Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C19H19N.HNO3 |
| Molecular Weight | 324.3737 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O[N+]([O-])=O.CN1CCC2=C(C1)C(C3=CC=CC=C23)C4=CC=CC=C4
InChI
InChIKey=VNPBUNUBQYZEKS-UHFFFAOYSA-N
InChI=1S/C19H19N.HNO3/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14;2-1(3)4/h2-10,19H,11-13H2,1H3;(H,2,3,4)
| Molecular Formula | C19H19N |
| Molecular Weight | 261.3609 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | HNO3 |
| Molecular Weight | 63.0128 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18907211
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18907211
Phenindamine (thephorin or 2-methyl-9-phenyl-2,3,4,9-tetrahydro-1-pyridindene) a pyridindene derivative proved to be a potent antihistaminic. Phenindamine was used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL231 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | THEPHORIN Approved UsePhenindamine was used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold. Launch Date1947 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Treatment of allergic and some other dermatoses with thephorin; a preliminary report. | 1947 Aug |
|
| Thephorin in the treatment of disseminated neurodermatitis. | 1948 Aug |
|
| Histamine and the antihistaminic drugs. | 1950 May |
|
| Performance enhancement effects of d-amphetamine, methylphenidate, pipradrol and phenindamine in rats. | 1976 |
|
| The effects of phenindamine tartrate on sleepiness and psychomotor performance. | 1992 Dec |
|
| The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. | 1995 Aug 18 |
Patents
| Substance Class |
Chemical
Created
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Edited
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| Record UNII |
7EXK7X55BR
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| Record Status |
Validated (UNII)
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114226-44-7
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7EXK7X55BR
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admin on Sat Dec 16 19:55:21 GMT 2023 , Edited by admin on Sat Dec 16 19:55:21 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
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