FENOXYPROPAZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H14N2O
Molecular Weight	166.2203
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(COC1=CC=CC=C1)NN

InChI

InChIKey=QNEXFJFTGQBXBJ-UHFFFAOYSA-N

InChI=1S/C9H14N2O/c1-8(11-10)7-12-9-5-3-2-4-6-9/h2-6,8,11H,7,10H2,1H3

HIDE SMILES / InChI

Molecular Formula	C9H14N2O
Molecular Weight	166.2203
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://books.google.ru/books?id=vhyjDQAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.ncbi.nlm.nih.gov/pubmed/14129290 | https://www.ncbi.nlm.nih.gov/pubmed/14254271

Phenoxypropazine is a monoamine oxidase inhibitor. It was used in the treatment of depression. Phenoxypropazine was introduced in 1961 and withdrawn after 5 years on the market due to dose- and time-unrelated liver damage not identified in animal experiments.

CNS Activity

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Monoamine oxidase 32 Target ID: CHEMBL2095205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/4401309	Inhibitor 8297		0.01 mM [Ki]

PubMed

Title	Date	PubMed
A preliminary study of phenoxypropazine in the treatment of depression.	1963 Apr	13928824
Preliminary report on phenoxypropazine.	1963 May	13956423
A COMPARISON OF PHENOXYPROPAZINE AND AMYTRYPTILINE IN DEPRESSION.	1963 Oct	14069469

Sample Use Guides

In Vivo Use Guide

10 mg twice daily

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:49 UTC 2023` Edited by `admin` on `Fri Dec 15 16:26:49 UTC 2023`
Record UNII	8E92V52324
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FENOXYPROPAZINE

Official Name

English

PHENOXYPROPAZINE [MI]

Common Name

English

(1-METHYL-2-PHENOXYETHYL)HYDRAZINE

Systematic Name

English

PHENOXYPROPAZINE

Common Name

English

fenoxypropazine [INN]

Common Name

English

HYDRAZINE, (1-METHYL-2-PHENOXYETHYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C667