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Details

Stereochemistry UNKNOWN
Molecular Formula C26H31FN2O4
Molecular Weight 454.5337
Optical Activity ( - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LIDANSERIN, (-)-

SMILES

COC1=C(OCCCN2CCC(CC2)C(=O)C3=CC=C(F)C=C3)C=C(C=C1)C4CNC(=O)C4

InChI

InChIKey=JDYWZVJXSMADHP-UHFFFAOYSA-N
InChI=1S/C26H31FN2O4/c1-32-23-8-5-20(21-16-25(30)28-17-21)15-24(23)33-14-2-11-29-12-9-19(10-13-29)26(31)18-3-6-22(27)7-4-18/h3-8,15,19,21H,2,9-14,16-17H2,1H3,(H,28,30)

HIDE SMILES / InChI

Molecular Formula C26H31FN2O4
Molecular Weight 454.5337
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Lidanserin is a drug which acts as a combined 5-HT2A and α1-adrenergic receptor antagonist. In conscious spontaneously hypertensive rats intravenous injection of lidanserin caused dose-dependent blood pressure reductions. Lidanserin antagonises the excitatory effect of synaptically released 5-HT on central sympathoexcitatory neurons. Lidanserin is a potential antihypertensive compound which combines vasodilatatory effects due to selective alpha 1-receptor antagonistic action and platelet antiaggregatory, antivasospastic, and vasoprotective properties due to selective 5-HT2-receptor blockade.

Approval Year

PubMed

PubMed

TitleDatePubMed

Sample Use Guides

Single dose 0.3, 1.0 and 3.0 mg/kg
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:52:21 GMT 2023
Edited
by admin
on Sat Dec 16 10:52:21 GMT 2023
Record UNII
UT82UYM4JY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LIDANSERIN, (-)-
Common Name English
2-PYRROLIDINONE, 4-(3-(3-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)PROPOXY)-4-METHOXYPHENYL)-, (-)-
Systematic Name English
Code System Code Type Description
FDA UNII
UT82UYM4JY
Created by admin on Sat Dec 16 10:52:21 GMT 2023 , Edited by admin on Sat Dec 16 10:52:21 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER
ENANTIOMER -> ENANTIOMER