Details
Stereochemistry | ACHIRAL |
Molecular Formula | C12H14N2 |
Molecular Weight | 186.253 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=C(C)C(CC2=CNC=N2)=CC=C1
InChI
InChIKey=RHDJRPPFURBGLQ-UHFFFAOYSA-N
InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)
Molecular Formula | C12H14N2 |
Molecular Weight | 186.253 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2111338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2984021 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Dormosedan Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Severe pruritus associated with epidural morphine and detomidine in a horse. | 2001 Apr |
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Equine thoracoscopy: normal anatomy and surgical technique. | 2001 May |
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Laparoscopic closure of the renosplenic space in standing horses. | 2001 Nov-Dec |
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Effects of treatment with oxytocin, xylazine butorphanol, guaifenesin, acepromazine, and detomidine on esophageal manometric pressure in conscious horses. | 2002 Dec |
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Evaluation of the bispectral index as an indicator of degree of central nervous system depression in isoflurane-anesthetized horses. | 2002 Mar |
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Effects of intravenous lidocaine on isoflurane concentration, physiological parameters, metabolic parameters and stress-related hormones in horses undergoing surgery. | 2003 May |
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Surgical management of rectal prolapse in an Indian rhinoceros (Rhinoceros unicornis). | 2004 Jun |
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Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis. | 2004 Jun 22 |
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Effects of antitussive agents administered before bronchoalveolar lavage in horses. | 2005 Aug |
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Standing sedation in African elephants (Loxodonta africana) using detomidine-butorphanol combinations. | 2005 Jun |
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Chemical immobilisation of wild banteng (Bos javanicus) in northern Australia using detomidine, tiletamine and zolazepam. | 2005 Oct |
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The effect of hyoscine on dobutamine requirement in spontaneously breathing horses anaesthetized with halothane. | 2006 May |
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Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon. | 2010 |
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Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy. | 2010 Aug |
Patents
Sample Use Guides
for horses:
Oral (gel): 0.04 mg/kg;
Intravenous or Intramuscular injection: 0.02-0.04 mg/kg
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9617754
The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.
Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:58:55 GMT 2025
by
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on
Mon Mar 31 17:58:55 GMT 2025
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Record UNII |
7N8K34P2XH
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Record Status |
Validated (UNII)
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Record Version |
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WHO-VATC |
QN05CM90
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NCI_THESAURUS |
C29709
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7N8K34P2XH
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22672
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DB11556
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C83664
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CHEMBL2110829
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7N8K34P2XH
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m4209
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DTXSID00227457
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DETOMIDINE
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C041255
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76631-46-4
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SALT/SOLVATE -> PARENT |
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