ASTROMICIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H35N5O6
Molecular Weight	405.4897
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]1(CC[C@@H](N)[C@@]([H])(O[C@@H]2[C@@H](N)[C@H](O)[C@H](OC)[C@H]([C@H]2O)N(C)C(=O)CN)O1)[C@H](C)N

InChI

InChIKey=BIDUPMYXGFNAEJ-APGVDKLISA-N

InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C17H35N5O6
Molecular Weight	405.4897
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://sdic.sookmyung.ac.kr/drug_monograph/view.asp?id=99
Curator's Comment: description was created based on several sources, including: http://www.et97.com/view/526697.htm

Astromicin is an aminoglycoside antibiotic produced by Micromonospora spp. It is effective against major gram-negative bacterias such as Proteus, Serratia, Citrobacter, Enterobacter spp., Klebsiella, Escherichia coli and Staphylococcus aureus. Astromicin sulfate has been given by intramuscular injection or intravenous infusion. Side effects are: rash, urticaria, itch, erythema, fever, nausea, vomiting, and diarrhea. Combination with strong diuretics can cause nephrotoxicity and ototoxicity.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Bacterial 70S ribosome 179 Target ID: CHEMBL2363135 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6395800	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Bronchitis 51 Sources: http://sdic.sookmyung.ac.kr/drug_monograph/view.asp?id=99	Curative	Approved 8429	Fortimicin Approved Use It is used for treatment of bronchitis
Pyelonephritis 5 Sources: http://sdic.sookmyung.ac.kr/drug_monograph/view.asp?id=99	Curative	Approved 8429	Fortimicin Approved Use It is used for treatment of pyelonephritis
Cystitis 27 Sources: http://sdic.sookmyung.ac.kr/drug_monograph/view.asp?id=99	Curative	Approved 8429	Fortimicin Approved Use It is used for treatment of cystitis.
Pneumonia 90 Sources: http://sdic.sookmyung.ac.kr/drug_monograph/view.asp?id=99	Curative	Approved 8429	Fortimicin Approved Use It is used for the treatment of pneumonia.
Peritonitis 22 Sources: http://sdic.sookmyung.ac.kr/drug_monograph/view.asp?id=99	Curative	Approved 8429	Fortimicin Approved Use It is used for treatment of peritonitis.

PubMed

Title	Date	PubMed
Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit.	2001	11598419
[Functional characterization of a multiple-antibiotic resistant plasmid from clinical isolates of methicillin-resistant Staphylococcus aureus].	2001 May	11424487
Photorhabdus luminescens genes induced upon insect infection.	2008 May 19	18489737

Patents

Sample Use Guides

In Vivo Use Guide

400mg divided into 2 injection

Route of Administration: Intramuscular

In Vitro Use Guide

MIC50 against Pseudomonas aeruginosa is 10 ug/ml

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:40:12 GMT 2023` Edited by `admin` on `Fri Dec 15 15:40:12 GMT 2023`
Record UNII	7JHD84H15J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ASTROMICIN

Official Name

English

FORTIMICIN A [MI]

Common Name

English

Astromicin [WHO-DD]

Common Name

English

astromicin [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2363