DEACETYLDILTIAZEM HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H24N2O3S.ClH
Molecular Weight	408.942
Optical Activity	( + )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DEACETYLDILTIAZEM HYDROCHLORIDE

Structure Search

SMILES

Cl.COC1=CC=C(C=C1)[C@@H]2SC3=CC=CC=C3N(CCN(C)C)C(=O)[C@@H]2O

InChI

InChIKey=XNQWAVFYFJXSHD-VOMIJIAVSA-N

InChI=1S/C20H24N2O3S.ClH/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14;/h4-11,18-19,23H,12-13H2,1-3H3;1H/t18-,19+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C20H24N2O3S
Molecular Weight	372.481
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
The influence of diltiazem versus cimetidine on propranolol metabolism.	1992 Dec	1487547
Inhibitory effects of TA-993, a new 1,5-benzothiazepine derivative, on platelet aggregation.	1996 Apr	8635222
Increased urinary cortisol and androgen metabolites in a young female with hypertension: partial glucocorticoid resistance syndrome.	2000	10894920
Effects of diltiazem retard on ambulatory blood pressure and heart rate variability in patients with essential hypertension.	2000 Jun	10915232
Effects of diltiazem on down-regulation of lymphocyte beta-adrenoceptors in patients with chronic congestive heart failure.	2000 Oct	11501046
An in vitro model for predicting in vivo inhibition of cytochrome P450 3A4 by metabolic intermediate complex formation.	2000 Sep	10950845
Slowing the progression of renal disease in diabetic patients.	2001 Apr	11302410
Pharmacokinetic interaction between tacrolimus and diltiazem: dose-response relationship in kidney and liver transplant recipients.	2002	12036394
The role of calcium antagonists in chronic kidney disease.	2004 Mar	15202609

Patents

Substance Class	Chemical Created by `admin` on `Tue Apr 01 17:48:12 GMT 2025` Edited by `admin` on `Tue Apr 01 17:48:12 GMT 2025`
Record UNII	ZQ8A4H7BT3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(2S-CIS)-5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE MONOHYDROCHLORIDE

Preferred Name

English

DEACETYLDILTIAZEM HYDROCHLORIDE

Common Name

English

DESACETYLDILTIAZEM HYDROCHLORIDE

Common Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-, MONOHYDROCHLORIDE, (2S,3S)-

Systematic Name

English

1,5-BENZOTHIAZEPIN-4(5H)-ONE, 5-(2-(DIMETHYLAMINO)ETHYL)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-, HYDROCHLORIDE (1:1), (2S,3S)-

Systematic Name

English

Code System Code Type Description

FDA UNII

ZQ8A4H7BT3