PAFENOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H31N3O3
Molecular Weight	337.457
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NCC(O)COC1=CC=C(CCNC(=O)NC(C)C)C=C1

InChI

InChIKey=PKWZWSXSCKVUJB-UHFFFAOYSA-N

InChI=1S/C18H31N3O3/c1-13(2)20-11-16(22)12-24-17-7-5-15(6-8-17)9-10-19-18(23)21-14(3)4/h5-8,13-14,16,20,22H,9-12H2,1-4H3,(H2,19,21,23)

HIDE SMILES / InChI

Molecular Formula	C18H31N3O3
Molecular Weight	337.457
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6129091 | https://adisinsight.springer.com/drugs/800002399

Pafenolol is a beta 1 selective adrenoceptor blocker that was studied in phase I clinical trial in Sweden for the treatment of arrhythmia. However, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile.	1993-06	8100633
Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat.	1993-05	8100631
Pafenolol in hypertension: a double-blind randomized trial of a new beta 1-selective adrenoceptor blocker.	1986-01-01	2419693
Pafenolol, a highly selective beta 1-adrenoceptor-antagonist, in asthmatic patients: interaction with terbutaline.	1983-01	6129091

Patents

Sample Use Guides

In Vivo Use Guide

Intravenous pafenolol (5 mg and 7.5 mg), metoprolol (15 mg), and saline were given double-blind at random and thereafter four increasing doses of terbutaline were given intravenously to seven asthmatic patients with reproducible reversibility of airways obstruction.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:05:22 GMT 2025` Edited by `admin` on `Mon Mar 31 18:05:22 GMT 2025`
Record UNII	5AEP5YJ9MZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

UREA, N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)-, (±)-

Preferred Name

English

PAFENOLOL

Official Name

English

UREA, N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)-

Systematic Name

English

Pafenolol [WHO-DD]

Common Name

English

(±)-1-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)-3-ISOPROPYLUREA

Common Name

English

pafenolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576