Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C17H23NO4.ClH |
| Molecular Weight | 341.83 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.NC[C@H]1CC[C@@H](CC1)C(=O)OC2=CC=C(CCC(O)=O)C=C2
InChI
InChIKey=USROQQUKEBHOFF-SKKCDYJJSA-N
InChI=1S/C17H23NO4.ClH/c18-11-13-1-6-14(7-2-13)17(21)22-15-8-3-12(4-9-15)5-10-16(19)20;/h3-4,8-9,13-14H,1-2,5-7,10-11,18H2,(H,19,20);1H/t13-,14-;
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C17H23NO4 |
| Molecular Weight | 305.3688 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including:
http://www.229877.com/article/2016/0303/article_36173.html | https://www.ncbi.nlm.nih.gov/pubmed/4261023
Curator's Comment: description was created based on several sources, including:
http://www.229877.com/article/2016/0303/article_36173.html | https://www.ncbi.nlm.nih.gov/pubmed/4261023
Cetraxate is an oral gastrointestinal medication, mucosal protectant. Cetraxate might indirectly stimulate capsaicin-sensitive afferent nerves and increase mucosal blood flow, and that this may be a key mechanism underlying its gastroprotective action. Cetraxate prevents gastric mucosal blood flow decrease in H. pylori-infected patients. It is usually used to improve gastric mucosal lesion in acute gastritis or acute exacerbation of chronic gastritis and to treat gastric ulcer. The most commonly reported adverse reactions include constipation, rash, nausea, vomiting, dry mouth and diarrhea.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2095204 |
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Target ID: UDP-galactosyltransferase (rat) |
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Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Neuer Approved UseIt is usually used to improve gastric mucosal lesion in acute gastritis or acute exacerbation of chronic gastritis and to treat gastric ulcer. |
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| Primary | Neuer Approved UseIt is usually used to improve gastric mucosal lesion in acute gastritis or acute exacerbation of chronic gastritis and to treat gastric ulcer. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Influence of Helicobacter pylori infection and cetraxate on gastric mucosal blood flow during healing of endoscopic mucosal resection-induced ulcers. | 2001 Nov |
|
| Purification and characterization of a novel esterase promising for the production of useful compounds from Microbacterium sp. 7-1W. | 2002 Jan 10 |
|
| Enzymatic preparation of D-beta-acetylthioisobutyric acid and cetraxate hydrochloride using a stereo- and/or regioselective hydrolase, 3,4-dihydrocoumarin hydrolase from Acinetobacter calcoaceticus. | 2002 Nov |
|
| Biocatalytic deprotection of a cetraxate ester by Microbacterium sp. strain 7-1W cells. | 2003 Jan |
|
| Comparison of cetraxate-based and pantoprazole-based triple therapies in the treatment of Helicobacter pylori infection. | 2004 Apr |
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| Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma. | 2004 Apr |
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| DA-9601 for erosive gastritis: results of a double-blind placebo-controlled phase III clinical trial. | 2004 Aug 15 |
|
| Efficacy of triple therapy plus cetraxate for the Helicobacter pylori eradication in partial gastrectomy patients. | 2005 May |
|
| [Eradication therapy for the remnant stomach infected with Helicobacter pylori ]. | 2005 Nov |
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| [Cetraxate hydrochloride (Neuer) induces the effectiveness of new triple therapy in H. pylori eradication]. | 2005 Nov |
|
| Comparison of the effects of cytoprotective drugs on human plasma adrenocorticotropic hormone and cortisol levels with continual stress exposure. | 2005 Nov |
|
| 15th anniversary of rebamipide: looking ahead to the new mechanisms and new applications. | 2005 Oct |
|
| Are gastroprotective drugs useful for gastric ulcer healing: re-evaluation using current ICH E9 guidelines. | 2007 Feb |
|
| [Side effects of gastric muco-protective agents]. | 2007 Oct 28 |
|
| Gastroduodenal mucosal injury in patients taking low-dose aspirin and the role of gastric mucoprotective drugs: possible effect of rebamipide. | 2010 Jul |
|
| Rebamipide: a gastrointestinal protective drug with pleiotropic activities. | 2010 Jun |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:07:26 GMT 2023
by
admin
on
Fri Dec 15 15:07:26 GMT 2023
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| Record UNII |
08IT6P8VHY
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C28197
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C84661
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27724-96-5
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DTXSID3046459
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m3293
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100000084687
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08IT6P8VHY
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SUB01172MIG
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CHEMBL1187445
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T-84
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |