DETOMIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2
Molecular Weight	186.253
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC1=C(C)C(CC2=CNC=N2)=CC=C1

InChI

InChIKey=RHDJRPPFURBGLQ-UHFFFAOYSA-N

InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula	C12H14N2
Molecular Weight	186.253
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2 adrenergic receptor 3	Agonist 2,752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619	Primary		Approved 8,583	Dormosedan

PubMed

Show entries

Title	Date	PubMed
Standing sedation in African elephants (Loxodonta africana) using detomidine-butorphanol combinations.	2005 Jun	17323566
Effect of defocused CO2 laser on equine tissue perfusion.	2006	16722304
Dissociative anaesthesia during field and hospital conditions for castration of colts.	2006	16722301
Gait pattern of the ataxic horse compared to sedated and nonsedated horses.	2006 Aug	17402459
Comparison of intraoperative pain responses following intratesticular or mesorchial injection of lidocaine in standing horses undergoing laparoscopic cryptorchidectomy.	2006 Dec 1	17144826

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Patents

Sample Use Guides

In Vivo Use Guide

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg

Route of Administration: Other

In Vitro Use Guide

The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.