VINCONATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H20N2O2
Molecular Weight	296.3636
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1CCC2=C3C1CC=C(N3C4=C2C=CC=C4)C(=O)OC

InChI

InChIKey=JWOSSISWAJNJIA-UHFFFAOYSA-N

InChI=1S/C18H20N2O2/c1-3-19-11-10-13-12-6-4-5-7-14(12)20-16(18(21)22-2)9-8-15(19)17(13)20/h4-7,9,15H,3,8,10-11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C18H20N2O2
Molecular Weight	296.3636
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12690640 | https://www.ncbi.nlm.nih.gov/pubmed/9062664

Vinconate possesses both encephalotropic and psychotropic properties. Animal experiments have shown that this compound could induce the facilitation of phosphatidylinositide (PI) turnover via the stimulation of muscarinic acetylcholine receptors. In addition, vinconate could lead to the direct activations of PIP2-specific and cytosolic phospholipase C. The drug was on the stage of preregistration for the treatment of cognition disorders in Japan. However, information about the further fate of this drug is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Classification and determination of pharmacodynamics of a new antihypoxidotic drug, vinconate, by pharmaco-EEG and psychometry.	1984 Jul	6476974
Vinconate, a cognitive enhancer, and PI turnover-phospholipase C systems in the brain.	1997 Feb	9062664
Effects of vinconate on scopolamine-induced memory impairment in rhesus monkeys.	2003 Feb	12690640
Susceptibility to Calcium Dysregulation during Brain Aging.	2009	20552053

Sample Use Guides

In Vivo Use Guide

In a double-blind, placebo-controlled study the encephalotropic and psychotropic properties of both orally and intravenously administered doses of vinconate. They received at weekly intervals randomized single oral doses of placebo, 40 mg, 80 mg and 160 mg vinconate orally as well as placebo and 30 mg vinconate intravenously

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:55:02 GMT 2023` Edited by `admin` on `Fri Dec 15 15:55:02 GMT 2023`
Record UNII	807MP0MJ61
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

VINCONATE

Official Name

English

CHANODESETHYLAPOVINCAMINE

Common Name

English

vinconate [INN]

Common Name

English

VINCONATE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796