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Details

Stereochemistry RACEMIC
Molecular Formula C26H31FN2O4
Molecular Weight 454.5337
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LIDANSERIN

SMILES

COC1=C(OCCCN2CCC(CC2)C(=O)C3=CC=C(F)C=C3)C=C(C=C1)C4CNC(=O)C4

InChI

InChIKey=JDYWZVJXSMADHP-UHFFFAOYSA-N
InChI=1S/C26H31FN2O4/c1-32-23-8-5-20(21-16-25(30)28-17-21)15-24(23)33-14-2-11-29-12-9-19(10-13-29)26(31)18-3-6-22(27)7-4-18/h3-8,15,19,21H,2,9-14,16-17H2,1H3,(H,28,30)

HIDE SMILES / InChI

Molecular Formula C26H31FN2O4
Molecular Weight 454.5337
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Lidanserin is a drug which acts as a combined 5-HT2A and α1-adrenergic receptor antagonist. In conscious spontaneously hypertensive rats intravenous injection of lidanserin caused dose-dependent blood pressure reductions. Lidanserin antagonises the excitatory effect of synaptically released 5-HT on central sympathoexcitatory neurons. Lidanserin is a potential antihypertensive compound which combines vasodilatatory effects due to selective alpha 1-receptor antagonistic action and platelet antiaggregatory, antivasospastic, and vasoprotective properties due to selective 5-HT2-receptor blockade.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

Single dose 0.3, 1.0 and 3.0 mg/kg
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:15:14 GMT 2023
Edited
by admin
on Fri Dec 15 16:15:14 GMT 2023
Record UNII
80O1E9JZLN
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LIDANSERIN
INN  
INN  
Official Name English
2-PYRROLIDINONE, 4-(3-(3-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)PROPOXY)-4-METHOXYPHENYL)-
Systematic Name English
lidanserin [INN]
Common Name English
ZK33839
Code English
4-(3-(3-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)PROPOXY)-4-METHOXYPHENYL)-2-PYRROLIDINONE
Common Name English
ZK-33839
Code English
(±)-4-(3-(3-(4-(P-FLUOROBENZOYL)PIPERIDINO)PROPOXY)-4-METHOXYPHENYL)-2-PYRROLIDINONE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C66885
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
Code System Code Type Description
INN
6498
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
PUBCHEM
68919
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
EVMPD
SUB08505MIG
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
SMS_ID
100000082290
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
EPA CompTox
DTXSID60868269
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
WIKIPEDIA
Lidanserin
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
CAS
73725-85-6
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
FDA UNII
80O1E9JZLN
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
NCI_THESAURUS
C80773
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
ChEMBL
CHEMBL1742467
Created by admin on Fri Dec 15 16:15:14 GMT 2023 , Edited by admin on Fri Dec 15 16:15:14 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY