U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C12H14N2
Molecular Weight 186.2534
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DETOMIDINE

SMILES

Cc1cccc(Cc2cnc[nH]2)c1C

InChI

InChIKey=RHDJRPPFURBGLQ-UHFFFAOYSA-N
InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula C12H14N2
Molecular Weight 186.2534
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Dormosedan

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Comparison of detomidine and romifidine as premedicants before ketamine and halothane anesthesia in horses undergoing elective surgery.
2001 Mar
Sedation and chemical restraint of deer.
2002 Dec
In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus.
2002 Dec
The effects of xylazine, detomidine, acepromazine and butorphanol on equine solid phase gastric emptying rate.
2002 Jul
Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopy.
2002 May-Jun
Arthroscopic removal of dorsoproximal chip fractures of the proximal phalanx in standing horses.
2002 May-Jun
Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro.
2002 Oct
Aberrations in uterine contractile patterns in mares with delayed uterine clearance after administration of detomidine and oxytocin.
2002 Sep
A comparison of the antinociceptive effects of xylazine, detomidine and romifidine on experimental pain in horses.
2003 Jul
Flash electroretinography in standing horses using the DTL microfiber electrode.
2003 Mar
Effects of alpha-2 adrenoceptor agonists during recovery from isoflurane anaesthesia in horses.
2003 Mar
Interleukin-1 (IL-1) system gene expression in granulosa cells: kinetics during terminal preovulatory follicle maturation in the mare.
2003 May 16
Comparison of etorphine-detomidine and medetomidine-ketamine anesthesia in captive addax (Addax nasomaculatus).
2003 Sep
Chemical immobilization of captive aardvark (Orycteropus afer).
2004 Dec
Cardiovascular effects of insufflation of the abdomen with carbon dioxide in standing horses sedated with detomidine.
2004 Mar
Effects of antitussive agents administered before bronchoalveolar lavage in horses.
2005 Aug
Accidental human poisoning with a veterinary tranquilliser.
2005 Jul
Muscle metabolic changes associated with long-term inhalation anaesthesia in the horse analysed by muscle biopsy and microdialysis techniques.
2005 Mar
Dissociative anaesthesia during field and hospital conditions for castration of colts.
2006
Gait pattern of the ataxic horse compared to sedated and nonsedated horses.
2006 Aug
Sedative effects of midazolam and xylazine with or without ketamine and detomidine alone following intranasal administration in Ring-necked Parakeets.
2006 Feb 1
Clinical observations surrounding an increased incidence of postanesthetic myopathy in halothane-anesthetized horses.
2006 Mar
Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole.
2006 May
The effect of hyoscine on dobutamine requirement in spontaneously breathing horses anaesthetized with halothane.
2006 May
Left- and right-sided laparoscopic-assisted nephrectomy in standing horses with unilateral renal disease.
2007 Aug
The use of alpha-2 agonists in the equine practice: comparison between three molecules.
2007 Aug
Radiographic closure time of appendicular growth plates in the Icelandic horse.
2007 Jul 17
Caries in the infundibulum of the second upper premolar tooth in the horse.
2007 Mar 28
Sedation with detomidine and acepromazine influences the endoscopic evaluation of laryngeal function in horses.
2007 Nov
A point mutation in a herpesvirus polymerase determines neuropathogenicity.
2007 Nov
Metabolism before, during and after anaesthesia in colic and healthy horses.
2007 Nov 15
Reversible immobilization of asiatic black bear (Ursus thibetanus) with detomidine-tiletamine-zolazepam and atipamezole.
2008 Dec
Development of a composite orthopaedic pain scale in horses.
2008 Oct
A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy.
2009 Jan
Analgesic effect of butorphanol in ponies following castration.
2009 Jul
Comparison of the effects of the alpha-2 agonists detomidine, romifidine and xylazine on nociceptive withdrawal reflex and temporal summation in horses.
2009 Jul
Metabolism during anaesthesia and recovery in colic and healthy horses: a microdialysis study.
2009 Mar 10
Effect of sedation with detomidine and butorphanol on pulmonary gas exchange in the horse.
2009 May 7
Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon.
2010
Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy.
2010 Aug
Human exposures to immobilising agents: results of an online survey.
2010 Aug 28
Tachypnea and antipyresis in febrile horses after sedation with alpha-agonists.
2010 Jul-Aug
Immobilization and intravenous anesthesia in a Sumatran rhinoceros (Dicerorhinus sumatrensis).
2010 Mar
Anesthetic management of a white rhinoceros (Ceratotherium simum) undergoing an emergency exploratory celiotomy for colic.
2010 May
Total intravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery.
2010 Oct
Accidental poisoning with detomidine and butorphanol.
2010 Sep
Patents

Sample Use Guides

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg
Route of Administration: Other
In Vitro Use Guide
The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:13:46 UTC 2021
Edited
by admin
on Sat Jun 26 04:13:46 UTC 2021
Record UNII
7N8K34P2XH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DETOMIDINE
INN   MI  
INN  
Official Name English
1H-IMIDAZOLE, 4-((2,3-DIMETHYLPHENYL)METHYL)
Common Name English
DETOMIDINE [INN]
Common Name English
DETOMIDINE [MI]
Common Name English
4-(2,3-DIMETHYLBENZYL)IMIDAZOLE
Systematic Name English
Classification Tree Code System Code
WHO-VATC QN05CM90
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
NCI_THESAURUS C29709
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
Code System Code Type Description
FDA UNII
7N8K34P2XH
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
RXCUI
22672
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY RxNorm
DRUG BANK
DB11556
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
NCI_THESAURUS
C83664
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
ChEMBL
CHEMBL2110829
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
MERCK INDEX
M4209
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY Merck Index
EPA CompTox
76631-46-4
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
WIKIPEDIA
DETOMIDINE
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
PUBCHEM
56032
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
EVMPD
SUB07012MIG
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
MESH
C041255
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
CAS
76631-46-4
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
INN
5078
Created by admin on Sat Jun 26 04:13:46 UTC 2021 , Edited by admin on Sat Jun 26 04:13:46 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SHORT-ACTING
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY