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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H35N5O6.2H2O4S
Molecular Weight 601.647
Optical Activity UNSPECIFIED
Defined Stereocenters 10 / 10
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ASTROMICIN SULFATE

SMILES

OS(O)(=O)=O.OS(O)(=O)=O.[H][C@]1(CC[C@@H](N)[C@@]([H])(O[C@@H]2[C@@H](N)[C@H](O)[C@H](OC)[C@H]([C@H]2O)N(C)C(=O)CN)O1)[C@H](C)N

InChI

InChIKey=TYNZVWXDLOJTIM-QQFWICJTSA-N
InChI=1S/C17H35N5O6.2H2O4S/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18;2*1-5(2,3)4/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3;2*(H2,1,2,3,4)/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+;;/m0../s1

HIDE SMILES / InChI
Molecular Formula H2O4S
Molecular Weight 98.078
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C17H35N5O6
Molecular Weight 405.4897
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 10 / 10
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: description was created based on several sources, including: http://www.et97.com/view/526697.htm

Astromicin is an aminoglycoside antibiotic produced by Micromonospora spp. It is effective against major gram-negative bacterias such as Proteus, Serratia, Citrobacter, Enterobacter spp., Klebsiella, Escherichia coli and Staphylococcus aureus. Astromicin sulfate has been given by intramuscular injection or intravenous infusion. Side effects are: rash, urticaria, itch, erythema, fever, nausea, vomiting, and diarrhea. Combination with strong diuretics can cause nephrotoxicity and ototoxicity.

Originator

Abbott
92
Curator's Comment: Fortimicin B:https://www.google.ch/patents/US3931400

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Binding Agent
1064
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Approved
8429
Fortimicin

Approved Use

It is used for treatment of bronchitis
Curative
Approved
8429
Fortimicin

Approved Use

It is used for treatment of pyelonephritis
Curative
Approved
8429
Fortimicin

Approved Use

It is used for treatment of cystitis.
Curative
Approved
8429
Fortimicin

Approved Use

It is used for the treatment of pneumonia.
Curative
Approved
8429
Fortimicin

Approved Use

It is used for treatment of peritonitis.
PubMed

PubMed

TitleDatePubMed
Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit.
2001
[Functional characterization of a multiple-antibiotic resistant plasmid from clinical isolates of methicillin-resistant Staphylococcus aureus].
2001 May
Photorhabdus luminescens genes induced upon insect infection.
2008 May 19
Patents

Patents

20050084448
2
20060182687
2
JPS5488244A
2
JPS5640697A
2

Sample Use Guides

In Vivo Use Guide
400mg divided into 2 injection
Route of Administration: Intramuscular
In Vitro Use Guide
MIC50 against Pseudomonas aeruginosa is 10 ug/ml
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:00:06 GMT 2023
Edited
by admin
on Fri Dec 15 15:00:06 GMT 2023
Record UNII
POY3S0T3BD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ASTROMICIN SULFATE
MART.   USAN   WHO-DD  
USAN  
Official Name English
L-CHIRO-INOSITOL, 4-AMINO-1-((AMINOACETYL)METHYLAMINO)-1,4-DIDEOXY-3-O-(2,6-DIAMINO-2,3,4,6,7-PENTADEOXY-.BETA.-L-LYXO-HEPTOPYRANOSYL)-6-O-METHYLSULFATE (1:2) (SALT)
Common Name English
ASTROMICIN SULFATE [USAN]
Common Name English
4-AMINO-1-(2-AMINO-N-METHYLACETAMIDO)-1,4-DIDEOXY-3-O-(2,6-DIAMINO-2,3,4,6,7-PENTADEOXY-.BETA.-L-LYXO-HEPTOPYRANOSYL)-6-O-METHYL-L-CHIRO-INOSITOL SULPHATE (1:2) (SALT)
Common Name English
FORTIMICIN A SULPHATE
Common Name English
FORTIMICIN A SULFATE
Common Name English
Astromicin sulfate [WHO-DD]
Common Name English
FORTIMICIN
Brand Name English
ASTROMICIN SULFATE [MART.]
Common Name English
L-CHIRO-INOSITOL, 4-AMINO-1-((AMINOACETYL)METHYLAMINO)-1,4-DIDEOXY-3-O-(2,6-DIAMINO-2,3,4,6,7-PENTADEOXY-.BETA.-L-LYXO-HEPTOPYRANOSYL)-6-O-METHYLSULPHATE (1:2) (SALT)
Common Name English
4-AMINO-1-(2-AMINO-N-METHYLACETAMIDO)-1,4-DIDEOXY-3-O-(2,6-DIAMINO-2,3,4,6,7-PENTADEOXY-.BETA.-L-LYXO-HEPTOPYRANOSYL)-6-O-METHYL-L-CHIRO-INOSITOL SULFATE (1:2) (SALT)
Common Name English
ASTROMICIN SULFATE [JAN]
Common Name English
ASTROMICIN SULPHATE
Common Name English
ABBOTT-44747
Code English
Classification Tree Code System Code
NCI_THESAURUS C2363
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL3084803
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
MESH
C023384
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
EPA CompTox
DTXSID50993034
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
PUBCHEM
72734319
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
EVMPD
SUB00614MIG
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
CAS
72275-67-3
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
FDA UNII
POY3S0T3BD
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
SMS_ID
100000085343
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
NCI_THESAURUS
C76147
Created by admin on Fri Dec 15 15:00:06 GMT 2023 , Edited by admin on Fri Dec 15 15:00:06 GMT 2023
PRIMARY
Related Record Type Details
Structure of ASTROMICIN
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of ASTROMICIN
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