U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C11H12N2O2.ClH
Molecular Weight 240.686
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMIQUINSIN HYDROCHLORIDE ANHYDROUS

SMILES

Cl.COC1=C(OC)C=C2C(N)=CC=NC2=C1

InChI

InChIKey=OCDSLXKDJFGRRI-UHFFFAOYSA-N
InChI=1S/C11H12N2O2.ClH/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2;/h3-6H,1-2H3,(H2,12,13);1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C11H12N2O2
Molecular Weight 204.2252
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Amiquinsin hydrochloride, 4-amino-6,7-dimethoxquinoline hydrochloride hydrate, is a drug, which exhibits hypotensive activity. Amiquinsin has a more prolonged hypotensive effect than the hydroxyquinoline.

Approval Year

PubMed

PubMed

TitleDatePubMed
Isolation, identification, and synthesis of 4-amino-6,7-dimethoxy-3-quinolinol, the major metabolite of amiquinsin hydrochloride in rats and humans.
1980-07
Studies on the absorption, distribution, and elimination of amiquinsin hydrochloride, a hypotensive drug.
1970
Patents

Sample Use Guides

Amiquinsin hydrochloride was administered orally (10-40 mg/kg) to dogs as crystalline material in gelatin capsules. The drug was also administered parenterally (intravenously or intramuscularly, 2.5-10 mg/kg) to dogs as a solution in 5% dextrose, pH 4.4 to 4.8. Drug solutions were infused intravenously at a rate of 1.91 ml/min and at doses ranging from 1.25 to 10.00 mg/kg per hr using a Harvard pump.
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:09:57 GMT 2025
Edited
by admin
on Mon Mar 31 19:09:57 GMT 2025
Record UNII
YRF4CS601J
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
4-QUINOLINAMINE, 6,7-DIMETHOXY-, MONOHYDROCHLORIDE
Preferred Name English
AMIQUINSIN HYDROCHLORIDE ANHYDROUS
Common Name English
4-QUINOLINAMINE, 6,7-DIMETHOXY-, HYDROCHLORIDE (1:1)
Systematic Name English
4-AMINO-6,7-DIMETHOXYQUINOLINE HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
FDA UNII
YRF4CS601J
Created by admin on Mon Mar 31 19:09:57 GMT 2025 , Edited by admin on Mon Mar 31 19:09:57 GMT 2025
PRIMARY
EPA CompTox
DTXSID60168731
Created by admin on Mon Mar 31 19:09:57 GMT 2025 , Edited by admin on Mon Mar 31 19:09:57 GMT 2025
PRIMARY
SMS_ID
300000055061
Created by admin on Mon Mar 31 19:09:57 GMT 2025 , Edited by admin on Mon Mar 31 19:09:57 GMT 2025
PRIMARY
CAS
1696-79-3
Created by admin on Mon Mar 31 19:09:57 GMT 2025 , Edited by admin on Mon Mar 31 19:09:57 GMT 2025
PRIMARY
PUBCHEM
70695630
Created by admin on Mon Mar 31 19:09:57 GMT 2025 , Edited by admin on Mon Mar 31 19:09:57 GMT 2025
PRIMARY
Related Record Type Details
SOLVATE->ANHYDROUS
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY