Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2Cl3O2.Na |
| Molecular Weight | 185.369 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[O-]C(=O)C(Cl)(Cl)Cl
InChI
InChIKey=SAQSTQBVENFSKT-UHFFFAOYSA-M
InChI=1S/C2HCl3O2.Na/c3-2(4,5)1(6)7;/h(H,6,7);/q;+1/p-1
| Molecular Formula | C2Cl3O2 |
| Molecular Weight | 162.379 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Trichloroacetic acid (TCA; TCAA) is a chemical used in skin peel formulations. It is more frequently used for lighter skin and is less used on darker skin because of the higher risks of scarring, as well as post-peel dyschromias. Low concentrations, 10-35% is preferred for skin peel formulations so that it only reaches the upper papillary dermis. Topical TCA is an efficacious treatment of internal anal high-grade squamous intraepithelial lesions (HSIL). Advantages of TCA for this recurrent disease process include low cost, no requirement for special equipment beyond that for high-resolution anoscopy, and painless application procedure.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses. | 2001 |
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| Fifty years of dysentery research at the Pécs University. | 2001 |
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| The [15N]methacetin liver function test characterizes multicomponent exposure of children in industrially polluted regions. | 2001 |
|
| Exogenous ochronosis. An update on clinical features, causative agents and treatment options. | 2001 |
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| Small-scale analysis of exopolysaccharides from Streptococcus thermophilus grown in a semi-defined medium. | 2001 |
|
| Synthesis of disaccharides related to the mycobacterial arabinogalactan. | 2001 |
|
| A multi media load model for the Baltic Sea. | 2001 |
|
| Molluscum contagiosum in herpes zoster scars. | 2001 Aug |
|
| [Endogenic intoxication markers: data from capillary electrophoresis of trichloroacetic acid supernatant]. | 2001 Aug |
|
| New formulation of chemical peeling agent: histological evaluation in sun-damaged skin model in hairless mice. | 2001 Aug |
|
| Photosonochemical degradation of trichloroacetic acid in aqueous solution. | 2001 Aug |
|
| Stability of a cisplatin-chondroitin sulfate A complex in plasma and kidney in terms of protein binding. | 2001 Aug |
|
| Kinetics in the pre-steady state of the formation of cystines in ribonucleoside diphosphate reductase: evidence for an asymmetric complex. | 2001 Aug 14 |
|
| Assay of 2,3-dihydroxybenzoic acid and related compounds in plant materials by high-performance liquid chromatography. | 2001 Aug 24 |
|
| Factors involved in clearance of genital warts. | 2001 Dec |
|
| Diagnosis and management of cervical intraepithelial neoplasia. | 2001 Dec |
|
| Trichloroethylene oxidative metabolism in plants: the trichloroethanol pathway. | 2001 Dec |
|
| Application of quantitative ethanol detector (QED) test kit to measure ethanol concentration in blood samples. | 2001 Dec 27 |
|
| Feasibility of iodine-125 labeled anti-human hemoglobin antibody in the detection of bleeding sites from the large bowel-A preliminary study. | 2001 Jul |
|
| Medium-depth chemical peels. | 2001 Jul |
|
| Dermal peels. | 2001 Jul |
|
| A simple HPLC method for the determination of the mycotoxins ochratoxin A and B in blood serum of swine. | 2001 Jul |
|
| A new glycogen synthase activity ratio in skeletal muscle: effects of exercise and insulin. | 2001 Jul 13 |
|
| Sensitive and simple determination of mannitol in human brain tissues by gas chromatography-mass spectrometry. | 2001 Jul 5 |
|
| Isolation and specific detection of two major schistosoma gut-associated circulating antigens. | 2001 Jun |
|
| Outcome of 22 cases of perforated tympanic membrane caused by otomycosis. | 2001 Nov |
|
| Differences in yields of microbial crude protein from in vitro fermentation of carbohydrates. | 2001 Nov |
|
| Improved radioiodination of biomolecules using exhaustive Chloramine-T oxidation. | 2001 Nov |
|
| Antibodies against Streptococcus agalactiae proteins c(alpha) and R4 in sera from pregnant women from Norway and Zimbabwe. | 2001 Nov |
|
| Antiparallel pleated beta-sheets observed in crystal structures of N,N-bis(trichloroacetyl) and N,N-bis(m-bromobenzoyl) gramicidin S. | 2001 Nov 1 |
|
| Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation. | 2001 Nov 6 |
|
| An immunohistological study of the localization characteristics of thymus and activation-regulated chemokine in the allergic inferior turbinate mucosa with reference to the effectiveness of trichloroacetic acid treatment. | 2001 Nov-Dec |
|
| New method for exopolysaccharide determination in culture broth using stirred ultrafiltration cells. | 2001 Oct |
|
| Glutathione stability in whole blood: effects of various deproteinizing acids. | 2001 Oct |
|
| Aerobic dehalogenation potentials of four bacterial species isolated from soil and sewage sludge. | 2001 Oct |
|
| Atomic emission method for total boron in blood during neutron-capture therapy. | 2001 Oct |
|
| Determining optimal surface roughness of TiO(2) blasted titanium implant material for attachment, proliferation and differentiation of cells derived from human mandibular alveolar bone. | 2001 Oct |
|
| The application of physiologically based pharmacokinetic modelling in the analysis of occupational exposure to perchloroethylene. | 2001 Oct 15 |
|
| Estimating internal phosphorus pools in macroalgae using radioactive phosphorus and trichloroacetic acid extracts. | 2001 Oct 15 |
|
| Trace determination of 1-octacosanol in rat plasma by solid-phase extraction with Tenax GC and capillary gas chromatography. | 2001 Oct 5 |
|
| Synthesis of a set of di- and tri-sulfated galabioses. | 2001 Oct 8 |
|
| Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice. | 2001 Sep |
|
| Determination of D- and L-aspartate in cell culturing medium, within cells of MPT1 cell line and in rat blood by a column-switching high-performance liquid chromatogrpahic method. | 2001 Sep 15 |
|
| Spectra interference between diquat and paraquat by second derivative spectrophotometry. | 2001 Sep 15 |
|
| Synthesis of a divalent glycoside of an alpha-galactosyl disaccharide epitope involved in the hyperacute rejection of xenotransplantation. | 2001 Sep 7 |
|
| Trichloroethylene, trichloroacetic acid, and dichloroacetic acid: do they affect fetal rat heart development? | 2001 Sep-Oct |
|
| The immunosuppressive activity of chemically modified lipopolysaccharide of Shigella sonnei. | 2002 Jan 1 |
|
| Sources, pathways, and relative risks of contaminants in surface water and groundwater: a perspective prepared for the Walkerton inquiry. | 2002 Jan 11 |
|
| Study of competitive binding of enantiomers to protein by affinity capillary electrochromatography. | 2002 Jan 15 |
|
| Succinate dehydrogenase and fumarate reductase from Escherichia coli. | 2002 Jan 17 |
Sample Use Guides
for melasma: 15% TCA peel
for anal high-grade squamous intraepithelial lesions: 80% TCA
Route of Administration:
Topical
Lymphocytes obtained from three healthy donors were exposed to 25, 50, and 100 μg/ml concentration of TCA separately. TCA exposure resulted in chromosomal anomalies and the formation of micronuclei in lymphocytes. Chromosome analysis revealed the dose-dependent and significant induction of Chromosomal aberration (CA).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 17 03:25:28 UTC 2022
by
admin
on
Sat Dec 17 03:25:28 UTC 2022
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| Record UNII |
2N76A3BRJ0
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
81001
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M11062
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650-51-1
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DTXSID6034924
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211-479-2
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6737
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23681045
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2N76A3BRJ0
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Sodium trichloroacetate
Created by
admin on Sat Dec 17 03:25:29 UTC 2022 , Edited by admin on Sat Dec 17 03:25:29 UTC 2022
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
