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Details

Stereochemistry ACHIRAL
Molecular Formula C12H14N2
Molecular Weight 186.253
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DETOMIDINE

SMILES

CC1=C(C)C(CC2=CNC=N2)=CC=C1

InChI

InChIKey=RHDJRPPFURBGLQ-UHFFFAOYSA-N
InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula C12H14N2
Molecular Weight 186.253
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Dormosedan

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Severe pruritus associated with epidural morphine and detomidine in a horse.
2001 Apr
Equine thoracoscopy: normal anatomy and surgical technique.
2001 May
Laparoscopic closure of the renosplenic space in standing horses.
2001 Nov-Dec
Effects of treatment with oxytocin, xylazine butorphanol, guaifenesin, acepromazine, and detomidine on esophageal manometric pressure in conscious horses.
2002 Dec
Evaluation of the bispectral index as an indicator of degree of central nervous system depression in isoflurane-anesthetized horses.
2002 Mar
Effects of intravenous lidocaine on isoflurane concentration, physiological parameters, metabolic parameters and stress-related hormones in horses undergoing surgery.
2003 May
Surgical management of rectal prolapse in an Indian rhinoceros (Rhinoceros unicornis).
2004 Jun
Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis.
2004 Jun 22
Effects of antitussive agents administered before bronchoalveolar lavage in horses.
2005 Aug
Standing sedation in African elephants (Loxodonta africana) using detomidine-butorphanol combinations.
2005 Jun
Chemical immobilisation of wild banteng (Bos javanicus) in northern Australia using detomidine, tiletamine and zolazepam.
2005 Oct
The effect of hyoscine on dobutamine requirement in spontaneously breathing horses anaesthetized with halothane.
2006 May
Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon.
2010
Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy.
2010 Aug
Patents

Sample Use Guides

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg
Route of Administration: Other
In Vitro Use Guide
The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:58:55 GMT 2025
Edited
by admin
on Mon Mar 31 17:58:55 GMT 2025
Record UNII
7N8K34P2XH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
1H-IMIDAZOLE, 4-((2,3-DIMETHYLPHENYL)METHYL)
Preferred Name English
DETOMIDINE
INN   MI  
INN  
Official Name English
detomidine [INN]
Common Name English
DETOMIDINE [MI]
Common Name English
4-(2,3-DIMETHYLBENZYL)IMIDAZOLE
Systematic Name English
Classification Tree Code System Code
WHO-VATC QN05CM90
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
NCI_THESAURUS C29709
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
Code System Code Type Description
FDA UNII
7N8K34P2XH
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
RXCUI
22672
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY RxNorm
DRUG BANK
DB11556
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
NCI_THESAURUS
C83664
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
ChEMBL
CHEMBL2110829
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
DAILYMED
7N8K34P2XH
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
MERCK INDEX
m4209
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID00227457
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
WIKIPEDIA
DETOMIDINE
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
PUBCHEM
56032
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
EVMPD
SUB07012MIG
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
MESH
C041255
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
CAS
76631-46-4
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
SMS_ID
100000083196
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
INN
5078
Created by admin on Mon Mar 31 17:58:55 GMT 2025 , Edited by admin on Mon Mar 31 17:58:55 GMT 2025
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY