DETOMIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2
Molecular Weight	186.253
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C)C(CC2=CNC=N2)=CC=C1

InChI

InChIKey=RHDJRPPFURBGLQ-UHFFFAOYSA-N

InChI=1S/C12H14N2/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12/h3-5,7-8H,6H2,1-2H3,(H,13,14)

HIDE SMILES / InChI

Molecular Formula	C12H14N2
Molecular Weight	186.253
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride |

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2 adrenergic receptor 3 Target ID: CHEMBL2111338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2984021	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride	Primary		Approved 8583	Dormosedan Approved Use Unknown

PubMed

Title	Date	PubMed
Severe pruritus associated with epidural morphine and detomidine in a horse.	2001 Apr	11349409
Equine thoracoscopy: normal anatomy and surgical technique.	2001 May	11352343
Laparoscopic closure of the renosplenic space in standing horses.	2001 Nov-Dec	11704952
Effects of treatment with oxytocin, xylazine butorphanol, guaifenesin, acepromazine, and detomidine on esophageal manometric pressure in conscious horses.	2002 Dec	12492291
Evaluation of the bispectral index as an indicator of degree of central nervous system depression in isoflurane-anesthetized horses.	2002 Mar	11911581
Effects of intravenous lidocaine on isoflurane concentration, physiological parameters, metabolic parameters and stress-related hormones in horses undergoing surgery.	2003 May	12948155
Surgical management of rectal prolapse in an Indian rhinoceros (Rhinoceros unicornis).	2004 Jun	15305523
Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis.	2004 Jun 22	15212696
Effects of antitussive agents administered before bronchoalveolar lavage in horses.	2005 Aug	16173487
Standing sedation in African elephants (Loxodonta africana) using detomidine-butorphanol combinations.	2005 Jun	17323566
Chemical immobilisation of wild banteng (Bos javanicus) in northern Australia using detomidine, tiletamine and zolazepam.	2005 Oct	16255285
The effect of hyoscine on dobutamine requirement in spontaneously breathing horses anaesthetized with halothane.	2006 May	16634940
Histological and immunohistochemical evaluation of autologous cultured bone marrow mesenchymal stem cells and bone marrow mononucleated cells in collagenase-induced tendinitis of equine superficial digital flexor tendon.	2010	20445779
Comparison of intraoperative behavioral and hormonal responses to noxious stimuli between mares sedated with caudal epidural detomidine hydrochloride or a continuous intravenous infusion of detomidine hydrochloride for standing laparoscopic ovariectomy.	2010 Aug	20459483

Patents

Sample Use Guides

In Vivo Use Guide

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg

Route of Administration: Other

In Vitro Use Guide

The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:58:55 GMT 2025` Edited by `admin` on `Mon Mar 31 17:58:55 GMT 2025`
Record UNII	7N8K34P2XH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1H-IMIDAZOLE, 4-((2,3-DIMETHYLPHENYL)METHYL)

Preferred Name

English

DETOMIDINE

Official Name

English

detomidine [INN]

Common Name

English

DETOMIDINE [MI]

Common Name

English

4-(2,3-DIMETHYLBENZYL)IMIDAZOLE

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QN05CM90