U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C20H21N7O3
Molecular Weight 407.4258
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIFORADENANT

SMILES

CC1=CC=C(O1)C2=C3N=NN(CC4=CC=CC(CO[C@H]5CCOC5)=N4)C3=NC(N)=N2

InChI

InChIKey=KURQKNMKCGYWRJ-HNNXBMFYSA-N
InChI=1S/C20H21N7O3/c1-12-5-6-16(30-12)17-18-19(24-20(21)23-17)27(26-25-18)9-13-3-2-4-14(22-13)10-29-15-7-8-28-11-15/h2-6,15H,7-11H2,1H3,(H2,21,23,24)/t15-/m0/s1

HIDE SMILES / InChI

Molecular Formula C20H21N7O3
Molecular Weight 407.4258
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models.
2018 Aug
A2AR Antagonism with CPI-444 Induces Antitumor Responses and Augments Efficacy to Anti-PD-(L)1 and Anti-CTLA-4 in Preclinical Models.
2018 Oct
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:25:08 GMT 2023
Edited
by admin
on Sat Dec 16 11:25:08 GMT 2023
Record UNII
8KFO2187CP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CIFORADENANT
INN   USAN  
Official Name English
CIFORADENANT [USAN]
Common Name English
V81444
Code English
CPI-444
Code English
3H-1,2,3-TRIAZOLO(4,5-D)PYRIMIDIN-5-AMINE, 7-(5-METHYL-2-FURANYL)-3-((6-((((3S)-TETRAHYDRO-3-FURANYL)OXY)METHYL)-2-PYRIDINYL)METHYL)-
Systematic Name English
Ciforadenant [WHO-DD]
Common Name English
V-81444
Code English
ciforadenant [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2139
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
Code System Code Type Description
PUBCHEM
44537963
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
PRIMARY
ChEMBL
CHEMBL3545288
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
PRIMARY
CAS
1202402-40-1
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
PRIMARY
SMS_ID
100000181100
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
PRIMARY
USAN
GH-60
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
PRIMARY
INN
10767
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
PRIMARY
NCI_THESAURUS
C125659
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
PRIMARY
FDA UNII
8KFO2187CP
Created by admin on Sat Dec 16 11:25:08 GMT 2023 , Edited by admin on Sat Dec 16 11:25:08 GMT 2023
PRIMARY
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