SELEGILINE HYDROCHLORIDE

First approved in 1989

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C13H17N.ClH
Molecular Weight	223.742
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.C[C@H](CC1=CC=CC=C1)N(C)CC#C

InChI

InChIKey=IYETZZCWLLUHIJ-UTONKHPSSA-N

InChI=1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C13H17N
Molecular Weight	187.2808
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugs.com/dosage/selegiline.html
Curator's Comment: description was created based on several sources, including https://www.drugbank.ca/drugs/DB01037 | https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021708s000_021336s000lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/18237459 | https://www.ncbi.nlm.nih.gov/pubmed/28108387

Selegiline, also known as L-deprenyl, is a substituted phenethylamine, a selective, irreversible inhibitor of Type B monoamine oxidase. Selegiline is available in pill form under many brand names (Eldepryl, Carbex, Atapryl) and is used to reduce symptoms in early-stage Parkinson's disease. Selegiline delays the time point when the L-DOPA (levodopa) treatment becomes necessary from about 11 months to about 18 months after diagnosis, which is beneficial despite not being definitive evidence of neuroprotection. The rationale for adding selegiline to levodopa is to decrease the required dose of levodopa and thus reduce the motor complications of levodopa therapy. Selegiline is also delivered via a transdermal patch (brand name, Emsam) and in this form, Selegiline is used as a treatment for the major depressive disorder. Selegiline (brand name Anipryl) is also used (at extremely high dosages relative to humans) in veterinary medicine to treat the symptoms of Cushing's disease and cognitive dysfunction (Canine Cognitive Dysfunction) in dogs. Side effects of the pill form include, in decreasing order of frequency, nausea, hallucinations, confusion, depression, loss of balance, insomnia, increased involuntary movements, agitation, arrhythmia, slow heart rate, delusions, hypertension, new or increased angina pectoris, and syncope. The main side effects of the patch form for depression included application site reactions, insomnia, diarrhea, and sore throat.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Monoamine oxidase B 72 Target ID: CHEMBL2039 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26337020	Inhibitor 8228		9.0 nM [IC50]
Monoamine oxidase A 49 Target ID: CHEMBL1951 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26278660	Inhibitor 8228		47.9 nM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Parkinson's disease 225 Sources: https://www.drugs.com/dosage/selegiline.html	Primary	Approved 8360	EMSAM Approved Use Selegiline Hydrochloride Tablets USP are indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy. Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of 'off' time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state). Launch Date 1.14099841E12
Major depressive disorder 172 Sources: https://www.drugs.com/dosage/selegiline.html	Primary	Approved 8360	EMSAM Approved Use Selegiline Hydrochloride Tablets USP are indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy. Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of 'off' time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state). Launch Date 1.14099841E12
Bipolar depression 9 Sources: https://www.drugs.com/dosage/selegiline.html	Primary	Approved 8360	EMSAM Approved Use Selegiline Hydrochloride Tablets USP are indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy. Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of 'off' time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state). Launch Date 1.14099841E12
Cocaine-related disorders 19 Sources: https://clinicaltrials.gov/ct2/show/NCT00032929	Primary	Phase III 663	EMSAM Approved Use Selegiline Hydrochloride Tablets USP are indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy. Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of 'off' time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state). Launch Date 1.14099841E12
Cognitive disorders 8 Sources: https://clinicaltrials.gov/ct2/show/NCT00002154	Primary	Phase II 1144	EMSAM Approved Use Selegiline Hydrochloride Tablets USP are indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy. Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa. Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of 'off' time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state). Launch Date 1.14099841E12

C_max

Value	Dose	Co-administered	Analyte	Population
8.9 ng/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/10215747	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:		SELEGILINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
11 ng × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/10215747	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:		SELEGILINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.3 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021479s005lbl.pdf	1.25 mg single, oral dose: 1.25 mg route of administration: Oral experiment type: SINGLE co-administered:		SELEGILINE plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN
1.8 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/10215747	10 mg single, oral dose: 10 mg route of administration: Oral experiment type: SINGLE co-administered:		SELEGILINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
15% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021479s005lbl.pdf	1.25 mg single, oral dose: 1.25 mg route of administration: Oral experiment type: SINGLE co-administered:		SELEGILINE plasma	Homo sapiens population: UNKNOWN age: ADULT sex: UNKNOWN food status: UNKNOWN

Doses

Dose	Population	Adverse events
12 mg 1 times / day multiple, transdermal Highest studied dose Dose: 12 mg, 1 times / day Route: transdermal Route: multiple Dose: 12 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17568687/	unhealthy, adult n = 116 Health Status: unhealthy Condition: major depressive disorder Age Group: adult Sex: M+F Population Size: 116 Sources: https://pubmed.ncbi.nlm.nih.gov/17568687/	Other AEs: Headache, Infection... Other AEs: Headache (16%) Infection (15%) Back pain (6%) Diarrhea (11%) Nausea (7%) Insomnia (32%) Dry mouth (13%) Dizziness (14%) Nervousness (10%) Somnolence (5%) Anxiety (5%) Abnormal dreams (5%) Pharyngitis (7%) Application site reaction (44%) Sources: https://pubmed.ncbi.nlm.nih.gov/17568687/
12 mg 1 times / day multiple, transdermal (max) Recommended Dose: 12 mg, 1 times / day Route: transdermal Route: multiple Dose: 12 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/17568687/	unhealthy, adult n = 817 Health Status: unhealthy Condition: major depressive disorder Age Group: adult Sex: M+F Population Size: 817 Sources: https://pubmed.ncbi.nlm.nih.gov/17568687/	Other AEs: Headache, Infection... Other AEs: Headache (18%) Infection (9%) Back pain (3%) Diarrhea (9%) Nausea (5%) Insomnia (12%) Dry mouth (8%) Dizziness (5%) Nervousness (4%) Somnolence (3%) Anxiety (3%) Abnormal dreams (2%) Pharyngitis (3%) Application site reaction (24%) Sources: https://pubmed.ncbi.nlm.nih.gov/17568687/
2.5 mg 1 times / day multiple, oral Recommended Dose: 2.5 mg, 1 times / day Route: oral Route: multiple Dose: 2.5 mg, 1 times / day Co-administed with:: levodopa Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021479s003s004lbl.pdf	unhealthy, adult n = 194 Health Status: unhealthy Condition: Parkinson’s disease Age Group: adult Sex: M+F Population Size: 194 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021479s003s004lbl.pdf	Other AEs: Back pain, Chest pain... Other AEs: Back pain (5%) Chest pain (2%) Pain (8%) Hypertension (3%) Constipation (4%) Diarrhea (2%) Dysphagia (2%) Dyspepsia (5%) Flatulence (2%) Nausea (11%) Stomatitis (5%) Tooth disorder (2%) Vomiting (3%) Ecchymosis (2%) Hypokalemia (2%) Leg cramps (3%) Myalgia (3%) Ataxia (3%) Depression (2%) Dizziness (11%) Dry mouth (4%) Dyskinesia (6%) Hallucinations (4%) Headache (7%) Insomnia (7%) Somnolence (3%) Tremor (3%) Dyspnea (3%) Pharyngitis (4%) Rhinitis (7%) Rash (4%) Skin disorder (6%) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021479s003s004lbl.pdf

AEs

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1709	substrate 1010	substrate 1193

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP2A6 704 CYP2B6 799 UGT2B10 25	P-gp 1527 CYP1A1 348 CYP1A2 1032 CYP2A6 523 CYP2B6 660 CYP2C8 688 CYP2C19 985 CYP2E1 648

Drug as perpetrator

Target	Modality	Activity
UGT2B10 27	inhibitor 3240 Sources: https://pubmed.ncbi.nlm.nih.gov/26669329/	yes [IC50 67.2 uM]
CYP2A6 736	inhibitor 3240 Sources: https://pubmed.ncbi.nlm.nih.gov/18065502/	yes [Ki 15.6 uM]
CYP2B6 985	inhibitor 3240 Sources: https://pubmed.ncbi.nlm.nih.gov/25656918/	yes [Ki 22 uM]

Drug as victim

Target	Modality	Activity
CYP2B6 660	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/ \| https://pubmed.ncbi.nlm.nih.gov/12920164/ \| https://pubmed.ncbi.nlm.nih.gov/17495414/ \| https://pubmed.ncbi.nlm.nih.gov/15618670/	major
CYP2C19 985	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/ \| https://pubmed.ncbi.nlm.nih.gov/12920164/ \| https://pubmed.ncbi.nlm.nih.gov/10862503/ \| https://pubmed.ncbi.nlm.nih.gov/15618670/	major
CYP1A2 1032	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/ \| https://pubmed.ncbi.nlm.nih.gov/12920164/ \| https://pubmed.ncbi.nlm.nih.gov/10862503/ \| https://pubmed.ncbi.nlm.nih.gov/15618670/	minor
CYP3A4 1709	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/ \| https://pubmed.ncbi.nlm.nih.gov/10862503/ \| https://pubmed.ncbi.nlm.nih.gov/17495414/ \| https://pubmed.ncbi.nlm.nih.gov/15618670/	minor
CYP1A1 348	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/	no
CYP2A6 523	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/	no
CYP2C9 1010	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/	no
CYP2D6 1193	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/	no
CYP2E1 648	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/	no
P-gp 1527	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/12438524/	no
CYP2C8 688	substrate 3326 Sources: https://pubmed.ncbi.nlm.nih.gov/11602525/ \| https://pubmed.ncbi.nlm.nih.gov/12920164/	yes

PubMed

Title	Date	PubMed
Pharmacological options for the treatment of Tourette's disorder.	2001	11772131
The effect of low oral doses of (-)-deprenyl and its metabolites on DSP-4 toxicity.	2001	11768624
[The effect of selegiline and vitamin E in the treatment of ALS: an open randomized clinical trials].	2001	11732275
Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline.	2001	11716151
Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment.	2001	11599635
Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy.	2001 Apr	11795516
Deprenyl stimulates the efflux of monoamines from the rat hypothalamus in vitro.	2001 Apr	11403995
Evaluation of antiparkinsonian drugs in pharmacy records as a marker for Parkinson's disease.	2001 Aug	11599201
[Parkinson's disease].	2001 Aug	11519161
Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.	2001 Aug	11454735
Investigating potential anxiolytic, antidepressant and memory enhancing activity of deprenyl.	2001 Dec	11785779
Zonisamide has beneficial effects on Parkinson's disease patients.	2001 Dec	11755227
Antiaging compounds: (-)deprenyl (selegeline) and (-)1-(benzofuran-2-yl)-2-propylaminopentane, [(-)BPAP], a selective highly potent enhancer of the impulse propagation mediated release of catecholamine and serotonin in the brain.	2001 Fall	11607046
Biphasic effects of selegiline on striatal dopamine: lack of effect on methamphetamine-induced dopamine depletion.	2001 Jan	11358284
Current advances in Parkinson's disease.	2001 Jul	11467283
Selegiline and mortality in subjects with Parkinson's disease: a longitudinal community study.	2001 Jul 24	11480425
Selegiline and mortality in subjects with Parkinson's disease: a longitudinal community study.	2001 Jul 24	11468339
Rescue of dying neurons by (R)-deprenyl in the MPTP-mouse model of Parkinson's disease does not include restoration of neostriatal dopamine.	2001 Jun	11462789
Inhibition of MAO-A activity enhances behavioural activity of rats assessed using water maze and open arena tasks.	2001 Jun	11453370
The frissonnant mutant mouse, a model of dopamino-sensitive, inherited motor syndrome.	2001 Jun	11442353
PET with 11C-deuterium-deprenyl and 18F-FDG in focal epilepsy.	2001 Jun	11421848
Advances in managing Parkinson's disease.	2001 Jun 15	11419534
Practice parameters for the treatment of narcolepsy: an update for 2000.	2001 Jun 15	11403530
Freezing of gait in PD: prospective assessment in the DATATOP cohort.	2001 Jun 26	11425939
Eldepryl prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nigral neuronal apoptosis in mice.	2001 Mar	11780305
Parkinson's disease therapy: treatment of early and late disease.	2001 Mar	11780303
Current and emerging treatments in Parkinson's disease.	2001 Mar	11379409
[A behavioral and neurochemical study on the mechanism of the anxiolytic effect of monoamine oxidase inhibitors].	2001 May	11481866
CYP2C19 polymorphism is not important for the in vivo metabolism of selegiline.	2001 May	11417445
[Parkinson patients. Normal life expectancy with selegiline?].	2001 May 28	11434273
Evidence that L-deprenyl treatment for one week does not inhibit MAO A or the dopamine transporter in the human brain.	2001 May 4	11400918
The effects of oral selegiline hydrochloride on learning and training in the dog: a psychobiological interpretation.	2001 Nov	11642657
CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes.	2001 Nov	11602525
Ten-year follow-up of three different initial treatments in de-novo PD: a randomized trial.	2001 Nov 13	11706112
(-)-D-Deprenyl attenuates apoptosis in experimental brain ischaemia.	2001 Nov 2	11711036
Chronic daily administration of selegiline and EGb 761 increases brain's resistance to ischemia in mice.	2001 Nov 2	11640903
Switching from bromocriptine to ropinirole in patients with advanced Parkinson's disease: open label pilot responses to three different dose-ratios.	2001 Nov-Dec	11801810
Incorporation of selegiline metabolites into hair after oral selegiline intake.	2001 Oct	11599606
Future of neuroprotection in Parkinson's disease.	2001 Oct	11489679
Drug-induced psychotic symptoms in Parkinson's disease. Problems, management and dilemma.	2001 Sep	11697685
Toxicokinetics of amphetamines: metabolism and toxicokinetic data of designer drugs, amphetamine, methamphetamine, and their N-alkyl derivatives.	2002 Apr	11897973
Antiapoptotic effect of (-)-deprenyl in rat kidney after ischemia-reperfusion.	2002 Feb	11859269
The effect of selegiline in the treatment of people with Alzheimer's disease: a meta-analysis of published trials.	2002 Feb	11813282
Neuroprotective actions of selegiline.	2002 Feb 1	11813232
Neuroprotective and neurotoxic effects of monoamine oxidase-B inhibitors and derived metabolites under ischemia in PC12 cells.	2002 Jan 11	11779573
Deprenyl protects from MPTP-induced Parkinson-like syndrome and glutathione oxidation in rat striatum.	2002 Jan 25	11788154
Practice parameter: initiation of treatment for Parkinson's disease: an evidence-based review: report of the Quality Standards Subcommittee of the American Academy of Neurology.	2002 Jan 8	11781398
Treatment of periodic limb movements in sleep with selegiline HCl.	2002 Mar	11921131
Placebo-associated improvements in motor function: comparison of subjective and objective sections of the UPDRS in early Parkinson's disease.	2002 Mar	11921113
Inhibition of human LDL oxidation by the neuroprotective drug l-deprenyl.	2002 Mar	11877901

Patents

Sample Use Guides

In Vivo Use Guide

Usual Adult Dose for Parkinson's Disease: Recommended dose: 5 mg orally twice a day, Maximum dose: 10 mg orally per day Usual Adult Dose for Depression: Initial dose: Apply one 6 mg/24 hours transdermal patch to intact skin once every 24 hours, Maintenance dose: One 6 mg/24 hours to 12 mg/24 hours transdermal patch applied to the skin once a day, Maximum dose: 12 mg/24 hours transdermal patch applied to the skin once a day

Route of Administration: Other

In Vitro Use Guide

BEAS-2B cells were seeded in 6 cm dishes. Cells were pretreated with 100 nM selegiline for 30 min before further exposed to 2% CSM for 24 h. Total protein was extracted. Monoamine Oxidase Activity Fluorometric Assay Kit (BioVision Inc., Milpitas, CA, USA), Superoxide Dismutase (SOD) Detection kit (Nanjing Jiancheng Bioenginering Inst., China), Amplex Red Catalase Assay kit (Molecular Probes, Inc., Eugene, OR, USA) and Oxidative Glutathi-one (GSSG) Detection Kit (Nanjing Jiancheng Bioenginering Y. Cui et al. / Toxicology Letters 268 (2017) 44–50 45Inst., China) were used for MAO, SOD and CAT activities and GSH/GSSG ratio measurement, respectively.

Substance Class	Chemical Created by `admin` on `Wed Jul 05 22:48:31 UTC 2023` Edited by `admin` on `Wed Jul 05 22:48:31 UTC 2023`
Record UNII	6W731X367Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SELEGILINE HYDROCHLORIDE

Official Name

English

Selegiline hydrochloride [WHO-DD]

Common Name

English

SELEGILINE HYDROCHLORIDE [MI]

Common Name

English

(-)-(R)-N,.ALPHA.-DIMETHYL-N-2-PROPYNYLPHENETHYLAMINE HYDROCHLORIDE

Systematic Name

English

SELEGILINE HYDROCHLORIDE [JAN]

Common Name

English

SELEGILINE HYDROCHLORIDE [USAN]

Common Name

English

L-DEPRENYL

Common Name

English

SELEGILINE HYDROCHLORIDE [USP MONOGRAPH]

Common Name

English

SELEGILINE HCL

Common Name

English

ZELAPAR

Brand Name

English

BENZENEETHANAMINE, N,.ALPHA.-DIMETHYL-N-2-PROPYNYL-, HYDROCHLORIDE, (R)-

Systematic Name

English

ELDEPRYL

Brand Name

English

NSC-759259

Code

English

SELEGILINE HYDROCHLORIDE [GREEN BOOK]

Common Name

English

SELEGILINE HYDROCHLORIDE [HSDB]

Common Name

English

SELEGILINE HYDROCHLORIDE [VANDF]

Common Name

English

SELEGILINE HYDROCHLORIDE [EP MONOGRAPH]

Common Name

English

SELEGILINE HYDROCHLORIDE [ORANGE BOOK]

Common Name

English

SELEGILINE HYDROCHLORIDE [USP-RS]

Common Name

English

SELEGILINE HYDROCHLORIDE [MART.]

Common Name

English

ENSAM

Brand Name

English

Classification Tree Code System Code

NCI_THESAURUS

C667