement of skin viscoelastic properties. | 2008-06 |
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| Mechanical properties of hexadecane-water interfaces with adsorbed hydrophobic bacteria. | 2008-04-01 |
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| Novel molecular precursor of lanthanide complexes with long chain mono cis-butene dicarboxylate to the controlled synthesis of Y2O3:Eu3+ phosphors. | 2008-03 |
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| Precursor system of liquid crystalline phase containing propolis microparticles for the treatment of periodontal disease: development and characterization. | 2008-03 |
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| Enhanced sorption of polycyclic aromatic hydrocarbons to tetra-alkyl ammonium modified smectites via cation-pi interactions. | 2008-02-15 |
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| Social bacteria and asocial eukaryotes. | 2008-02 |
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| A sugar cane native dextran as an innovative functional excipient for the development of pharmaceutical tablets. | 2008-02 |
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| Substrate specificity of a long-chain alkylamine-degrading Pseudomonas sp isolated from activated sludge. | 2008-02 |
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| Does the solid-liquid crystal phase transition provoke the spin-state change in spin-crossover metallomesogens? | 2008-01-30 |
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| Potential of hexadecane-utilizing soil-microorganisms for growth on hexadecanol, hexadecanal and hexadecanoic acid as sole sources of carbon and energy. | 2008-01 |
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| Bovine serum albumin-sugar conjugates through the maillard reaction: effects on interfacial behavior and emulsifying ability. | 2008 |
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| Formulation of sustained-release verapamil HCl and diltiazem HCl semisolid matrix capsules. | 2008 |
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| 1H NMR investigations of inclusion complexes between beta-cyclodextrin and 1-hexadecanol. | 2007-12 |
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| Cholesterol displacement from membrane phospholipids by hexadecanol. | 2007-09-15 |
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| Zeolite-catalyzed Helferich-type glycosylation of long-chain alcohols. Synthesis of acetylated alkyl 1,2-trans glycopyranosides and alkyl 1,2-cis C2-hydroxy-glycopyranosides. | 2007-04-09 |
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| Putative chemical signals about sex, individuality, and genetic background in the preputial gland and urine of the house mouse (Mus musculus). | 2007-03 |
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| Modifying dipalmitoylphosphatidylcholine monolayers by n-hexadecanol and dipalmitoylglycerol. | 2007-02 |
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| Final report on the amended safety assessment of Propyl Gallate. | 2007 |
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| Comedogenicity in rabbit: some cosmetic ingredients/vehicles. | 2007 |
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| Beneficial use of Cetaphil moisturizing cream as part of a daily skin care regimen for individuals with rosacea. | 2007 |
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| Effects of dioctadecyl dimethyl ammonium chloride on the rheological behavior of behenyl trimethyl ammonium chloride/1-hexadecanol/water ternary system. | 2006-10-01 |
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| Structure and organization of hexadecanol isomers adsorbed to the air/water interface. | 2006-09-12 |
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| The metabolism of fatty alcohols in lipid nanoparticles by alcohol dehydrogenase. | 2006-09 |
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| Causal agents of photoallergic contact dermatitis diagnosed in the national institute of dermatology of Colombia. | 2006-08 |
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| Cytosolic triacylglycerol biosynthetic pathway in oilseeds. Molecular cloning and expression of peanut cytosolic diacylglycerol acyltransferase. | 2006-08 |
|
| Computer studies on the effects of long chain alcohols on sodium dodecyl sulfate (SDS) molecules in SDS/dodecanol and SDS/hexadecanol monolayers at the air/water interface. | 2006-07-06 |
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| Development and optimization of a novel sustained-release dextran tablet formulation for propranolol hydrochloride. | 2006-07-06 |
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| Interfacial rheology and structure of straight-chain and branched fatty alcohol mixtures. | 2006-06-06 |
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| Effects of pressure sensitive adhesives and chemical permeation enhancers on the permeability of fentanyl through excised rat skin. | 2006-06 |
|
| Development of a respirable, sustained release microcarrier for 5-fluorouracil II: In vitro and in vivo optimization of lipid coated nanoparticles. | 2006-05 |
|
| Dialkyl 3,3'-thiodipropionate and dialkyl 2,2'-thiodiacetate antioxidants by lipase-catalyzed esterification and transesterification. | 2006-04-19 |
|
| Selection of surfactants for stable paraffin-in-water dispersions, undergoing solid-liquid transition of the dispersed particles. | 2006-04-11 |
|
| The effect of Cetaphil Gentle Skin Cleanser on the skin barrier of patients with rosacea. | 2006-04 |
|
| Evaluation of otoscope cone cleaning and disinfection procedures commonly used in veterinary medical practices: a pilot study. | 2006-04 |
|
| Utility of 1-octanol/octane mixed solvents for the solvent extraction of aluminum(III), gallium(III), and indium(III) with 8-quinolinol. | 2006-03 |
|
| CCN activation of pure and coated carbon black particles. | 2006-02-15 |
|
| "Special" formula for head lice treatment--not so special, after all. | 2006-02 |
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| Silicon nanoparticles: applications in cell biology and medicine. | 2006 |
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| Cetaphil cleanser (Nuvo lotion) cures head lice. | 2005-12 |
|
| A concentration-dependent multi-term linear free energy relationship for sorption of organic compounds to soils based on the hexadecane dilute-solution reference state. | 2005-11-15 |
|
| Structure and rheology of semisolid o/w creams containing cetyl alcohol/non-ionic surfactant mixed emulsifier and different polymers. | 2004-04 |
|
| Evaluation of hydrophobic materials as matrices for controlled-release drug delivery. | 2003-07 |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Suspension: 13.5 mg of colfosceril palmitate, 1.5 mg of cetyl alcohol, and 1 mg of tyloxapol per mL, when reconstituted with 8 mL of Sterile Water for Injection supplied by manufacturer
5 mL of reconstituted suspension per kg of body weight administered (in two half-doses) as soon as possible after diagnosis of respiratory distress syndrome (RDS) is confirmed; a second dose (given in two half-doses) should be administered approximately twelve hours after the first dose, provided that the infant remains on mechanical ventilation.
Route of Administration:
Intratracheal
| Substance Class |
Chemical
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| Record UNII |
936JST6JCN
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| Record Status |
Validated (UNII)
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C218
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FDA ORPHAN DRUG |
68492
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FDA ORPHAN DRUG |
14886
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JECFA EVALUATION |
1-HEXADECANOL
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CFR |
21 CFR 172.515
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EPA PESTICIDE CODE |
1508
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16125
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DB09494
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100000078547
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C47442
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1103003
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C005031
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4194
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2682
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253-149-0
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2643
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m3297
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DTXSID4027991
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CETYL ALCOHOL
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936JST6JCN
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CHEMBL706
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4750
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CETYL ALCOHOL
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PRIMARY | Description: Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS and ether R. Category: Emulsifying agent; viscosity-increasing agent. Storage: Cetyl alcohol should be kept in a well-closed container. Definition: Cetyl alcohol is a mixture of solid alcohols consisting mainly of 1-hexadecanol (C16H34O). | ||
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36653-82-4
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936JST6JCN
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> CONSTITUENT ALWAYS PRESENT |
0.1%% of chemical composition of the leaf essential oil from Moringa oleifera.
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
Unctuous, colourless flakes or a white, crystalline mass; odour, faint and characteristic.
|
