DEACETYLDILTIAZEM HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H24N2O3S.ClH
Molecular Weight	408.942
Optical Activity	( + )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DEACETYLDILTIAZEM HYDROCHLORIDE

Structure Search

SMILES

Cl.COC1=CC=C(C=C1)[C@@H]2SC3=CC=CC=C3N(CCN(C)C)C(=O)[C@@H]2O

InChI

InChIKey=XNQWAVFYFJXSHD-VOMIJIAVSA-N

InChI=1S/C20H24N2O3S.ClH/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14;/h4-11,18-19,23H,12-13H2,1-3H3;1H/t18-,19+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C20H24N2O3S
Molecular Weight	372.481
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Anaphylatoxin C3a induces rapid protein phosphorylation in guinea pig platelets.	1994 Sep-Oct	8002292
Inhibitory effects of TA-993, a new 1,5-benzothiazepine derivative, on platelet aggregation.	1996 Apr	8635222
Lower incidence of liver graft rejection in patients on diltiazem plus cyclosporine therapy.	1998 Jun	9636582
Clinical pharmacokinetics and pharmacodynamics of buspirone, an anxiolytic drug.	1999 Apr	10320950
Effects of diltiazem on down-regulation of lymphocyte beta-adrenoceptors in patients with chronic congestive heart failure.	2000 Oct	11501046
Pharmacokinetic interaction between tacrolimus and diltiazem: dose-response relationship in kidney and liver transplant recipients.	2002	12036394

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 12:01:31 GMT 2023` Edited by `admin` on `Sat Dec 16 12:01:31 GMT 2023`
Record UNII	ZQ8A4H7BT3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEACETYLDILTIAZEM HYDROCHLORIDE

Common Name

English

(2S-CIS)-5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE MONOHYDROCHLORIDE

Systematic Name

English

DESACETYLDILTIAZEM HYDROCHLORIDE

Common Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-, MONOHYDROCHLORIDE, (2S,3S)-

Systematic Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-, HYDROCHLORIDE (1:1), (2S,3S)-

Systematic Name

English

Code System Code Type Description

FDA UNII

ZQ8A4H7BT3