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Details

Stereochemistry ACHIRAL
Molecular Formula C17H23NO4
Molecular Weight 305.3688
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CETRAXATE

SMILES

NC[C@H]1CC[C@@H](CC1)C(=O)OC2=CC=C(CCC(O)=O)C=C2

InChI

InChIKey=FHRSHSOEWXUORL-HDJSIYSDSA-N
InChI=1S/C17H23NO4/c18-11-13-1-6-14(7-2-13)17(21)22-15-8-3-12(4-9-15)5-10-16(19)20/h3-4,8-9,13-14H,1-2,5-7,10-11,18H2,(H,19,20)/t13-,14-

HIDE SMILES / InChI

Molecular Formula C17H23NO4
Molecular Weight 305.3688
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Cetraxate is an oral gastrointestinal medication, mucosal protectant. Cetraxate might indirectly stimulate capsaicin-sensitive afferent nerves and increase mucosal blood flow, and that this may be a key mechanism underlying its gastroprotective action. Cetraxate prevents gastric mucosal blood flow decrease in H. pylori-infected patients. It is usually used to improve gastric mucosal lesion in acute gastritis or acute exacerbation of chronic gastritis and to treat gastric ulcer. The most commonly reported adverse reactions include constipation, rash, nausea, vomiting, dry mouth and diarrhea.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Neuer
Primary
Neuer

PubMed

Sample Use Guides

In Vivo Use Guide
200 mg 3-4 times per day
Route of Administration: Oral
In Vitro Use Guide
The amounts of Cetraxate to prolong the recalcification time of citrated plasma to 2 times were approximately 50 ug in the ordinary glass tube and 25 ug in the siliconized tube.
Substance Class Chemical
Record UNII
5VPA8CPF0N
Record Status Validated (UNII)
Record Version