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Details

Stereochemistry ACHIRAL
Molecular Formula 2C2H4NO2.Cu
Molecular Weight 211.663
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CUPRIC GLYCINATE

SMILES

[Cu++].NCC([O-])=O.NCC([O-])=O

InChI

InChIKey=VVYPIVJZLVJPGU-UHFFFAOYSA-L
InChI=1S/2C2H5NO2.Cu/c2*3-1-2(4)5;/h2*1,3H2,(H,4,5);/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula C2H4NO2
Molecular Weight 74.0587
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Cu
Molecular Weight 63.546
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Sources: http://fs1.agrian.com/pdfs/CORE_7.5_Copper_EDTA_Label.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/24106015 | https://www.ncbi.nlm.nih.gov/pubmed/20942456http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500013010.pdfhttp://www.drugfuture.com/chemdata/tetraamminecopper-sulfate.html | https://cameochemicals.noaa.gov/chemical/3026https://www.ncbi.nlm.nih.gov/pubmed/6526221https://www.ncbi.nlm.nih.gov/pubmed/16971307https://www3.epa.gov/pesticides/chem_search/ppls/019713-00509-20110705.pdfhttps://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=522.518 | http://www.worldofchemicals.com/chemicals/chemical-properties/cupric-glycinate.htmlDOI: 10.1107/s0567740869001725 Retrived from http://scripts.iucr.org/cgi-bin/paper?S0567740869001725https://www.ncbi.nlm.nih.gov/pubmed/15704330 | https://www.ncbi.nlm.nih.gov/pubmed/12425037 | https://www.ncbi.nlm.nih.gov/pubmed/1599240 | http://www.certisusa.com/pdf-labels/Kocide3000_label.pdf | http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33524https://www.ncbi.nlm.nih.gov/pubmed/8556785 | https://www.ncbi.nlm.nih.gov/pubmed/2135524http://www.emdmillipore.com/US/en/product/Copper-di-ammonium-Titriplex-solution,MDA_CHEM-105217https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a84d61a4-8e7f-4be1-aba6-f633b334aafc | http://www.sciencedirect.com/science/article/pii/S0167488912000158http://www.drugfuture.com/chemdata/schweizer-s-reagent.html | http://pubs.acs.org/doi/abs/10.1021/ed062p878?journalCode=jceda8 | http://pubs.acs.org/doi/abs/10.1021/ed019p356
Curator's Comment: description was created based on several sources, including: https://brandt.co/media/3786/09006mnr100_mineral-research_copper-count-n_lbl_2012-12_25g.pdf | https://southernag.com/wp-content/uploads/2014/06/southernag.com_docs_labels_msds_Liq-Copper-Gal.pdf

Tetraamminecopper dihydroxide also known as Schweizer's Reagent dissolves cellulose; used in rayon production.

CNS Activity

Curator's Comment: Cupric ion was shown to cross the blood brain barrier in rats.

Originator

Sources: http://pubs.acs.org/doi/abs/10.1021/ja01512a012Schweizer, J. Prakt. Chem. 72, 109, 344 (1857).
Curator's Comment: http://www.drugfuture.com/chemdata/schweizer-s-reagent.html

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
3.42 µM [Ki]
Target ID: P00450
Gene ID: 1356.0
Gene Symbol: CP
Target Organism: Homo sapiens (Human)
Target ID: Glutathione S-transferase, rat, liver
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Preventing
Cupric glycinate

Approved Use

Indications for use. For beef calves and beef cattle for the prevention of copper deficiency, or when labeled for veterinary prescription use, for the prevention and/or treatment of copper deficiency alone or in association with molybdenum toxicity.
Primary
COPPER•MAX

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Diagnostic
Unknown

Approved Use

Unknown
Preventing
COPPER

Approved Use

Copper 0.4 mg/mL (Cupric Chloride Injection, USP) is indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN). Administration helps to maintain copper serum levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Preventing
COPINOX

Approved Use

Copinox 4g is indicated for the prevention and treatment of copper deficiency in cattle and sheep.
PubMed

PubMed

TitleDatePubMed
The effectiveness of ecologically acceptable ways of protection of field-grown tomato (Lycopersicon lycopersicum (L.) Karsten) from tomato late blight (Phytophthora infestans (Mont.) de Bary) in extreme weather conditions.
2001
Antioxidant activity of olive pulp and olive oil phenolic compounds of the arbequina cultivar.
2005 Mar 23
A spectroscopic and thermoanalytical study of the mineral hoganite.
2007 May
Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide.
2008 Nov 1
Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes.
2009 Jan 16
Expeditious synthesis of phenanthrenes via CuBr2-catalyzed coupling of terminal alkynes and N-tosylhydrazones derived from o-formyl biphenyls.
2011 Oct 7
Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3.
2012 Feb
Cytotoxicity in the age of nano: the role of fourth period transition metal oxide nanoparticle physicochemical properties.
2013 Nov 25
Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions.
2014
Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells.
2014 Jul
Electron induced surface reactions of organometallic metal(hfac)₂ precursors and deposit purification.
2014 Jun 11
Ultrasonic energy enhanced the efficiency of advance extraction methodology for enrichment of trace level of copper in serum samples of patients having neurological disorders.
2017 Jul
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Veterinary drug
Administer ONLY by subcutaneous (under the skin) injection. These doses may be repeated at a minimum period of every 4 months. Dosage may be increased to 4mL in cattle only when either clinical signs or laboratory testing has confirmed copper deficiency is severe. Cattle over 4 months 2mL (0.5 mg calcium copper edetate) Adult Sheep 1mL (0.25 mg calcium copper edetate) Deer 1mL (0.25 mg calcium copper edetate) per 50kg bodyweight
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Wed Jul 05 22:48:09 UTC 2023
Edited
by admin
on Wed Jul 05 22:48:09 UTC 2023
Record UNII
68VAV8QID7
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CUPRIC GLYCINATE
GREEN BOOK  
Common Name English
COPPER(II) GLYCINATE
Systematic Name English
BIS(GLYCINATO-N,O)COPPER
Common Name English
Copper glycinate [WHO-DD]
Common Name English
CUPRIC BISGLYCINATE
MI  
Common Name English
CUPRIC BISGLYCINATE [MI]
Common Name English
COPPER GLYCINATE [INCI]
Common Name English
COPPER GLYCINATE
INCI   WHO-DD  
INCI  
Official Name English
CUPRIC GLYCINATE [GREEN BOOK]
Common Name English
NSC-162736
Code English
COPPER(II) BISGLYCINATE
Systematic Name English
Classification Tree Code System Code
CFR 21 CFR 522.518
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
NCI_THESAURUS C802
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
Code System Code Type Description
WIKIPEDIA
Copper(II) glycinate
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
CAS
32817-15-5
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
ALTERNATIVE
CAS
5789-40-2
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
SUPERSEDED
EVMPD
SUB13502MIG
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
SMS_ID
100000079503
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
RXCUI
1428217
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY RxNorm
CAS
13479-54-4
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
NSC
162736
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
EPA CompTox
DTXSID40893690
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
DAILYMED
68VAV8QID7
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
DRUG BANK
DB11509
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
ECHA (EC/EINECS)
236-783-2
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
PUBCHEM
3032611
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
NCI_THESAURUS
C83639
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
ECHA (EC/EINECS)
251-238-9
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
ALTERNATIVE
MERCK INDEX
M3887
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY Merck Index
CAS
142-51-8
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
SUPERSEDED
FDA UNII
68VAV8QID7
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
MESH
C018493
Created by admin on Wed Jul 05 22:48:09 UTC 2023 , Edited by admin on Wed Jul 05 22:48:09 UTC 2023
PRIMARY
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