Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2Cl3O2.Na |
| Molecular Weight | 185.369 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[O-]C(=O)C(Cl)(Cl)Cl
InChI
InChIKey=SAQSTQBVENFSKT-UHFFFAOYSA-M
InChI=1S/C2HCl3O2.Na/c3-2(4,5)1(6)7;/h(H,6,7);/q;+1/p-1
| Molecular Formula | C2Cl3O2 |
| Molecular Weight | 162.379 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Trichloroacetic acid (TCA; TCAA) is a chemical used in skin peel formulations. It is more frequently used for lighter skin and is less used on darker skin because of the higher risks of scarring, as well as post-peel dyschromias. Low concentrations, 10-35% is preferred for skin peel formulations so that it only reaches the upper papillary dermis. Topical TCA is an efficacious treatment of internal anal high-grade squamous intraepithelial lesions (HSIL). Advantages of TCA for this recurrent disease process include low cost, no requirement for special equipment beyond that for high-resolution anoscopy, and painless application procedure.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses. | 2001 |
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| The [15N]methacetin liver function test characterizes multicomponent exposure of children in industrially polluted regions. | 2001 |
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| Synthesis of disaccharides related to the mycobacterial arabinogalactan. | 2001 |
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| A multi media load model for the Baltic Sea. | 2001 |
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| Regulation by gonadal steroids of estrogen and progesterone receptors along the reproductive tract in female lambs. | 2001 |
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| Biochemical, electron microscopic and immunohistological observations of cationic detergent-extracted cells: detection and improved preservation of microextensions and ultramicroextensions. | 2001 |
|
| Imiquimod for the treatment of genital warts: a quantitative systematic review. | 2001 |
|
| Site-specific mutations of FtsZ--effects on GTPase and in vitro assembly. | 2001 |
|
| ATP inhibits insulin-degrading enzyme activity. | 2001 Apr |
|
| Effects of the matrix and sample preparation on the determination of fluoroquinolone residues in animal tissues. | 2001 Apr 20 |
|
| Sample preparation for residue determination of gentamicin and neomycin by liquid chromatography. | 2001 Apr 20 |
|
| Molluscum contagiosum in herpes zoster scars. | 2001 Aug |
|
| [Endogenic intoxication markers: data from capillary electrophoresis of trichloroacetic acid supernatant]. | 2001 Aug |
|
| New formulation of chemical peeling agent: histological evaluation in sun-damaged skin model in hairless mice. | 2001 Aug |
|
| Photosonochemical degradation of trichloroacetic acid in aqueous solution. | 2001 Aug |
|
| Stability of a cisplatin-chondroitin sulfate A complex in plasma and kidney in terms of protein binding. | 2001 Aug |
|
| Production of hyaluronan and chondroitin sulphate proteoglycans from human arterial smooth muscle--the effect of glucose, insulin, IGF-I or growth hormone. | 2001 Aug |
|
| Kinetics in the pre-steady state of the formation of cystines in ribonucleoside diphosphate reductase: evidence for an asymmetric complex. | 2001 Aug 14 |
|
| Assay of 2,3-dihydroxybenzoic acid and related compounds in plant materials by high-performance liquid chromatography. | 2001 Aug 24 |
|
| Factors involved in clearance of genital warts. | 2001 Dec |
|
| Feasibility of iodine-125 labeled anti-human hemoglobin antibody in the detection of bleeding sites from the large bowel-A preliminary study. | 2001 Jul |
|
| A simple HPLC method for the determination of the mycotoxins ochratoxin A and B in blood serum of swine. | 2001 Jul |
|
| Possible explanation of the disparity between the in vitro and in vivo measurements of Rubisco activity: a study in loblolly pine grown in elevated pCO2. | 2001 Jul |
|
| Investigation of uptake, translocation and fate of trichloroacetic acid in Norway spruce (Picea abies/L./Karst.) using 14C-labelling. | 2001 Jul |
|
| Simplified analysis of contaminant rejection during ground- and surface water nanofiltration under the information collection rule. | 2001 Jul |
|
| A new glycogen synthase activity ratio in skeletal muscle: effects of exercise and insulin. | 2001 Jul 13 |
|
| Sensitive and simple determination of mannitol in human brain tissues by gas chromatography-mass spectrometry. | 2001 Jul 5 |
|
| Isolation and specific detection of two major schistosoma gut-associated circulating antigens. | 2001 Jun |
|
| Factors influencing attachment of thermophilic bacilli to stainless steel. | 2001 Jun |
|
| The disruption of a gene encoding a putative arylesterase impairs pyruvate dehydrogenase complex activity and nitrogen fixation in Sinorhizobium meliloti. | 2001 Jun |
|
| Reduction of haloacetic acids by Fe0: implications for treatment and fate. | 2001 Jun 1 |
|
| Purification and characterization of a natural agglutinin in the hemolymph of the prawn Penaeus indicus H. Milne Edwards. | 2001 May |
|
| The treatment of eruptive syringomas in an African American patient with a combination of trichloroacetic acid and CO2 laser destruction. | 2001 May |
|
| Lamotrigine analysis in blood and brain by high-performance liquid chromatography. | 2001 May 5 |
|
| A facile and effective synthesis of alpha-(1-->6)-linked mannose di-, tri-, tetra-, hexa-, octa-, and dodecasaccharides, and beta-(1-->6)-linked glucose di-, tri-, tetra-, hexa-, and octasaccharides using sugar trichloroacetimidates as the donors and unprotected or partially protected glycosides as the acceptors. | 2001 May 8 |
|
| Outcome of 22 cases of perforated tympanic membrane caused by otomycosis. | 2001 Nov |
|
| Differences in yields of microbial crude protein from in vitro fermentation of carbohydrates. | 2001 Nov |
|
| Antibodies against Streptococcus agalactiae proteins c(alpha) and R4 in sera from pregnant women from Norway and Zimbabwe. | 2001 Nov |
|
| Redundancy of mammalian proteasome beta subunit function during endoplasmic reticulum associated degradation. | 2001 Nov 6 |
|
| New method for exopolysaccharide determination in culture broth using stirred ultrafiltration cells. | 2001 Oct |
|
| Aerobic dehalogenation potentials of four bacterial species isolated from soil and sewage sludge. | 2001 Oct |
|
| Atomic emission method for total boron in blood during neutron-capture therapy. | 2001 Oct |
|
| Determining optimal surface roughness of TiO(2) blasted titanium implant material for attachment, proliferation and differentiation of cells derived from human mandibular alveolar bone. | 2001 Oct |
|
| Estimating internal phosphorus pools in macroalgae using radioactive phosphorus and trichloroacetic acid extracts. | 2001 Oct 15 |
|
| Synthesis of a set of di- and tri-sulfated galabioses. | 2001 Oct 8 |
|
| Effect of chloroform on dichloroacetic acid and trichloroacetic acid-induced hypomethylation and expression of the c-myc gene and on their promotion of liver and kidney tumors in mice. | 2001 Sep |
|
| Spectra interference between diquat and paraquat by second derivative spectrophotometry. | 2001 Sep 15 |
|
| Synthesis of a divalent glycoside of an alpha-galactosyl disaccharide epitope involved in the hyperacute rejection of xenotransplantation. | 2001 Sep 7 |
|
| Sources, pathways, and relative risks of contaminants in surface water and groundwater: a perspective prepared for the Walkerton inquiry. | 2002 Jan 11 |
|
| Succinate dehydrogenase and fumarate reductase from Escherichia coli. | 2002 Jan 17 |
Sample Use Guides
for melasma: 15% TCA peel
for anal high-grade squamous intraepithelial lesions: 80% TCA
Route of Administration:
Topical
Lymphocytes obtained from three healthy donors were exposed to 25, 50, and 100 μg/ml concentration of TCA separately. TCA exposure resulted in chromosomal anomalies and the formation of micronuclei in lymphocytes. Chromosome analysis revealed the dose-dependent and significant induction of Chromosomal aberration (CA).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 20:17:07 GMT 2023
by
admin
on
Sat Dec 16 20:17:07 GMT 2023
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| Record UNII |
2N76A3BRJ0
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| Record Status |
Validated (UNII)
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| Record Version |
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EPA PESTICIDE CODE |
81001
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m11062
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650-51-1
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DTXSID6034924
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211-479-2
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6737
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23681045
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2N76A3BRJ0
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Sodium trichloroacetate
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| Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
