ECLANAMINE MALEATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H22Cl2N2O.C4H4O4
Molecular Weight	445.337
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.CCC(=O)N([C@@H]1CCC[C@H]1N(C)C)C2=CC(Cl)=C(Cl)C=C2

InChI

InChIKey=ZEUQHGFLDLNEOB-CHHFXETESA-N

InChI=1S/C16H22Cl2N2O.C4H4O4/c1-4-16(21)20(11-8-9-12(17)13(18)10-11)15-7-5-6-14(15)19(2)3;5-3(6)1-2-4(7)8/h8-10,14-15H,4-7H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C16H22Cl2N2O
Molecular Weight	329.265
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7328583 | https://www.ncbi.nlm.nih.gov/pubmed/2851860 | https://books.google.ru/books?id=0vXTBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false

Eclanamine is a nontricyclic antidepressant agent. Down-regulation of beta-adrenergic receptors in the cerebral cortex may be involved in mediating the eclanamine pharmacological effect.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorophenyl)propanamide and related compounds.	1981 Oct	7328583
Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants.	1988	2851860

Sample Use Guides

In Vivo Use Guide

female Sprague-Dawley rats: 1, 3, 10, and 30 mg/kg/day

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:35:59 UTC 2023` Edited by `admin` on `Fri Dec 15 17:35:59 UTC 2023`
Record UNII	J2C169J769
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ECLANAMINE MALEATE

Official Name

English

U-48753E

Code

English

U-48,753E

Code

English

ECLANAMINE MALEATE [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265