Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C18H20N2O2 |
| Molecular Weight | 296.3636 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCN1CCC2=C3C1CC=C(N3C4=C2C=CC=C4)C(=O)OC
InChI
InChIKey=JWOSSISWAJNJIA-UHFFFAOYSA-N
InChI=1S/C18H20N2O2/c1-3-19-11-10-13-12-6-4-5-7-14(12)20-16(18(21)22-2)9-8-15(19)17(13)20/h4-7,9,15H,3,8,10-11H2,1-2H3
| Molecular Formula | C18H20N2O2 |
| Molecular Weight | 296.3636 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Vinconate possesses both encephalotropic and psychotropic properties. Animal experiments have shown that this compound could induce the facilitation of phosphatidylinositide (PI) turnover via the stimulation of muscarinic acetylcholine receptors. In addition, vinconate could lead to the direct activations of PIP2-specific and cytosolic phospholipase C. The drug was on the stage of preregistration for the treatment of cognition disorders in Japan. However, information about the further fate of this drug is not available.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Classification and determination of pharmacodynamics of a new antihypoxidotic drug, vinconate, by pharmaco-EEG and psychometry. | 1984 Jul |
|
| Vinconate, a cognitive enhancer, and PI turnover-phospholipase C systems in the brain. | 1997 Feb |
|
| Effects of vinconate on scopolamine-induced memory impairment in rhesus monkeys. | 2003 Feb |
|
| Susceptibility to Calcium Dysregulation during Brain Aging. | 2009 |
Sample Use Guides
In a double-blind, placebo-controlled study the encephalotropic and psychotropic properties of both orally and intravenously administered doses of vinconate. They received at weekly intervals randomized single oral doses of placebo, 40 mg, 80 mg and 160 mg vinconate orally as well as placebo and 30 mg vinconate intravenously
Route of Administration:
Other
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:27:12 GMT 2023
by
admin
on
Sat Dec 16 10:27:12 GMT 2023
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| Record UNII |
USR9X88XYU
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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USR9X88XYU
Created by
admin on Sat Dec 16 10:27:12 GMT 2023 , Edited by admin on Sat Dec 16 10:27:12 GMT 2023
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753420-20-1
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admin on Sat Dec 16 10:27:12 GMT 2023 , Edited by admin on Sat Dec 16 10:27:12 GMT 2023
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68896
Created by
admin on Sat Dec 16 10:27:12 GMT 2023 , Edited by admin on Sat Dec 16 10:27:12 GMT 2023
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| Related Record | Type | Details | ||
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RACEMATE -> ENANTIOMER |
