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Details

Stereochemistry ABSOLUTE
Molecular Formula C20H24N2O3S
Molecular Weight 372.483
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DESACETYLDILTIAZEM

SMILES

CN(C)CCN1c2ccccc2S[C@@]([H])(c3ccc(cc3)OC)[C@]([H])(C1=O)O

InChI

InChIKey=NZHUXMZTSSZXSB-MOPGFXCFSA-N
InChI=1S/C20H24N2O3S/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14/h4-11,18-19,23H,12-13H2,1-3H3/t18-,19+/m1/s1

HIDE SMILES / InChI

Molecular Formula C20H24N2O3S
Molecular Weight 372.483
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

PubMed

PubMed

TitleDatePubMed
The influence of diltiazem versus cimetidine on propranolol metabolism.
1992 Dec
Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists.
1993 Aug 2
Anaphylatoxin C3a induces rapid protein phosphorylation in guinea pig platelets.
1994 Sep-Oct
Inhibitory effects of TA-993, a new 1,5-benzothiazepine derivative, on platelet aggregation.
1996 Apr
Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix.
1996 May 28
[Effect of diltiazem on concentration of cyclosporin metabolites in Sandimmune and Neoral treated kidney transplant patients].
1997 Oct 15
Probable diltiazem-induced acute interstitial nephritis.
1998 Jun
Lower incidence of liver graft rejection in patients on diltiazem plus cyclosporine therapy.
1998 Jun
Relative bioavailability of Cardizem CD and Tiazac controlled-release diltiazem dosage forms after single and multiple dosing in healthy volunteers.
1998 May
Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.
1999 Apr
The effect of calcium channel blockers on cerebral oxygenation during tracheal extubation.
2000 Aug
Effects of diltiazem on down-regulation of lymphocyte beta-adrenoceptors in patients with chronic congestive heart failure.
2000 Oct
An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.
2000 Sep
Slowing the progression of renal disease in diabetic patients.
2001 Apr
Pharmacokinetic interaction between tacrolimus and diltiazem: dose-response relationship in kidney and liver transplant recipients.
2002
Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.
2002 Oct
The role of calcium antagonists in chronic kidney disease.
2004 Mar
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Jun 26 06:57:15 UTC 2021
Edited
by admin
on Sat Jun 26 06:57:15 UTC 2021
Record UNII
849UT193YJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DESACETYLDILTIAZEM
WHO-DD  
Common Name English
1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-, (2S,3S)-
Systematic Name English
DESACETYLDILTIAZEM [WHO-DD]
Common Name English
DEACETYLDILTIAZEM
Common Name English
(+)-DESACETYLDILTIAZEM
Common Name English
DESACETYL DILTIAZEM [WHO-IP]
Common Name English
Code System Code Type Description
PUBCHEM
91638
Created by admin on Sat Jun 26 06:57:15 UTC 2021 , Edited by admin on Sat Jun 26 06:57:15 UTC 2021
PRIMARY
EVMPD
SUB112491
Created by admin on Sat Jun 26 06:57:15 UTC 2021 , Edited by admin on Sat Jun 26 06:57:15 UTC 2021
PRIMARY
MESH
C037769
Created by admin on Sat Jun 26 06:57:15 UTC 2021 , Edited by admin on Sat Jun 26 06:57:15 UTC 2021
PRIMARY
CAS
91602-22-1
Created by admin on Sat Jun 26 06:57:15 UTC 2021 , Edited by admin on Sat Jun 26 06:57:15 UTC 2021
SUPERSEDED
CAS
42399-40-6
Created by admin on Sat Jun 26 06:57:15 UTC 2021 , Edited by admin on Sat Jun 26 06:57:15 UTC 2021
PRIMARY
ECHA (EC/EINECS)
255-795-9
Created by admin on Sat Jun 26 06:57:15 UTC 2021 , Edited by admin on Sat Jun 26 06:57:15 UTC 2021
PRIMARY
FDA UNII
849UT193YJ
Created by admin on Sat Jun 26 06:57:15 UTC 2021 , Edited by admin on Sat Jun 26 06:57:15 UTC 2021
PRIMARY
Related Record Type Details
BINDER->LIGAND
Related Record Type Details
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