PAFENOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H31N3O3
Molecular Weight	337.457
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NCC(O)COC1=CC=C(CCNC(=O)NC(C)C)C=C1

InChI

InChIKey=PKWZWSXSCKVUJB-UHFFFAOYSA-N

InChI=1S/C18H31N3O3/c1-13(2)20-11-16(22)12-24-17-7-5-15(6-8-17)9-10-19-18(23)21-14(3)4/h5-8,13-14,16,20,22H,9-12H2,1-4H3,(H2,19,21,23)

HIDE SMILES / InChI

Molecular Formula	C18H31N3O3
Molecular Weight	337.457
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6129091 | https://adisinsight.springer.com/drugs/800002399

Pafenolol is a beta 1 selective adrenoceptor blocker that was studied in phase I clinical trial in Sweden for the treatment of arrhythmia. However, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Pafenolol, a highly selective beta 1-adrenoceptor-antagonist, in asthmatic patients: interaction with terbutaline.	1983 Jan	6129091
Pafenolol in hypertension: a double-blind randomized trial of a new beta 1-selective adrenoceptor blocker.	1986 Jan-Feb	2419693
Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile.	1993 Jun	8100633
Dose-dependent intestinal absorption and significant intestinal excretion (exsorption) of the beta-blocker pafenolol in the rat.	1993 May	8100631

Patents

Sample Use Guides

In Vivo Use Guide

Intravenous pafenolol (5 mg and 7.5 mg), metoprolol (15 mg), and saline were given double-blind at random and thereafter four increasing doses of terbutaline were given intravenously to seven asthmatic patients with reproducible reversibility of airways obstruction.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:40:58 GMT 2023` Edited by `admin` on `Fri Dec 15 15:40:58 GMT 2023`
Record UNII	5AEP5YJ9MZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PAFENOLOL

Official Name

English

UREA, N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)-

Systematic Name

English

UREA, N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)-, (±)-

Common Name

English

Pafenolol [WHO-DD]

Common Name

English

(±)-1-(P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENETHYL)-3-ISOPROPYLUREA

Common Name

English

pafenolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576