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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H43N5O13
Molecular Weight 585.6025
Optical Activity UNSPECIFIED
Defined Stereocenters 16 / 16
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMIKACIN

SMILES

NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

InChI

InChIKey=LKCWBDHBTVXHDL-RMDFUYIESA-N
InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1

HIDE SMILES / InChI

Molecular Formula C22H43N5O13
Molecular Weight 585.6025
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 16 / 16
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including http://www.drugbank.ca/drugs/DB00479

Amikacin, USP (as the sulfate) is a semi-synthetic aminoglycoside antibiotic derived from kanamycin. Amikacin "irreversibly" binds to specific 30S-subunit proteins and 16S rRNA. Amikacin inhibits protein synthesis by binding to the 30S ribosomal subunit to prevent the formation of an initiation complex with messenger RNA. Specifically Amikacin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. Amikacin is used for short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. Amikacin may also be used to treat Mycobacterium avium and Mycobacterium tuberculosis infections. Amikacin was used for the treatment of gram-negative pneumonia.

Originator

Curator's Comment: # Bristol-Myers Squibb

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
5.27 mM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Curative
AMIKACIN SULFATE

Approved Use

Amikacin sulfate injection is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. Amikacin sulfate is effective in bacterial septicemia (including neonatal sepsis).

Launch Date

1993
Curative
AMIKACIN SULFATE

Approved Use

Amikacin sulfate injection is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. Amikacin sulfate is effective in central nervous system infections (including meningitis)

Launch Date

1993
Curative
AMIKACIN SULFATE

Approved Use

Amikacin sulfate injection is indicated in the short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. Amikacin sulfate is effective in serious complicated and recurrent urinary tract infections due to these organisms.

Launch Date

1993
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
2.8 μg/mL
590 mg 1 times / day steady-state, respiratory
dose: 590 mg
route of administration: Respiratory
experiment type: STEADY-STATE
co-administered:
AMIKACIN serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
23.5 μg × h/mL
590 mg 1 times / day steady-state, respiratory
dose: 590 mg
route of administration: Respiratory
experiment type: STEADY-STATE
co-administered:
AMIKACIN serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
5.9 h
590 mg 1 times / day steady-state, respiratory
dose: 590 mg
route of administration: Respiratory
experiment type: STEADY-STATE
co-administered:
AMIKACIN serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
90%
590 mg 1 times / day steady-state, respiratory
dose: 590 mg
route of administration: Respiratory
experiment type: STEADY-STATE
co-administered:
AMIKACIN serum
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
15 mg/kg single, intravenous
Highest studied dose
Dose: 15 mg/kg
Route: intravenous
Route: single
Dose: 15 mg/kg
Sources:
healthy, 21-30 years
Health Status: healthy
Age Group: 21-30 years
Sources:
60 mg/kg single, respiratory
Highest studied dose
Dose: 60 mg/kg
Route: respiratory
Route: single
Dose: 60 mg/kg
Sources:
healthy, 21-30 years
Health Status: healthy
Age Group: 21-30 years
Sources:
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, 58.0 years (range: 16 - 61 years)
Health Status: unhealthy
Age Group: 58.0 years (range: 16 - 61 years)
Sex: M+F
Sources:
Disc. AE: Infective exacerbation of bronchiectasis, Dyspnea...
AEs leading to
discontinuation/dose reduction:
Infective exacerbation of bronchiectasis (6.8%)
Dyspnea (4.5%)
Cough (1 patient)
Oropharyngeal pain (1 patient)
Respiratory disorder (1 patient)
Pneumonia (1 patient)
Sources:
15 mg/kg 1 times / day multiple, intramuscular
Highest studied dose
Dose: 15 mg/kg, 1 times / day
Route: intramuscular
Route: multiple
Dose: 15 mg/kg, 1 times / day
Sources:
unhealthy, adult
Health Status: unhealthy
Age Group: adult
Sources:
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, adult
Other AEs: Hypersensitivity pneumonitis, Hemoptysis...
Other AEs:
Hypersensitivity pneumonitis
Hemoptysis
Bronchospasm
Sources:
AEs

AEs

AESignificanceDosePopulation
Cough 1 patient
Disc. AE
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, 58.0 years (range: 16 - 61 years)
Health Status: unhealthy
Age Group: 58.0 years (range: 16 - 61 years)
Sex: M+F
Sources:
Oropharyngeal pain 1 patient
Disc. AE
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, 58.0 years (range: 16 - 61 years)
Health Status: unhealthy
Age Group: 58.0 years (range: 16 - 61 years)
Sex: M+F
Sources:
Pneumonia 1 patient
Disc. AE
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, 58.0 years (range: 16 - 61 years)
Health Status: unhealthy
Age Group: 58.0 years (range: 16 - 61 years)
Sex: M+F
Sources:
Respiratory disorder 1 patient
Disc. AE
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, 58.0 years (range: 16 - 61 years)
Health Status: unhealthy
Age Group: 58.0 years (range: 16 - 61 years)
Sex: M+F
Sources:
Dyspnea 4.5%
Disc. AE
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, 58.0 years (range: 16 - 61 years)
Health Status: unhealthy
Age Group: 58.0 years (range: 16 - 61 years)
Sex: M+F
Sources:
Infective exacerbation of bronchiectasis 6.8%
Disc. AE
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, 58.0 years (range: 16 - 61 years)
Health Status: unhealthy
Age Group: 58.0 years (range: 16 - 61 years)
Sex: M+F
Sources:
Bronchospasm
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, adult
Hemoptysis
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, adult
Hypersensitivity pneumonitis
590 mg 1 times / day multiple, respiratory
Recommended
Dose: 590 mg, 1 times / day
Route: respiratory
Route: multiple
Dose: 590 mg, 1 times / day
Sources:
unhealthy, adult
PubMed

PubMed

TitleDatePubMed
Multiple nocardial abscesses of cerebrum, cerebellum and spinal cord, causing quadriplegia.
2001 Apr
Monotherapy with meropenem versus combination therapy with piperacillin plus amikacin as empiric therapy for neutropenic fever in children with lymphoma and solid tumors.
2001 Apr-Jun
Role of megalin in renal handling of aminoglycosides.
2001 Aug
Nonenteric Escherichia coli isolates from dogs: 674 cases (1990-1998).
2001 Feb 1
Objective method for differentiating between drug-induced vestibulotoxicity and cochleotoxicity.
2001 Jan
Carriage of class 1 integrons and antibiotic resistance in clinical isolates of Acinetobacter baumannii from northern Spain.
2001 Jan
Nosocomial pneumonia. Diagnostic and therapeutic considerations.
2001 Jan
Granulocyte colony-stimulating factor in the treatment of high-risk febrile neutropenia: a multicenter randomized trial.
2001 Jan 3
Applications of a copper microparticle-modified carbon fiber microdisk array electrode for the simultaneous determination of aminoglycoside antibiotics by capillary electrophoresis.
2001 Jan 5
Treatment and outcome of nocardia keratitis.
2001 Jul
Antibiotic susceptibility and phage typing of methicillin-resistant and -sensitive Staphylococcus aureus clinical isolates at three periods during 1991-1997.
2001 Jun
Cost-effectiveness of cefepime + netilmicin or ceftazidime + amikacin or meropenem monotherapy in febrile neutropenic children with malignancy in Turkey.
2001 Jun
Antibiotic resistance among Gram-negative non-fermentative bacteria at a teaching hospital in Saudi Arabia.
2001 Jun
Antimicrobial susceptibility of Pseudomonas aeruginosa: results of a UK survey and evaluation of the British Society for Antimicrobial Chemotherapy disc susceptibility test.
2001 Jun
Retinal vasculitis and posterior pole "hypopyons" as early signs of acute bacterial endophthalmitis.
2001 Jun
Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux.
2001 Jun
Pharmacokinetic longitudinal studies of antibiotics administered via a permanent intraosseous device in micropigs.
2001 Jun
Efficacy and tolerability of piperacillin/tazobactam versus ceftazidime in association with amikacin for treating nosocomial pneumonia in intensive care patients: a prospective randomized multicenter trial.
2001 Mar
Streptococcus agalactiae endocarditis and giant pyomyoma simulating ovarian cancer.
2001 May
Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies.
2001 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Intravenous Administration The individual dose, the total daily dose, and the total cumulative dose of amikacin sulfate are identical to the dose recommended for intramuscular administration. The solution for intravenous use is prepared by adding the contents of a 500 mg vial to 100 or 200 mL of sterile diluent such as 0.9% sodium chloride injection or 5% dextrose injection or any other compatible solutions listed below. The solution is administered to adults over a 30 to 60 minute period. The total daily dose should not exceed 15 mg/kg/day and may be divided into either 2 or 3 equally-divided doses at equally-divided intervals. Amikacin can also be given by inhalation - The usual dose for adults with CF is 250-500mg twice a day via nebulizer. http://torontoadultcf.com/medications/inhaled-amikacin
The recommended dosage for adults, children and older infants with normal renal function is 15 mg/kg/day divided into 2 or 3 equal doses administered at equally divided intervals, i.e., 7.5 mg/kg q12h or 5 mg/kg q8h. Treatment of patients in the heavier weight classes should not exceed 1.5 grams/day. When amikacin is indicated in newborns, it is recommended that a loading dose of 10 mg/kg be administered initially to be followed with 7.5 mg/kg every 12 hours. The usual duration of treatment is 7 to 10 days. It is desirable to limit the duration of treatment to short-term whenever feasible. The total daily dose by all routes of administration should not exceed 15 mg/kg/day.
Route of Administration: Intramuscular
In Vitro Use Guide
Curator's Comment: Eight P. aeruginosa isolates obtained from clinical samples of burned patients and standard strain ATCC 27853 were used. Amikacin at 4 ug/mL concentration induced lower rate of coccoid bacteria (55.05%). Amikacin had a strong bactericidal effect on coccoid bacteria at 8 ug/mL concentration.
Amikacin had a strong bactericidal effect on coccoid bacteria at 8 ug/mL concentration.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:46:49 GMT 2025
Edited
by admin
on Mon Mar 31 17:46:49 GMT 2025
Record UNII
84319SGC3C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BAY 41-6551
Preferred Name English
AMIKACIN
EP   HSDB   INN   MART.   MI   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
AMIKACIN [USP MONOGRAPH]
Common Name English
AMIKACIN [VANDF]
Common Name English
AMIKACIN [JAN]
Common Name English
LUKADIN
Common Name English
AMIKACIN [WHO-IP]
Common Name English
NSC-177001
Code English
AMIKACIN [MART.]
Common Name English
AMIKACIN [HSDB]
Common Name English
O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6))-N(SUP 3)-(4-AMINO-L-2-HYDROXYBUTYRYL)-2-DEOXY-L-STREPTAMINE
Common Name English
Amikacin [WHO-DD]
Common Name English
AMIKACIN [MI]
Common Name English
AMIKACIN [USP-RS]
Common Name English
AMIKACINUM [WHO-IP LATIN]
Common Name English
AMIKACIN [EP MONOGRAPH]
Common Name English
amikacin [INN]
Common Name English
POTENTOX
Common Name English
D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL-(1->4))-N(SUP 1)-(4-AMINO-2-HYDROXY-1-OXOBUTYL)-2-DEOXY-, (S)-
Common Name English
Classification Tree Code System Code
NDF-RT N0000175477
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
CFR 21 CFR 522.56
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
WHO-ATC D06AX12
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
FDA ORPHAN DRUG 342011
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
WHO-VATC QJ01GB06
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
LIVERTOX NBK548695
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
NDF-RT N0000007853
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
FDA ORPHAN DRUG 217305
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
WHO-VATC QD06AX12
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
WHO-ESSENTIAL MEDICINES LIST 6.2.4
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
FDA ORPHAN DRUG 507715
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
CFR 21 CFR 862.3035
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
WHO-ATC J01GB06
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
FDA ORPHAN DRUG 282109
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
WHO-ATC S01AA21
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
WHO-ATC J01RA06
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
NCI_THESAURUS C2363
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
WHO-VATC QS01AA21
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
Code System Code Type Description
WHO INTERNATIONAL PHARMACOPEIA
AMIKACIN
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY Description: White or almost white powder. Solubility: Freely soluble in water, practically insoluble in acetone R or ethanol (~750 g/l) TS. Category: Antibacterial. Storage: Amikacin should be kept in a tightly closed container, or if sterile, in a hermetically closed container. Labelling: The label states:- where applicable, that the substances is free from bacterial endotoxins,- where applicable, that the substance is sterile. Definition: Amikacin is a semi-synthetic product derived from a fermentation product, kanamycin A. Amikacin contains not less than 96.5% and not more than 102.0% (Assay, Method A) or not less than 98.5% and not more than 101.0% (Assay, Method B) of amikacin (C22H43N5O13), calculated with reference to the anhydrous substance.
NCI_THESAURUS
C61615
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
DRUG CENTRAL
157
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
WIKIPEDIA
AMIKACIN
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
ChEMBL
CHEMBL177
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
CAS
37517-28-5
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
RS_ITEM_NUM
1019508
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PRIMARY
SMS_ID
100000092483
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
MESH
D000583
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PRIMARY
HSDB
3583
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PRIMARY
EPA CompTox
DTXSID3022586
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PRIMARY
ECHA (EC/EINECS)
253-538-5
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PRIMARY
FDA UNII
84319SGC3C
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
NSC
177001
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
PUBCHEM
37768
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
LACTMED
Amikacin
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
EVMPD
SUB05431MIG
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
INN
3492
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PRIMARY
RXCUI
641
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PRIMARY RxNorm
CHEBI
2637
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
DRUG BANK
DB00479
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
MERCK INDEX
m1670
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY Merck Index
DAILYMED
84319SGC3C
Created by admin on Mon Mar 31 17:46:49 GMT 2025 , Edited by admin on Mon Mar 31 17:46:49 GMT 2025
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
BINDER->LIGAND
BINDING
Related Record Type Details
IMPURITY -> PARENT
IMPURITY -> PARENT
Amikacin is a semi-synthetic product derived from a fermentation product, kanamycin A. Amikacin contains not less than 96.5% and not more than 102.0% (Assay, Method A) or not less than 98.5% and not more than 101.0% (Assay, Method B) of amikacin (C22H43N5O13), calculated with reference to the anhydrous substance.
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC