Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C26H31FN2O4 |
| Molecular Weight | 454.5337 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(OCCCN2CCC(CC2)C(=O)C3=CC=C(F)C=C3)C=C(C=C1)C4CNC(=O)C4
InChI
InChIKey=JDYWZVJXSMADHP-UHFFFAOYSA-N
InChI=1S/C26H31FN2O4/c1-32-23-8-5-20(21-16-25(30)28-17-21)15-24(23)33-14-2-11-29-12-9-19(10-13-29)26(31)18-3-6-22(27)7-4-18/h3-8,15,19,21H,2,9-14,16-17H2,1H3,(H,28,30)
| Molecular Formula | C26H31FN2O4 |
| Molecular Weight | 454.5337 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Lidanserin is a drug which acts as a combined 5-HT2A and α1-adrenergic receptor antagonist. In conscious spontaneously hypertensive rats intravenous injection of lidanserin caused dose-dependent blood pressure reductions. Lidanserin antagonises the excitatory effect of synaptically released 5-HT on central sympathoexcitatory neurons. Lidanserin is a potential antihypertensive compound which combines vasodilatatory effects due to selective alpha 1-receptor antagonistic action and platelet antiaggregatory, antivasospastic, and vasoprotective properties due to selective 5-HT2-receptor blockade.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Contribution of serotonergic systems to maintenance of blood pressure in anaesthetised normotensive Wistar Kyoto and conscious spontaneously hypertensive rats. | 1988 |
|
| Pharmacological profile of a new potent 5-hydroxytryptamine (5-HT2) alpha 1-receptor antagonist. | 1988 Jun |
|
| Anxiolytics reverse the acceleration of ejaculation resulting from enforced intercopulatory intervals in rats. | 1991 Apr |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:12:26 GMT 2023
by
admin
on
Sat Dec 16 11:12:26 GMT 2023
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| Record UNII |
HJN54GC3F6
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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Systematic Name | English |
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68919
Created by
admin on Sat Dec 16 11:12:26 GMT 2023 , Edited by admin on Sat Dec 16 11:12:26 GMT 2023
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PRIMARY | |||
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HJN54GC3F6
Created by
admin on Sat Dec 16 11:12:26 GMT 2023 , Edited by admin on Sat Dec 16 11:12:26 GMT 2023
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132683-37-5
Created by
admin on Sat Dec 16 11:12:26 GMT 2023 , Edited by admin on Sat Dec 16 11:12:26 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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RACEMATE -> ENANTIOMER | |||
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ENANTIOMER -> ENANTIOMER |
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