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Inhibitor of NF-kappa-B kinase (IKK)

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Phase I

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Unknown

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Allergic asthma

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Atopic dermatitis

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Cancer

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Diabetic retinopathy

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Pulmonary arterial hypertension

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Preventing

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Institute of Medicinal Molecular Design

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METHYL 5-SULFAMOYL-O-ANISATE

F8XVA6KYT6

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

IMD-0354

76145IS906

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Inhibitor of NF-kappa-B kinase (IKK)

Conditions:

Diabetic retinopathy

Pulmonary arterial hypertension

Allergic asthma

Atopic dermatitis

IMD-0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine prod...

uction in cardiomyocytes. Induces G0/G1 cell cycle arrest and apoptosis in HMC-1 and breast cancer cells. IMD-0354 had been in phase I clinical trials for the treatment of atopic dermatitis.

PRENYLTHIOL

FDG262156U

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

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