VINCONATE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H20N2O2.ClH
Molecular Weight	332.825
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN1CCC2=C3C1CC=C(N3C4=C2C=CC=C4)C(=O)OC

InChI

InChIKey=UVPBAANTIASPBO-UHFFFAOYSA-N

InChI=1S/C18H20N2O2.ClH/c1-3-19-11-10-13-12-6-4-5-7-14(12)20-16(18(21)22-2)9-8-15(19)17(13)20;/h4-7,9,15H,3,8,10-11H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C18H20N2O2
Molecular Weight	296.3636
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12690640 | https://www.ncbi.nlm.nih.gov/pubmed/9062664

Vinconate possesses both encephalotropic and psychotropic properties. Animal experiments have shown that this compound could induce the facilitation of phosphatidylinositide (PI) turnover via the stimulation of muscarinic acetylcholine receptors. In addition, vinconate could lead to the direct activations of PIP2-specific and cytosolic phospholipase C. The drug was on the stage of preregistration for the treatment of cognition disorders in Japan. However, information about the further fate of this drug is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Classification and determination of pharmacodynamics of a new antihypoxidotic drug, vinconate, by pharmaco-EEG and psychometry.	1984 Jul	6476974
Effects of vinconate on scopolamine-induced memory impairment in rhesus monkeys.	2003 Feb	12690640
Susceptibility to Calcium Dysregulation during Brain Aging.	2009	20552053

Sample Use Guides

In Vivo Use Guide

In a double-blind, placebo-controlled study the encephalotropic and psychotropic properties of both orally and intravenously administered doses of vinconate. They received at weekly intervals randomized single oral doses of placebo, 40 mg, 80 mg and 160 mg vinconate orally as well as placebo and 30 mg vinconate intravenously

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:24:02 GMT 2023` Edited by `admin` on `Sat Dec 16 08:24:02 GMT 2023`
Record UNII	H5MM0UO9N8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

VINCONATE HYDROCHLORIDE

Common Name

English

VINCONATE HYDROCHLORIDE [MI]

Common Name

English

OM-853

Code

English

VINCONATE HYDROCHLORIDE [JAN]

Common Name

English

1H-INDOLO(3,2,1-DE)(1,5)NAPHTHYRIDINE-6-CARBOXYLIC ACID, 3-ETHYL-2,3,3A,4-TETRAHYDRO-, METHYL ESTER, HYDROCHLORIDE (1:1)

Systematic Name

English

OC-340

Code

English

VINCONATE HYDROCHLORIDE, (±)-

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID60923044