U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C18H18F3NO4
Molecular Weight 369.335
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETOFENAMATE

SMILES

OCCOCCOC(=O)C1=C(NC2=CC=CC(=C2)C(F)(F)F)C=CC=C1

InChI

InChIKey=XILVEPYQJIOVNB-UHFFFAOYSA-N
InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2

HIDE SMILES / InChI
Molecular Formula C18H18F3NO4
Molecular Weight 369.335
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.mims.com/india/drug/info/etofenamate?mtype=generic https://www.ncbi.nlm.nih.gov/pubmed/6983482

Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Inhibitor
8297
Inhibitor
8297
 53.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
Etofenamate

Approved Use

Etofenamate is an NSAID applied topically for the relief of pain and inflammation associated with musculoskeletal, joint and soft tissue disorders.
Palliative
Approved
8429
Etofenamate

Approved Use

Etofenamate is an NSAID applied topically for the relief of pain and inflammation associated with musculoskeletal, joint and soft tissue disorders.
PubMed

PubMed

TitleDatePubMed
[Results and assessment of photopatch testing in Spain: towards a new standard set of photoallergens].
2007 Mar
Topical etofenamate to facilitate venipuncture.
2007 Oct
[Etofenamate and the analgesic effect in the management of acute pain from spine in the emergency room].
2007 Sep-Oct
Allergic contact dermatitis to etofenamate. Cross-reaction to other nonsteroidal anti-inflammatory drugs.
2008 Feb
Allergic and photoallergic contact dermartitis from etofenamate: study of 14 cases.
2009 Aug
Influence of preemptive analgesia on pulmonary function and complications for laparoscopic cholecystectomy.
2009 Dec
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Patents

Patents

JP2002528495A
37
JP2011524416A
138

Sample Use Guides

In Vivo Use Guide
Intramuscular Pain and inflammation Adult: 1 g injected deeply in single doses. Topical/Cutaneous Pain and inflammation Adult: Apply 5% or 10% conc topically on affected area.
Route of Administration: Other
In Vitro Use Guide
PGE2 generation by rat peritoneal macrophages in MEM medium was dose-relatedly inhibited with etofenamate at the dosage range of 1 to 30 uM.
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:53:28 GMT 2023
Edited
by admin
on Sat Dec 16 17:53:28 GMT 2023
Record UNII
KZF0XM66JC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETOFENAMATE
EP   INN   MART.   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
ETOFENAMATE [EP MONOGRAPH]
Common Name English
ETOFENAMATE [MI]
Common Name English
ETOFENAMATE [JAN]
Common Name English
WHR-5020
Code English
2-(2-HYDROXYETHOXY)ETHYL N-(.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYL)ANTHRANILATE
Systematic Name English
TVX-485
Code English
TVX485
Code English
2-(2-HYDROXYETHOXY)ETHYL-N-(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLYL)ANTHRANILATE
Systematic Name English
BAY D 1107
Code English
BENZOIC ACID, 2-((3-(TRIFLUOROMETHYL)PHENYL)AMINO)-, 2-(2-HYDROXYETHOXY)ETHYL ESTER
Systematic Name English
BAYD-1107
Code English
ETOFENAMATE [USAN]
Common Name English
etofenamate [INN]
Common Name English
ETOFENAMATE [MART.]
Common Name English
BAY-D-1107
Code English
Etofenamate [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-ATC M02AA06
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
NCI_THESAURUS C257
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
WHO-VATC QM02AA06
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C80545
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
PUBCHEM
35375
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
INN
3359
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
DRUG BANK
DB08984
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
CAS
30544-47-9
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
MESH
C015207
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
DRUG CENTRAL
3211
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
USAN
Y-46
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
RXCUI
24608
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY RxNorm
FDA UNII
KZF0XM66JC
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
ECHA (EC/EINECS)
250-231-8
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
WIKIPEDIA
ETOFENAMATE
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
SMS_ID
100000092609
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
ChEMBL
CHEMBL1451633
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
MERCK INDEX
m5191
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY Merck Index
EVMPD
SUB07319MIG
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
EPA CompTox
DTXSID2045448
Created by admin on Sat Dec 16 17:53:29 GMT 2023 , Edited by admin on Sat Dec 16 17:53:29 GMT 2023
PRIMARY
Related Record Type Details
Structure of FLUFENAMIC ACID
IMPURITY -> PARENT
Structure of 3-(TRIFLUOROMETHYL)-N-PHENYLANILINE
IMPURITY -> PARENT
Structure of 2,2′-oxybis(ethylene) bis[2-[[3-(trifluoromethyl)phenyl]amino]benzoate]
IMPURITY -> PARENT
Structure of UFENAMATE
IMPURITY -> PARENT
Structure of 2-(2-butoxyethoxy)ethyl 2-[[3-(trifluoromethyl)phenyl]amino]benzoate
IMPURITY -> PARENT
Structure of DIETHYLENE GLYCOL
IMPURITY -> PARENT
Structure of β-Hydroxyethyl flufenamate
IMPURITY -> PARENT
Related Record Type Details
Structure of ETOFENAMATE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966