DEACETYLDILTIAZEM

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H24N2O3S
Molecular Weight	372.481
Optical Activity	( + )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)[C@@H]2SC3=CC=CC=C3N(CCN(C)C)C(=O)[C@@H]2O

InChI

InChIKey=NZHUXMZTSSZXSB-MOPGFXCFSA-N

InChI=1S/C20H24N2O3S/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14/h4-11,18-19,23H,12-13H2,1-3H3/t18-,19+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H24N2O3S
Molecular Weight	372.481
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
The influence of diltiazem versus cimetidine on propranolol metabolism.	1992 Dec	1487547
Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists.	1993 Aug 2	8236144
Anaphylatoxin C3a induces rapid protein phosphorylation in guinea pig platelets.	1994 Sep-Oct	8002292
Inhibitory effects of TA-993, a new 1,5-benzothiazepine derivative, on platelet aggregation.	1996 Apr	8635222
Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix.	1996 May 28	8643600
[Effect of diltiazem on concentration of cyclosporin metabolites in Sandimmune and Neoral treated kidney transplant patients].	1997 Oct 15	9446006
Probable diltiazem-induced acute interstitial nephritis.	1998 Jun	9640485
Lower incidence of liver graft rejection in patients on diltiazem plus cyclosporine therapy.	1998 Jun	9636582
Relative bioavailability of Cardizem CD and Tiazac controlled-release diltiazem dosage forms after single and multiple dosing in healthy volunteers.	1998 May	10099056
Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.	1999 Apr	10320950
Increased urinary cortisol and androgen metabolites in a young female with hypertension: partial glucocorticoid resistance syndrome.	2000	10894920
The effect of calcium channel blockers on cerebral oxygenation during tracheal extubation.	2000 Aug	10910846
Effects of diltiazem retard on ambulatory blood pressure and heart rate variability in patients with essential hypertension.	2000 Jun	10915232
The interaction of diltiazem with simvastatin.	2000 Mar	10741630
Effects of diltiazem on down-regulation of lymphocyte beta-adrenoceptors in patients with chronic congestive heart failure.	2000 Oct	11501046
An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.	2000 Sep	10950845
Slowing the progression of renal disease in diabetic patients.	2001 Apr	11302410
Pharmacokinetic interaction between tacrolimus and diltiazem: dose-response relationship in kidney and liver transplant recipients.	2002	12036394
Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.	2002 Oct	12419016
The role of calcium antagonists in chronic kidney disease.	2004 Mar	15202609

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:17:11 GMT 2023` Edited by `admin` on `Fri Dec 15 16:17:11 GMT 2023`
Record UNII	849UT193YJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEACETYLDILTIAZEM

Common Name

English

DILTIAZEM HYDROCHLORIDE IMPURITY F [EP IMPURITY]

Common Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-, (2S,3S)-

Systematic Name

English

(+)-DESACETYLDILTIAZEM

Common Name

English

DEACETYL-D-DILTIAZEM

Common Name

English

Desacetyldiltiazem [WHO-DD]

Common Name

English

DESACETYLDILTIAZEM [WHO-IP]

Common Name

English

DESACETYLDILTIAZEM

Common Name

English

Code System Code Type Description

PUBCHEM

91638