Details
Stereochemistry | ACHIRAL |
Molecular Formula | C2HCl3O2 |
Molecular Weight | 163.387 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C(Cl)(Cl)Cl
InChI
InChIKey=YNJBWRMUSHSURL-UHFFFAOYSA-N
InChI=1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
Molecular Formula | C2HCl3O2 |
Molecular Weight | 163.387 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Trichloroacetic acid (TCA; TCAA) is a chemical used in skin peel formulations. It is more frequently used for lighter skin and is less used on darker skin because of the higher risks of scarring, as well as post-peel dyschromias. Low concentrations, 10-35% is preferred for skin peel formulations so that it only reaches the upper papillary dermis. Topical TCA is an efficacious treatment of internal anal high-grade squamous intraepithelial lesions (HSIL). Advantages of TCA for this recurrent disease process include low cost, no requirement for special equipment beyond that for high-resolution anoscopy, and painless application procedure.
Approval Year
PubMed
Title | Date | PubMed |
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Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses. | 2001 |
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Fifty years of dysentery research at the Pécs University. | 2001 |
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The [15N]methacetin liver function test characterizes multicomponent exposure of children in industrially polluted regions. | 2001 |
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Exogenous ochronosis. An update on clinical features, causative agents and treatment options. | 2001 |
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Synthesis of disaccharides related to the mycobacterial arabinogalactan. | 2001 |
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A multi media load model for the Baltic Sea. | 2001 |
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Site-specific mutations of FtsZ--effects on GTPase and in vitro assembly. | 2001 |
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Deproteinization of serum: another best approach to eliminate all forms of bilirubin interference on serum creatinine by the kinetic Jaffe reaction. | 2001 |
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Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone. | 2001 |
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The effects of alpha-lactabumin and whey protein concentrate on dry matter recovery, TCA soluble protein levels, and peptide distribution in the rat gastrointestinal tract. | 2001 Apr |
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Trimethylamine and total volatile basic nitrogen determination by flow injection/gas diffusion in Mediterranean hake (Merluccius merluccius). | 2001 Apr |
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Haloacetates in fog and rain. | 2001 Apr 1 |
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Effect of the eluent pH and acidic modifiers in high-performance liquid chromatography retention of basic analytes. | 2001 Apr 13 |
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Effects of the matrix and sample preparation on the determination of fluoroquinolone residues in animal tissues. | 2001 Apr 20 |
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Sample preparation for residue determination of gentamicin and neomycin by liquid chromatography. | 2001 Apr 20 |
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High-performance liquid chromatographic determination of cefepime in human plasma and in urine and dialysis fluid using a column-switching technique. | 2001 Apr 25 |
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Molluscum contagiosum in herpes zoster scars. | 2001 Aug |
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Photosonochemical degradation of trichloroacetic acid in aqueous solution. | 2001 Aug |
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Stability of a cisplatin-chondroitin sulfate A complex in plasma and kidney in terms of protein binding. | 2001 Aug |
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Factors involved in clearance of genital warts. | 2001 Dec |
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Diagnosis and management of cervical intraepithelial neoplasia. | 2001 Dec |
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Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway. | 2001 Dec |
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Application of quantitative ethanol detector (QED) test kit to measure ethanol concentration in blood samples. | 2001 Dec 27 |
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Feasibility of iodine-125 labeled anti-human hemoglobin antibody in the detection of bleeding sites from the large bowel-A preliminary study. | 2001 Jul |
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Medium-depth chemical peels. | 2001 Jul |
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A new glycogen synthase activity ratio in skeletal muscle: effects of exercise and insulin. | 2001 Jul 13 |
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Isolation and specific detection of two major schistosoma gut-associated circulating antigens. | 2001 Jun |
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Reduction of haloacetic acids by Fe0: implications for treatment and fate. | 2001 Jun 1 |
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Direct electrochemistry of hemoglobin in layer-by-layer films with poly(vinyl sulfonate) grown on pyrolytic graphite electrodes. | 2001 Mar |
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The treatment of eruptive syringomas in an African American patient with a combination of trichloroacetic acid and CO2 laser destruction. | 2001 May |
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How Ala-->Gly mutations in different helices affect the stability of the apomyoglobin molten globule. | 2001 May 1 |
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Tethered dithiacyclopropenones. syntheses and structural properties of tetrathiacyclopropenonophanes. | 2001 May 18 |
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A facile and effective synthesis of alpha-(1-->6)-linked mannose di-, tri-, tetra-, hexa-, octa-, and dodecasaccharides, and beta-(1-->6)-linked glucose di-, tri-, tetra-, hexa-, and octasaccharides using sugar trichloroacetimidates as the donors and unprotected or partially protected glycosides as the acceptors. | 2001 May 8 |
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Outcome of 22 cases of perforated tympanic membrane caused by otomycosis. | 2001 Nov |
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Differences in yields of microbial crude protein from in vitro fermentation of carbohydrates. | 2001 Nov |
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Improved radioiodination of biomolecules using exhaustive Chloramine-T oxidation. | 2001 Nov |
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Antibodies against Streptococcus agalactiae proteins c(alpha) and R4 in sera from pregnant women from Norway and Zimbabwe. | 2001 Nov |
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Antiparallel pleated beta-sheets observed in crystal structures of N,N-bis(trichloroacetyl) and N,N-bis(m-bromobenzoyl) gramicidin S. | 2001 Nov 1 |
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Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation. | 2001 Nov 6 |
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An immunohistological study of the localization characteristics of thymus and activation-regulated chemokine in the allergic inferior turbinate mucosa with reference to the effectiveness of trichloroacetic acid treatment. | 2001 Nov-Dec |
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New method for exopolysaccharide determination in culture broth using stirred ultrafiltration cells. | 2001 Oct |
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The application of physiologically based pharmacokinetic modelling in the analysis of occupational exposure to perchloroethylene. | 2001 Oct 15 |
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Estimating internal phosphorus pools in macroalgae using radioactive phosphorus and trichloroacetic acid extracts. | 2001 Oct 15 |
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Trace determination of 1-octacosanol in rat plasma by solid-phase extraction with Tenax GC and capillary gas chromatography. | 2001 Oct 5 |
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Synthesis of a set of di- and tri-sulfated galabioses. | 2001 Oct 8 |
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Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect fetal rat heart development? | 2001 Sep-Oct |
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The immunosuppressive activity of chemically modified lipopolysaccharide of Shigella sonnei. | 2002 Jan 1 |
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Sources, pathways, and relative risks of contaminants in surface water and groundwater: a perspective prepared for the Walkerton inquiry. | 2002 Jan 11 |
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Study of competitive binding of enantiomers to protein by affinity capillary electrochromatography. | 2002 Jan 15 |
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Succinate dehydrogenase and fumarate reductase from Escherichia coli. | 2002 Jan 17 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23130283
Curator's Comment: http://www.ncbi.nlm.nih.gov/pubmed/24922100
for melasma: 15% TCA peel
for anal high-grade squamous intraepithelial lesions: 80% TCA
Route of Administration:
Topical
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/23812791
Lymphocytes obtained from three healthy donors were exposed to 25, 50, and 100 μg/ml concentration of TCA separately. TCA exposure resulted in chromosomal anomalies and the formation of micronuclei in lymphocytes. Chromosome analysis revealed the dose-dependent and significant induction of Chromosomal aberration (CA).
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:03:06 GMT 2023
by
admin
on
Fri Dec 15 15:03:06 GMT 2023
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Record UNII |
5V2JDO056X
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
81002
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IARC | Trichloroacetic acid |
Code System | Code | Type | Description | ||
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100000077252
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10773
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m11062
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PRIMARY | Merck Index | ||
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TCA
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5V2JDO056X
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D014238
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5V2JDO056X
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6421
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TRICHLOROACETIC ACID
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DTXSID1021378
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618564
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ALTERNATIVE | |||
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CHEMBL14053
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SUB15604MIG
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27455
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215204
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30956
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76-03-9
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DB11152
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3627
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Trichloroacetic Acid
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200-927-2
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1779
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT | |||
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SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
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PARENT -> METABOLITE INACTIVE |
MAJOR
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Related Record | Type | Details | ||
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ACTIVE MOIETY |