ECLANAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H22Cl2N2O
Molecular Weight	329.265
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC(=O)N([C@@H]1CCC[C@H]1N(C)C)C2=CC=C(Cl)C(Cl)=C2

InChI

InChIKey=YCRFSKUCDBJWLX-HUUCEWRRSA-N

InChI=1S/C16H22Cl2N2O/c1-4-16(21)20(11-8-9-12(17)13(18)10-11)15-7-5-6-14(15)19(2)3/h8-10,14-15H,4-7H2,1-3H3/t14-,15-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C16H22Cl2N2O
Molecular Weight	329.265
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7328583 | https://www.ncbi.nlm.nih.gov/pubmed/2851860 | https://books.google.ru/books?id=0vXTBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false

Eclanamine is a nontricyclic antidepressant agent. Down-regulation of beta-adrenergic receptors in the cerebral cortex may be involved in mediating the eclanamine pharmacological effect.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds.	1981 Oct	7328583
Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants.	1988	2851860

Sample Use Guides

In Vivo Use Guide

female Sprague-Dawley rats: 1, 3, 10, and 30 mg/kg/day

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:59:09 GMT 2025` Edited by `admin` on `Mon Mar 31 17:59:09 GMT 2025`
Record UNII	5Y67H9W4KQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ECLANAMINE

Official Name

English

U-48753E

Preferred Name

English

eclanamine [INN]

Common Name

English

(±)-TRANS-3',4'-DICHLORO-N-(2-(DIMETHYLAMINO)CYCLOPENTYL)PROPIONANILIDE

Systematic Name

English

PROPANAMIDE, N-(3,4-DICHLOROPHENYL)-N-(2-(DIMETHYLAMINO)CYCLOPENTYL)-, TRANS-(±)-

Common Name

English

Classification Tree Code System Code

CDC

U-48753E