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Details

Stereochemistry UNKNOWN
Molecular Formula C18H20N2O2
Molecular Weight 296.3636
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of VINCONATE, (+)-

SMILES

CCN1CCC2=C3C1CC=C(N3C4=C2C=CC=C4)C(=O)OC

InChI

InChIKey=JWOSSISWAJNJIA-UHFFFAOYSA-N
InChI=1S/C18H20N2O2/c1-3-19-11-10-13-12-6-4-5-7-14(12)20-16(18(21)22-2)9-8-15(19)17(13)20/h4-7,9,15H,3,8,10-11H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C18H20N2O2
Molecular Weight 296.3636
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Vinconate possesses both encephalotropic and psychotropic properties. Animal experiments have shown that this compound could induce the facilitation of phosphatidylinositide (PI) turnover via the stimulation of muscarinic acetylcholine receptors. In addition, vinconate could lead to the direct activations of PIP2-specific and cytosolic phospholipase C. The drug was on the stage of preregistration for the treatment of cognition disorders in Japan. However, information about the further fate of this drug is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Classification and determination of pharmacodynamics of a new antihypoxidotic drug, vinconate, by pharmaco-EEG and psychometry.
1984 Jul
Vinconate, a cognitive enhancer, and PI turnover-phospholipase C systems in the brain.
1997 Feb
Effects of vinconate on scopolamine-induced memory impairment in rhesus monkeys.
2003 Feb
Susceptibility to Calcium Dysregulation during Brain Aging.
2009

Sample Use Guides

In a double-blind, placebo-controlled study the encephalotropic and psychotropic properties of both orally and intravenously administered doses of vinconate. They received at weekly intervals randomized single oral doses of placebo, 40 mg, 80 mg and 160 mg vinconate orally as well as placebo and 30 mg vinconate intravenously
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:27:12 GMT 2023
Edited
by admin
on Sat Dec 16 10:27:12 GMT 2023
Record UNII
USR9X88XYU
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
VINCONATE, (+)-
Common Name English
1H-INDOLO(3,2,1-DE)(1,5)NAPHTHYRIDINE-6-CARBOXYLIC ACID, 3-ETHYL-2,3,3A,4-TETRAHYDRO-, METHYL ESTER, (+)-
Systematic Name English
Code System Code Type Description
FDA UNII
USR9X88XYU
Created by admin on Sat Dec 16 10:27:12 GMT 2023 , Edited by admin on Sat Dec 16 10:27:12 GMT 2023
PRIMARY
CAS
753420-20-1
Created by admin on Sat Dec 16 10:27:12 GMT 2023 , Edited by admin on Sat Dec 16 10:27:12 GMT 2023
PRIMARY
PUBCHEM
68896
Created by admin on Sat Dec 16 10:27:12 GMT 2023 , Edited by admin on Sat Dec 16 10:27:12 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER