UFENAMATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H18F3NO2
Molecular Weight	337.3362
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCOC(=O)C1=C(NC2=CC=CC(=C2)C(F)(F)F)C=CC=C1

InChI

InChIKey=JDLSRXWHEBFHNC-UHFFFAOYSA-N

InChI=1S/C18H18F3NO2/c1-2-3-11-24-17(23)15-9-4-5-10-16(15)22-14-8-6-7-13(12-14)18(19,20)21/h4-10,12,22H,2-3,11H2,1H3

HIDE SMILES / InChI

Molecular Formula	C18H18F3NO2
Molecular Weight	337.3362
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.rad-ar.or.jp/siori/english/kekka_plain.cgi?n=2254
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/26424024 and https://www.researchgate.net/publication/285959437_Evaluation_of_efficacy_and_safety_of_5_butyl_flufenamate_ointment_in_treating_scrotal_eczema

Ufenamate is a topical analgesic. It is indicated for pain and inflammation associated with musculoskeletal and joint disorders. It is a COX inhibitor. Ufenamate is freely soluble in oil and is poorly soluble in water. It is used in the form of ointments or creams. It is manufactured under the brand name Combec in Japan. It is also an ingredient of Fenazol Ointment 5%, used in Japan for the treatment of eczema, dermatitis and herpes zoster.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cyclooxygenase-1 127 Target ID: CHEMBL221 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01823	Inhibitor 8297
Cyclooxygenase-2 196 Target ID: CHEMBL230 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D01823	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Eczema 46 Sources: http://www.rad-ar.or.jp/siori/english/kekka_plain.cgi?n=2254	Primary	Approved 8429	Fenazol Ointment 5% Approved Use It is usually used in the treatment of eczema, dermatitis and herpes zoster.
Dermatitis 10 Sources: http://www.rad-ar.or.jp/siori/english/kekka_plain.cgi?n=2254	Primary	Approved 8429	Fenazol Ointment 5% Approved Use It is usually used in the treatment of eczema, dermatitis and herpes zoster.
Herpes zoster infections 15 Sources: http://www.rad-ar.or.jp/siori/english/kekka_plain.cgi?n=2254	Primary	Approved 8429	Fenazol Ointment 5% Approved Use It is usually used in the treatment of eczema, dermatitis and herpes zoster.

PubMed

Title	Date	PubMed
Penetration of Ufenamate into Intact, Stripped, or Delipidized Skin Using Different Vehicles.	2015	26424024

Patents

Sample Use Guides

In Vivo Use Guide

Apply as a topical preparation at 3% or 3.5%.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:57:37 GMT 2023` Edited by `admin` on `Fri Dec 15 15:57:37 GMT 2023`
Record UNII	8Z7O7C1SLZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

UFENAMATE

Official Name

English

COMBEC

Brand Name

English

UFENAMATE [JAN]

Common Name

English

Ufenamate [WHO-DD]

Common Name

English

ufenamate [INN]

Common Name

English

FLUFENAMIC ACID BUTYL ESTER [MI]

Common Name

English

BUTYL N-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYL)ANTHRANILATE

Systematic Name

English

Fenazol

Common Name

English

ETOFENAMATE IMPURITY B [EP IMPURITY]

Common Name

English

Butyl flufenamate

Common Name

English

FLUFENAMIC ACID BUTYL ESTER

Common Name

English

UFENAMATE [MART.]

Common Name

English

Butyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoat

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257