Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H27N3O3 |
| Molecular Weight | 405.4895 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(OC)C=C2C(CCN3C(=O)N(C)C(C=C23)=NC4=C(C)C=C(C)C=C4C)=C1
InChI
InChIKey=MCMSJVMUSBZUCN-UHFFFAOYSA-N
InChI=1S/C24H27N3O3/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4/h9-13H,7-8H2,1-6H3
| Molecular Formula | C24H27N3O3 |
| Molecular Weight | 405.4895 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12016266 | https://www.ncbi.nlm.nih.gov/pubmed/2544722 | https://www.ncbi.nlm.nih.gov/pubmed/3526628
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12016266 | https://www.ncbi.nlm.nih.gov/pubmed/2544722 | https://www.ncbi.nlm.nih.gov/pubmed/3526628
Trequinsin is a potent PDE3 inhibitor that inhibits PDE4 and PDE2 at higher concentrations. Trequinsin can block platelet aggregation and also inhibit tissue factor expression in human endothelial cells. Trequinsin can enhance cellular cAMP content, forskolin-induced cAMP synthesis, and renin release in cells.
Originator
Approval Year
Sample Use Guides
Rat (male Sprague-Dawley, 80 g) JG cells were isolated as for mouse JG cells by enzymatic digestion of renal cortex with collagenase A (Roche Diagnostics, Denmark) and trypsin (Sigma, Denmark), followed by filtration and wash. JG-cell suspensions were seeded in 1-mL aliquots and incubated with agents (1 and 10 mkmol/L of the Trequinsin) for 10 minutes. The cells were harvested in cold ethanol with 20 mmol/L HCl. After evaporation, cAMP was measured by RIA (Amersham-Biotrak RPA509).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:00:23 UTC 2023
by
admin
on
Sat Dec 16 05:00:23 UTC 2023
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| Record UNII |
739I2958C1
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| Record Status |
Validated (UNII)
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| Record Version |
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| Name | Type | Language | ||
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Official Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C744
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| Code System | Code | Type | Description | ||
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SUB11240MIG
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C152731
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739I2958C1
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C035964
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5193
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DTXSID2048458
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100000077485
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79855-88-2
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5537
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Trequinsin
Created by
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CHEMBL285913
Created by
admin on Sat Dec 16 05:00:23 UTC 2023 , Edited by admin on Sat Dec 16 05:00:23 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> INHIBITOR |
IC50
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TARGET -> INHIBITOR |
IC50
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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