Details
Stereochemistry | ACHIRAL |
Molecular Formula | C15H8ClF6NO2 |
Molecular Weight | 383.673 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(Cl)C=C1C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F
InChI
InChIKey=CHILCFMQWMQVAL-UHFFFAOYSA-N
InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
Molecular Formula | C15H8ClF6NO2 |
Molecular Weight | 383.673 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/16397257Curator's Comment: description was created based on several sources, including:
http://www.immd.co.jp/en/development.html | http://adisinsight.springer.com/drugs/800030091 | https://www.ncbi.nlm.nih.gov/pubmed/15194461
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16397257
Curator's Comment: description was created based on several sources, including:
http://www.immd.co.jp/en/development.html | http://adisinsight.springer.com/drugs/800030091 | https://www.ncbi.nlm.nih.gov/pubmed/15194461
IMD-0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells. IMD-0354 had been in phase I clinical trials for the treatment of atopic dermatitis.
Originator
Sources: http://www.immd.co.jp/en/development.html
Curator's Comment: http://adisinsight.springer.com/drugs/800030091
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2111328 |
250.0 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Preventing | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. | 2005 Mar 15 |
|
Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-kappaB pathway and interferon-gamma/dexamethasone. | 2007 |
|
Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms. | 2007 Aug |
|
Salicylanilide inhibitors of Toxoplasma gondii. | 2012 Oct 11 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15194461
Curator's Comment: http://www.immd.co.jp/en/development.html
1, 5, or 10 mg/kg intraperitoneal injection in a single bolus 5 min before the start of reperfusion.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15194461
IMD-0354 (0.1-1 uM) caused a significant reduction of both IL-1β (−77%) and MCP-1 (−76%) production in a concentration-dependent manner compared with vehicle-treated cells.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 07:58:30 GMT 2023
by
admin
on
Sat Dec 16 07:58:30 GMT 2023
|
Record UNII |
76145IS906
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
CHEMBL3545089
Created by
admin on Sat Dec 16 07:58:30 GMT 2023 , Edited by admin on Sat Dec 16 07:58:30 GMT 2023
|
PRIMARY | |||
|
DTXSID50243248
Created by
admin on Sat Dec 16 07:58:30 GMT 2023 , Edited by admin on Sat Dec 16 07:58:30 GMT 2023
|
PRIMARY | |||
|
978-62-1
Created by
admin on Sat Dec 16 07:58:30 GMT 2023 , Edited by admin on Sat Dec 16 07:58:30 GMT 2023
|
PRIMARY | |||
|
5081913
Created by
admin on Sat Dec 16 07:58:30 GMT 2023 , Edited by admin on Sat Dec 16 07:58:30 GMT 2023
|
PRIMARY | |||
|
76145IS906
Created by
admin on Sat Dec 16 07:58:30 GMT 2023 , Edited by admin on Sat Dec 16 07:58:30 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
TARGET -> INHIBITOR |
IC50
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |