U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2C19H18F3N3O2.C4H6O4
Molecular Weight 872.8103
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LASMIDITAN SUCCINATE

SMILES

CN1CCC(CC1)C(=O)c2cccc(n2)N=C(c3c(cc(cc3F)F)F)O.CN1CCC(CC1)C(=O)c2cccc(n2)N=C(c3c(cc(cc3F)F)F)O.C(CC(=O)O)C(=O)O

InChI

InChIKey=MSOIHUHNGPOCTH-UHFFFAOYSA-N
InChI=1S/2C19H18F3N3O2.C4H6O4/c2*1-25-7-5-11(6-8-25)18(26)15-3-2-4-16(23-15)24-19(27)17-13(21)9-12(20)10-14(17)22;5-3(6)1-2-4(7)8/h2*2-4,9-11H,5-8H2,1H3,(H,23,24,27);1-2H2,(H,5,6)(H,7,8)

HIDE SMILES / InChI

Molecular Formula C19H18F3N3O2
Molecular Weight 377.361
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C4H6O4
Molecular Weight 118.0882
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

LASMIDITAN is a serotonin (5-HT) receptor agonist without vasoconstrictor activity, which selectively binds to the 5-HT(1F) receptor subtype. It is under development for the treatment of migraine.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
2.10000000000000009 nM [Ki]
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
322.8 ng/mL
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LASMIDITAN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
394.7 ng/mL
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LASMIDITAN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
526.15 ng/mL
400 mg single, oral
dose: 400 mg
route of administration: oral
experiment type: single
co-administered:
LASMIDITAN unknown
Homo sapiens
population: healthy
age:
sex:
food status:
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
1892 ng × h/mL
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LASMIDITAN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FASTED
2244 ng × h/mL
200 mg single, oral
dose: 200 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
LASMIDITAN serum
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: FED
3189.08 ng*h/mL
400 mg single, oral
dose: 400 mg
route of administration: oral
experiment type: single
co-administered:
LASMIDITAN unknown
Homo sapiens
population: healthy
age:
sex:
food status:
Doses

Doses

DosePopulationAdverse events​
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Other AEs: Dizziness, Fatigue...
Other AEs:
Dizziness (15%)
Fatigue (5%)
Paresthesia (7%)
Sedation (6%)
Nausea and vomiting (4%)
Muscle weakness (1%)
Sources:
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Other AEs: Dizziness, Fatigue...
Other AEs:
Dizziness (17%)
Fatigue (6%)
Paresthesia (9%)
Sedation (7%)
Nausea and vomiting (4%)
Muscle weakness (2%)
Sources:
50 mg 1 times / day steady, oral
Recommended
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Other AEs: Dizziness, Fatigue...
Other AEs:
Dizziness (9%)
Fatigue (4%)
Paresthesia (3%)
Sedation (6%)
Nausea and vomiting (3%)
Muscle weakness (1%)
Sources:
120 mg 5 times / day single, oral
Highest studied dose
Dose: 120 mg, 5 times / day
Route: oral
Route: single
Dose: 120 mg, 5 times / day
Sources:
unhealthy, adults
400 mg 1 times / day single, oral
Highest studied dose
Dose: 400 mg, 1 times / day
Route: oral
Route: single
Dose: 400 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Disc. AE: Dizziness, Light headedness...
AEs leading to
discontinuation/dose reduction:
Dizziness (2.8%)
Light headedness (2.8%)
Somnolence (1.6%)
Sedation (1.6%)
Asthenia (0.7%)
Fatigue (0.7%)
Malaise (0.7%)
Weakness (0.7%)
Paresthesia (0.8%)
Hypoaesthesia (0.8%)
Nausea (0.7%)
Vomiting (0.7%)
Confusion (2.1%)
Delirium (2.1%)
Mental status changes (2.1%)
Disorientation (2.1%)
Sources:
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Disc. AE: Dizziness, Light headedness...
Other AEs: Confusion, Delirium...
AEs leading to
discontinuation/dose reduction:
Dizziness (4.2%)
Light headedness (4.2%)
Somnolence (1.2%)
Sedation (1.2%)
Asthenia (2.5%)
Fatigue (2.5%)
Malaise (2.5%)
Weakness (2.5%)
Paresthesia (1.8%)
Hypoaesthesia (1.8%)
Nausea (1.5%)
Vomiting (1.5%)
Confusion (1.4%)
Delirium (1.4%)
Mental status changes (1.4%)
Disorientation (1.4%)
Other AEs:
Confusion (1.4%)
Delirium (1.4%)
Mental status changes (1.4%)
Disorientation (1.4%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Muscle weakness 1%
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Dizziness 15%
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Nausea and vomiting 4%
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Fatigue 5%
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Sedation 6%
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Paresthesia 7%
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Dizziness 17%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Muscle weakness 2%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Nausea and vomiting 4%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Fatigue 6%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Sedation 7%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Paresthesia 9%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Muscle weakness 1%
50 mg 1 times / day steady, oral
Recommended
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Nausea and vomiting 3%
50 mg 1 times / day steady, oral
Recommended
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Paresthesia 3%
50 mg 1 times / day steady, oral
Recommended
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Fatigue 4%
50 mg 1 times / day steady, oral
Recommended
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Sedation 6%
50 mg 1 times / day steady, oral
Recommended
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Dizziness 9%
50 mg 1 times / day steady, oral
Recommended
Dose: 50 mg, 1 times / day
Route: oral
Route: steady
Dose: 50 mg, 1 times / day
Sources:
unhealthy, 18-81 years
Health Status: unhealthy
Age Group: 18-81 years
Sex: M+F
Sources:
Asthenia 0.7%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Fatigue 0.7%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Malaise 0.7%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Nausea 0.7%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Vomiting 0.7%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Weakness 0.7%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Hypoaesthesia 0.8%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Paresthesia 0.8%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Sedation 1.6%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Somnolence 1.6%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Confusion 2.1%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Delirium 2.1%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Disorientation 2.1%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Mental status changes 2.1%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Dizziness 2.8%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Light headedness 2.8%
Disc. AE
100 mg 1 times / day steady, oral
Recommended
Dose: 100 mg, 1 times / day
Route: oral
Route: steady
Dose: 100 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Sedation 1.2%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Somnolence 1.2%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Confusion 1.4%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Delirium 1.4%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Disorientation 1.4%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Mental status changes 1.4%
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Confusion 1.4%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Delirium 1.4%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Disorientation 1.4%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Mental status changes 1.4%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Nausea 1.5%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Vomiting 1.5%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Hypoaesthesia 1.8%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Paresthesia 1.8%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Asthenia 2.5%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Fatigue 2.5%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Malaise 2.5%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Weakness 2.5%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Dizziness 4.2%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
Light headedness 4.2%
Disc. AE
200 mg 1 times / day steady, oral
Recommended
Dose: 200 mg, 1 times / day
Route: oral
Route: steady
Dose: 200 mg, 1 times / day
Sources:
unhealthy, adults
Health Status: unhealthy
Age Group: adults
Sex: M+F
Sources:
OverviewDrug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
low
low
low
low
low
low
low
no (co-administration study)
Comment: "when administered with sumatriptan, no change in sumatriptan PK was observed; '""low potential of interactions"""
Page: 8, 18
no
no
no
no
no
no
no (co-administration study)
Comment: administered with caffeine, daily dosing of lasmiditan did not alter PK of caffeine
Page: 8
no
no (co-administration study)
Comment: administered with caffeine, daily dosing of lasmiditan did not alter PK of caffeine
Page: 8
no
no (co-administration study)
Comment: administered with tolbutamide, daily dosing of lasmiditan did not alter the PK of tolbutamide.
Page: 8
no
no (co-administration study)
Comment: administered with tolbutamide, daily dosing of lasmiditan did not alter the PK of tolbutamide.
Page: 8
no
no (co-administration study)
Comment: administered with midazolam, daily dosing of lasmiditan did not alter PK of midazolam
Page: 8
no
no (co-administration study)
Comment: administered with midazolam, daily dosing of lasmiditan did not alter PK of midazolam
Page: 8
yes [IC50 85 uM]
yes [Ki 20.7 uM]
yes
yes
yes
Drug as victimTox targets

Tox targets

PubMed

PubMed

TitleDatePubMed
Molecule of the month. Lasmiditan hydrochloride.
2010 Sep
Patents

Sample Use Guides

Lasmiditan in vitro binding studies show a Ki value of 2.21 nM at the 5-HT(1F) serotonin receptor, compared with Ki values of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. Lasmiditan did not contract rabbit saphenous vein rings, a surrogate assay for human coronary artery constriction, at concentrations up to 100 uM.
Substance Class Chemical
Created
by admin
on Sat Jun 26 07:54:09 UTC 2021
Edited
by admin
on Sat Jun 26 07:54:09 UTC 2021
Record UNII
W64YBJ346B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LASMIDITAN SUCCINATE
USAN   WHO-DD  
USAN  
Official Name English
LY683974
Code English
LY-683974
Code English
BUTANEDIOIC ACID, COMPD. WITH 2,4,6-TRIFLUORO-N-(6-((1-METHYL-4-PIPERIDINYL)CARBONYL)-2-PYRIDINYL)BENZAMIDE (1:2)
Common Name English
REYVOW
Brand Name English
2,4,6-TRIFLUORO-N-(6-((1-METHYLPIPERIDINE-4-YL)CARBONYL)PYRIDIN-2-YL)BENZAMIDE HEMISUCCINATE
Common Name English
LY573144
Code English
LASMIDITAN SUCCINATE [WHO-DD]
Common Name English
LY-573144
Code English
LASMIDITAN HEMISUCCINATE
Common Name English
LASMIDITAN SUCCINATE [USAN]
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL3039520
Created by admin on Sat Jun 26 07:54:10 UTC 2021 , Edited by admin on Sat Jun 26 07:54:10 UTC 2021
PRIMARY
EPA CompTox
439239-92-6
Created by admin on Sat Jun 26 07:54:10 UTC 2021 , Edited by admin on Sat Jun 26 07:54:10 UTC 2021
PRIMARY
FDA UNII
W64YBJ346B
Created by admin on Sat Jun 26 07:54:10 UTC 2021 , Edited by admin on Sat Jun 26 07:54:10 UTC 2021
PRIMARY
NCI_THESAURUS
C170094
Created by admin on Sat Jun 26 07:54:10 UTC 2021 , Edited by admin on Sat Jun 26 07:54:10 UTC 2021
PRIMARY
PUBCHEM
46927777
Created by admin on Sat Jun 26 07:54:10 UTC 2021 , Edited by admin on Sat Jun 26 07:54:10 UTC 2021
PRIMARY
CAS
439239-92-6
Created by admin on Sat Jun 26 07:54:10 UTC 2021 , Edited by admin on Sat Jun 26 07:54:10 UTC 2021
PRIMARY
DRUG BANK
DBSALT002893
Created by admin on Sat Jun 26 07:54:10 UTC 2021 , Edited by admin on Sat Jun 26 07:54:10 UTC 2021
PRIMARY
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PARENT -> SALT/SOLVATE
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