DETOMIDINE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14N2.ClH
Molecular Weight	222.714
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC1=C(C)C(CC2=CNC=N2)=CC=C1

InChI

InChIKey=OIWRDXKNDCJZSM-UHFFFAOYSA-N

InChI=1S/C12H14N2.ClH/c1-9-4-3-5-11(10(9)2)6-12-7-13-8-14-12;/h3-5,7-8H,6H2,1-2H3,(H,13,14);1H

HIDE SMILES / InChI

Molecular Formula	C12H14N2
Molecular Weight	186.253
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride |

Detomodine hydrochloride is a sedative with analgesic properties and α2-adrenergic agonist The dose-dependent sedative and analgesic effects reduce production of excitatory neurotransmitters, thereby calming the horse, relieving abdominal pain, and facilitating bronchoscopy and other procedures. Currently, detomidine is only licensed for use in horses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Alpha-2 adrenergic receptor 3 Target ID: CHEMBL2111338 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2984021	Agonist 2752

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: http://equimed.com/drugs-and-medications/reference/detomidine-hydrochloride	Primary		Approved 8583	Dormosedan Approved Use Unknown

PubMed

Title	Date	PubMed
Sedation and chemical restraint of deer.	2002 Dec	16032278
The effects of xylazine, detomidine, acepromazine and butorphanol on equine solid phase gastric emptying rate.	2002 Jul	12358052
N-Glucuronidation of some 4-arylalkyl-1H-imidazoles by rat, dog, and human liver microsomes.	2002 Mar	11854148
Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopy.	2002 May-Jun	11994850
Gait pattern of the ataxic horse compared to sedated and nonsedated horses.	2006 Aug	17402459
Effects of xylazine, medetomidine, detomidine, and diazepam on sedation, heart and respiratory rates, and cloacal temperature in rock partridges (Alectoris graeca).	2006 Jun	17312791
Electroencephalographic and electromyographic changes during the use of detomidine and detomidine-butorphanol combination in standing horses.	2006 Mar	16613024
Clinical observations surrounding an increased incidence of postanesthetic myopathy in halothane-anesthetized horses.	2006 Mar	16476002
The effect of hyoscine on dobutamine requirement in spontaneously breathing horses anaesthetized with halothane.	2006 May	16634940
Left- and right-sided laparoscopic-assisted nephrectomy in standing horses with unilateral renal disease.	2007 Aug	17686131
The use of alpha-2 agonists in the equine practice: comparison between three molecules.	2007 Aug	17682902
Radiographic closure time of appendicular growth plates in the Icelandic horse.	2007 Jul 17	17640333
Caries in the infundibulum of the second upper premolar tooth in the horse.	2007 Mar 28	17391523
Sedation with detomidine and acepromazine influences the endoscopic evaluation of laryngeal function in horses.	2007 Nov	18065315
A point mutation in a herpesvirus polymerase determines neuropathogenicity.	2007 Nov	17997600
The cardiopulmonary effects of etorphine, azaperone, detomidine, and butorphanol in field-anesthetized white rhinoceroses (Ceratotherium simum).	2007 Sep	17939346
Effects of dobutamine on cardiac index and arterial blood pressure in isoflurane-anaesthetized horses under clinical conditions.	2009 Aug	19614840
Vascular perfusion of reproductive organs in pony mares and heifers during sedation with detomidine or xylazine.	2009 Jan	19119960
Effect of detomidine on visceral and somatic nociception and duodenal motility in conscious adult horses.	2009 Mar	19239655
Total intravenous anesthesia with midazolam, ketamine, and xylazine or detomidine following induction with tiletamine, zolazepam, and xylazine in red deer (Cervus elaphus hippelaphus) undergoing surgery.	2010 Oct	20966270

Patents

Sample Use Guides

In Vivo Use Guide

for horses: Oral (gel): 0.04 mg/kg; Intravenous or Intramuscular injection: 0.02-0.04 mg/kg

Route of Administration: Other

In Vitro Use Guide

The sedative alpha2-adrenoceptor agonists medetomidine and detomidine inhibited aldosterone release (range 10-1000 nM). The 4-substituted imidazoles atipamezole, detomidine, and medetomidine inhibited mitochondrial cytochrome P450(11beta/18) in vitro.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:09:00 GMT 2025` Edited by `admin` on `Mon Mar 31 18:09:00 GMT 2025`
Record UNII	95K4LKB6QE
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DETOMIDINE HYDROCHLORIDE FOR VETERINARY USE

Preferred Name

English

DETOMIDINE HYDROCHLORIDE

Official Name

English

DETOMIDINE HYDROCHLORIDE [MI]

Common Name

English

DETOMIDINE HYDROCHLORIDE FOR VETERINARY USE [EP MONOGRAPH]

Common Name

English

DETOMIDINE HYDROCHLORIDE [GREEN BOOK]

Common Name

English

DETOMIDINE HYDROCHLORIDE [MART.]

Common Name

English

1H-IMIDAZOLE, 4-((2,3-DIMETHYLPHENYL)METHYL)-, MONOHYDROCHLORIDE

Common Name

English

MPV-253 AII

Code

English

DETOMIDINE HCL

Common Name

English

DETOMIDINE HYDROCHLORIDE [USAN]

Common Name

English

4-(2,3-Dimethylbenzyl)imidazole monohydrochloride

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 522.536