Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H18F3N3O2 |
| Molecular Weight | 377.3603 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CCC(CC1)C(=O)C2=CC=CC(NC(=O)C3=C(F)C=C(F)C=C3F)=N2
InChI
InChIKey=XEDHVZKDSYZQBF-UHFFFAOYSA-N
InChI=1S/C19H18F3N3O2/c1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22/h2-4,9-11H,5-8H2,1H3,(H,23,24,27)
| Molecular Formula | C19H18F3N3O2 |
| Molecular Weight | 377.3603 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Acute treatment of migraine with the selective 5-HT1F receptor agonist lasmiditan--a randomised proof-of-concept trial. | 2010 Oct |
|
| Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan. | 2010 Oct |
|
| Molecule of the month. Lasmiditan hydrochloride. | 2010 Sep |
Patents
Sample Use Guides
Lasmiditan in vitro binding studies show a Ki value of 2.21 nM at the 5-HT(1F) serotonin receptor, compared with Ki values of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. Lasmiditan did not contract rabbit saphenous vein rings, a surrogate assay for human coronary artery constriction, at concentrations up to 100 uM.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Oct 21 19:54:32 UTC 2019
by
admin
on
Mon Oct 21 19:54:32 UTC 2019
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| Record UNII |
760I9WM792
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| Record Status |
Validated (UNII)
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| Record Version |
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9176
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LASMIDITAN
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11610526
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CHEMBL3039520
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439239-90-4
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admin on Mon Oct 21 19:54:32 UTC 2019 , Edited by admin on Mon Oct 21 19:54:32 UTC 2019
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439239-90-4
Created by
admin on Mon Oct 21 19:54:32 UTC 2019 , Edited by admin on Mon Oct 21 19:54:32 UTC 2019
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PRIMARY |
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
