AMIQUINSIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H12N2O2
Molecular Weight	204.2252
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC2=NC=CC(N)=C2C=C1OC

InChI

InChIKey=UZVYGOXJMRZJFK-UHFFFAOYSA-N

InChI=1S/C11H12N2O2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3,(H2,12,13)

HIDE SMILES / InChI

Molecular Formula	C11H12N2O2
Molecular Weight	204.2252
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5463588

Amiquinsin hydrochloride, 4-amino-6,7-dimethoxquinoline hydrochloride hydrate, is a drug, which exhibits hypotensive activity. Amiquinsin has a more prolonged hypotensive effect than the hydroxyquinoline.

Originator

Approval Year

PubMed

Title	Date	PubMed
Studies on the absorption, distribution, and elimination of amiquinsin hydrochloride, a hypotensive drug.	1970	5463588

Patents

Sample Use Guides

In Vivo Use Guide

Amiquinsin hydrochloride was administered orally (10-40 mg/kg) to dogs as crystalline material in gelatin capsules. The drug was also administered parenterally (intravenously or intramuscularly, 2.5-10 mg/kg) to dogs as a solution in 5% dextrose, pH 4.4 to 4.8. Drug solutions were infused intravenously at a rate of 1.91 ml/min and at doses ranging from 1.25 to 10.00 mg/kg per hr using a Harvard pump.

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:29:20 GMT 2023` Edited by `admin` on `Sat Dec 16 17:29:20 GMT 2023`
Record UNII	85HK85C137
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMIQUINSIN

Official Name

English

4-QUINOLINAMINE, 6,7-DIMETHOXY-

Systematic Name

English

amiquinsin [INN]

Common Name

English

4-AMINO-6,7-DIMETHOXYQUINOLINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C270