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Details

Stereochemistry RACEMIC
Molecular Formula C19H19N
Molecular Weight 261.3616
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PHENINDAMINE

SMILES

CN1CCC2=C(C1)C(c3ccccc3)c4ccccc24

InChI

InChIKey=ISFHAYSTHMVOJR-UHFFFAOYSA-N
InChI=1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3

HIDE SMILES / InChI

Molecular Formula C19H19N
Molecular Weight 261.3616
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment:: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18907211

Phenindamine (thephorin or 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene) a pyridindene derivative proved to be a potent antihistaminic. Phenindamine was used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
THEPHORIN

Approved Use

Phenindamine was used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

Launch Date

-7.1634243E11
PubMed

PubMed

TitleDatePubMed
Treatment of allergic and some other dermatoses with thephorin; a preliminary report.
1947 Aug
Thephorin in the treatment of disseminated neurodermatitis.
1948 Aug
Histamine and the antihistaminic drugs.
1950 May
Performance enhancement effects of d-amphetamine, methylphenidate, pipradrol and phenindamine in rats.
1976
The effects of phenindamine tartrate on sleepiness and psychomotor performance.
1992 Dec
The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor.
1995 Aug 18
Patents

Patents

Sample Use Guides

The maximum amount of phenindamine that you should take in 1 day is 75 mg.
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Jun 26 10:54:22 UTC 2021
Edited
by admin
on Sat Jun 26 10:54:22 UTC 2021
Record UNII
772BQ8KSST
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHENINDAMINE
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
2-METHYL-9-PHENYL-2,3,4,9-TETRAHYDRO-1-PYRIDINDENE
Common Name English
PHENINDAMINE [MI]
Common Name English
2,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-1H-INDENO(2,1-C)PYRIDINE
Systematic Name English
PHENINDAMINE [VANDF]
Common Name English
PHENINDAMINE [INN]
Common Name English
1,2,3,4-TETRAHYDRO-2-METHYL-9-PHENYL-2-AZAFLUORENE
Systematic Name English
PHENINDAMINE [WHO-DD]
Common Name English
NU-1504
Code English
THEPHORIN
Brand Name English
1H-INDENO(2,1-C)PYRIDINE, 2,3,4,9-TETRAHYDRO-2-METHYL-9-PHENYL-
Systematic Name English
Classification Tree Code System Code
WHO-VATC QR06AX04
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
NCI_THESAURUS C29578
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
WHO-ATC R06AX04
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C87745
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
ChEMBL
CHEMBL278398
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
FDA UNII
772BQ8KSST
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
INN
4170
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
LACTMED
Phenindamine
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
PUBCHEM
11291
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
RXCUI
33283
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY RxNorm
WIKIPEDIA
PHENINDAMINE
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
MERCK INDEX
M8617
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY Merck Index
DRUG BANK
DB01619
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
MESH
C005430
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
EPA CompTox
82-88-2
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
EVMPD
SUB09764MIG
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
CAS
82-88-2
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
ECHA (EC/EINECS)
201-443-4
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
DRUG CENTRAL
2129
Created by admin on Sat Jun 26 10:54:22 UTC 2021 , Edited by admin on Sat Jun 26 10:54:22 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
SALT/SOLVATE -> PARENT
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY