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Details

Stereochemistry RACEMIC
Molecular Formula C9H14N2O.C4H4O4
Molecular Weight 282.2924
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FENOXYPROPAZINE MALEATE

SMILES

OC(=O)\C=C/C(O)=O.CC(COC1=CC=CC=C1)NN

InChI

InChIKey=SWGZHHCRMZDRSN-BTJKTKAUSA-N
InChI=1S/C9H14N2O.C4H4O4/c1-8(11-10)7-12-9-5-3-2-4-6-9;5-3(6)1-2-4(7)8/h2-6,8,11H,7,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

HIDE SMILES / InChI
Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE
Molecular Formula C9H14N2O
Molecular Weight 166.2203
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Phenoxypropazine is a monoamine oxidase inhibitor. It was used in the treatment of depression. Phenoxypropazine was introduced in 1961 and withdrawn after 5 years on the market due to dose- and time-unrelated liver damage not identified in animal experiments.

CNS Activity

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
 0.01 mM [Ki]
PubMed

PubMed

TitleDatePubMed
A COMPARISON OF PHENOXYPROPAZINE AND AMYTRYPTILINE IN DEPRESSION.
1963-10
Preliminary report on phenoxypropazine.
1963-05
A preliminary study of phenoxypropazine in the treatment of depression.
1963-04

Sample Use Guides

Substance Class Chemical
Created
by admin
on Mon Mar 31 22:50:49 GMT 2025
Edited
by admin
on Mon Mar 31 22:50:49 GMT 2025
Record UNII
RY8TWH8PRR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FENOXYPROPAZINE MALEATE
Common Name English
PHENOXYPROPAZINE MALEATE
MI  
Preferred Name English
DRAZINE
Brand Name English
HP 1275
Code English
HYDRAZINE, (1-METHYL-2-PHENOXYETHYL)-, (Z)-2-BUTENEDIOATE (1:1)
Systematic Name English
COMPOUND HP1275
Code English
HYDRAZINE, (1-METHYL-2-PHENOXYETHYL)-, MALEATE (1:1)
Systematic Name English
(1-METHYL-2-PHENOXYETHYL)HYDRAZINE MALEATE
Systematic Name English
HYDRAZINE, (1-METHYL-2-PHENOXYETHYL)-, MALEATE
Systematic Name English
COMPOUND 1275
Code English
HYDRAZINE, (1-METHYL-2-PHENOXYETHYL)-, (2Z)-2-BUTENEDIOATE (1:1)
Systematic Name English
PHENOXYPROPAZINE MALEATE [MI]
Common Name English
Code System Code Type Description
PUBCHEM
20838094
Created by admin on Mon Mar 31 22:50:49 GMT 2025 , Edited by admin on Mon Mar 31 22:50:49 GMT 2025
PRIMARY
FDA UNII
RY8TWH8PRR
Created by admin on Mon Mar 31 22:50:49 GMT 2025 , Edited by admin on Mon Mar 31 22:50:49 GMT 2025
PRIMARY
CAS
3941-06-8
Created by admin on Mon Mar 31 22:50:49 GMT 2025 , Edited by admin on Mon Mar 31 22:50:49 GMT 2025
PRIMARY
MERCK INDEX
m885
Created by admin on Mon Mar 31 22:50:49 GMT 2025 , Edited by admin on Mon Mar 31 22:50:49 GMT 2025
PRIMARY Merck Index
Related Record Type Details
Structure of FENOXYPROPAZINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of FENOXYPROPAZINE
ACTIVE MOIETY
NIH
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