DETOMIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2
Molecular Weight	186.253
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C)C(CC2=CNC=N2)=CC=C1

InChI

InChIKey=RHDJRPPFURBGLQ-UHFFFAOYSA-N

InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula	C12H14N2
Molecular Weight	186.253
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride |

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2 adrenergic receptor 3 Target ID: CHEMBL2111338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2984021	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride	Primary		Approved 8583	Dormosedan Approved Use Unknown

PubMed

Title	Date	PubMed
Total intravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery.	2010-10	20966270
Accidental poisoning with detomidine and butorphanol.	2010-09	20573843
Human exposures to immobilising agents: results of an online survey.	2010-08-28	20802186
Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy.	2010-08	20459483
Tachypnea and antipyresis in febrile horses after sedation with alpha-agonists.	2010-05-25	20492482
Anesthetic management of a white rhinoceros (Ceratotherium simum) undergoing an emergency exploratory celiotomy for colic.	2010-05	20456115
Immobilization and intravenous anesthesia in a Sumatran rhinoceros (Dicerorhinus sumatrensis).	2010-03	20722263
Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon.	2010	20445779
Plasma concentrations, behavioural and physiological effects following intravenous and intramuscular detomidine in horses.	2009-11	20095225
Effects of dobutamine on cardiac index and arterial blood pressure in isoflurane-anaesthetized horses under clinical conditions.	2009-08	19614840
Steroid hormone receptors ERalpha and PR characterised by immunohistochemistry in the mare adrenal gland.	2009-07-22	19624811
Analgesic effect of butorphanol in ponies following castration.	2009-07	19803050
Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses.	2009-07	19538573
Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse.	2009-05-07	19422714
Pharmacokinetics of detomidine administered to horses at rest and after maximal exercise.	2009-05	19642399
Pharmacokinetics of detomidine and its metabolites following intravenous and intramuscular administration in horses.	2009-04	19562897
Metabolism during anaesthesia and recovery in colic and healthy horses: a microdialysis study.	2009-03-10	19284560
Effect of detomidine on visceral and somatic nociception and duodenal motility in conscious adult horses.	2009-03	19239655
Comparison of azaperone-detomidine-butorphanol-ketamine and azaperone-tiletamine-zolazepam for anaesthesia in piglets.	2009-03	19239653
A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy.	2009-01	19121161
Vascular perfusion of reproductive organs in pony mares and heifers during sedation with detomidine or xylazine.	2009-01	19119960
Reversible immobilization of asiatic black bear (Ursus thibetanus) with detomidine-tiletamine-zolazepam and atipamezole.	2008-12	19110696
Development of a composite orthopaedic pain scale in horses.	2008-10	18061637
Radiographic parameters for diagnosing sand colic in horses.	2008-06-13	18554381
Use of multichannel electrointestinography for noninvasive assessment of myoelectrical activity in the cecum and large colon of horses.	2008-06	18518649
Metabolism before, during and after anaesthesia in colic and healthy horses.	2007-11-15	18001483
Sedation with detomidine and acepromazine influences the endoscopic evaluation of laryngeal function in horses.	2007-11	18065315
A point mutation in a herpesvirus polymerase determines neuropathogenicity.	2007-11	17997600
The cardiopulmonary effects of etorphine, azaperone, detomidine, and butorphanol in field-anesthetized white rhinoceroses (Ceratotherium simum).	2007-09	17939346
Left- and right-sided laparoscopic-assisted nephrectomy in standing horses with unilateral renal disease.	2007-08	17686131
The use of alpha-2 agonists in the equine practice: comparison between three molecules.	2007-08	17682902
Radiographic closure time of appendicular growth plates in the Icelandic horse.	2007-07-17	17640333
Caries in the infundibulum of the second upper premolar tooth in the horse.	2007-03-28	17391523
Detecting early kidney damage in horses with colic by measuring matrix metalloproteinase -9 and -2, other enzymes, urinary glucose and total proteins.	2007-01-23	17244354
Atipamezole in the management of detomidine overdose in a pony.	2007-01	17238965
The effects of detomidine, romifidine or acepromazine on echocardiographic measurements and cardiac function in normal horses.	2007-01	17238956
Comparison of intraoperative pain responses following intratesticular or mesorchial injection of lidocaine in standing horses undergoing laparoscopic cryptorchidectomy.	2006-12-01	17144826
The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation.	2006-11	17242481
Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells.	2006-11	17242478
Serial chemical restraint for treatment of decubitus ulcers in two neonatal white rhinoceroses (Ceratotherium simum).	2006-09	17319140
Gait pattern of the ataxic horse compared to sedated and nonsedated horses.	2006-08	17402459
Effect of head position on intraocular pressure in horses.	2006-07	16817748
Effects of xylazine, medetomidine, detomidine, and diazepam on sedation, heart and respiratory rates, and cloacal temperature in rock partridges (Alectoris graeca).	2006-06	17312791
The stress caused by laparoscopy in sheep and its alleviation.	2006-06	16751840
Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole.	2006-05	16706278
The effect of hyoscine on dobutamine requirement in spontaneously breathing horses anaesthetized with halothane.	2006-05	16634940
Clinical evaluation of intranasal benzodiazepines, alpha-agonists and their antagonists in canaries.	2006-05	16634939
Effect of defocused CO2 laser on equine tissue perfusion.	2006	16722304
Dissociative anaesthesia during field and hospital conditions for castration of colts.	2006	16722301
Standing sedation in African elephants (Loxodonta africana) using detomidine-butorphanol combinations.	2005-06	17323566

Patents

Sample Use Guides

In Vivo Use Guide

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg

Route of Administration: Other

In Vitro Use Guide

The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:58:55 GMT 2025` Edited by `admin` on `Mon Mar 31 17:58:55 GMT 2025`
Record UNII	7N8K34P2XH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1H-IMIDAZOLE, 4-((2,3-DIMETHYLPHENYL)METHYL)

Preferred Name

English

DETOMIDINE

Official Name

English

detomidine [INN]

Common Name

English

DETOMIDINE [MI]

Common Name

English

4-(2,3-DIMETHYLBENZYL)IMIDAZOLE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QN05CM90