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Details

Stereochemistry UNKNOWN
Molecular Formula C26H31FN2O4
Molecular Weight 454.5337
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LIDANSERIN, (+)-

SMILES

COC1=C(OCCCN2CCC(CC2)C(=O)C3=CC=C(F)C=C3)C=C(C=C1)C4CNC(=O)C4

InChI

InChIKey=JDYWZVJXSMADHP-UHFFFAOYSA-N
InChI=1S/C26H31FN2O4/c1-32-23-8-5-20(21-16-25(30)28-17-21)15-24(23)33-14-2-11-29-12-9-19(10-13-29)26(31)18-3-6-22(27)7-4-18/h3-8,15,19,21H,2,9-14,16-17H2,1H3,(H,28,30)

HIDE SMILES / InChI

Molecular Formula C26H31FN2O4
Molecular Weight 454.5337
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Lidanserin is a drug which acts as a combined 5-HT2A and α1-adrenergic receptor antagonist. In conscious spontaneously hypertensive rats intravenous injection of lidanserin caused dose-dependent blood pressure reductions. Lidanserin antagonises the excitatory effect of synaptically released 5-HT on central sympathoexcitatory neurons. Lidanserin is a potential antihypertensive compound which combines vasodilatatory effects due to selective alpha 1-receptor antagonistic action and platelet antiaggregatory, antivasospastic, and vasoprotective properties due to selective 5-HT2-receptor blockade.

Approval Year

PubMed

PubMed

TitleDatePubMed
Contribution of serotonergic systems to maintenance of blood pressure in anaesthetised normotensive Wistar Kyoto and conscious spontaneously hypertensive rats.
1988
Anxiolytics reverse the acceleration of ejaculation resulting from enforced intercopulatory intervals in rats.
1991 Apr

Sample Use Guides

Single dose 0.3, 1.0 and 3.0 mg/kg
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:12:26 GMT 2023
Edited
by admin
on Sat Dec 16 11:12:26 GMT 2023
Record UNII
HJN54GC3F6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LIDANSERIN, (+)-
Common Name English
2-PYRROLIDINONE, 4-(3-(3-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)PROPOXY)-4-METHOXYPHENYL)-, (+)-
Systematic Name English
Code System Code Type Description
PUBCHEM
68919
Created by admin on Sat Dec 16 11:12:26 GMT 2023 , Edited by admin on Sat Dec 16 11:12:26 GMT 2023
PRIMARY
FDA UNII
HJN54GC3F6
Created by admin on Sat Dec 16 11:12:26 GMT 2023 , Edited by admin on Sat Dec 16 11:12:26 GMT 2023
PRIMARY
CAS
132683-37-5
Created by admin on Sat Dec 16 11:12:26 GMT 2023 , Edited by admin on Sat Dec 16 11:12:26 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER
ENANTIOMER -> ENANTIOMER