U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C18H31N3O3
Molecular Weight 337.457
Optical Activity ( - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PAFENOLOL, (-)-

SMILES

CC(C)NCC(O)COC1=CC=C(CCNC(=O)NC(C)C)C=C1

InChI

InChIKey=PKWZWSXSCKVUJB-UHFFFAOYSA-N
InChI=1S/C18H31N3O3/c1-13(2)20-11-16(22)12-24-17-7-5-15(6-8-17)9-10-19-18(23)21-14(3)4/h5-8,13-14,16,20,22H,9-12H2,1-4H3,(H2,19,21,23)

HIDE SMILES / InChI

Molecular Formula C18H31N3O3
Molecular Weight 337.457
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Pafenolol is a beta 1 selective adrenoceptor blocker that was studied in phase I clinical trial in Sweden for the treatment of arrhythmia. However, this study was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile.
1993 Jun
Patents

Sample Use Guides

Intravenous pafenolol (5 mg and 7.5 mg), metoprolol (15 mg), and saline were given double-blind at random and thereafter four increasing doses of terbutaline were given intravenously to seven asthmatic patients with reproducible reversibility of airways obstruction.
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:19:53 GMT 2023
Edited
by admin
on Sat Dec 16 10:19:53 GMT 2023
Record UNII
QW8T7NK8X6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PAFENOLOL, (-)-
Common Name English
UREA, N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)-, (-)-
Systematic Name English
(-)-N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)UREA
Common Name English
Code System Code Type Description
CAS
178968-84-8
Created by admin on Sat Dec 16 10:19:54 GMT 2023 , Edited by admin on Sat Dec 16 10:19:54 GMT 2023
PRIMARY
FDA UNII
QW8T7NK8X6
Created by admin on Sat Dec 16 10:19:54 GMT 2023 , Edited by admin on Sat Dec 16 10:19:54 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER
ENANTIOMER -> ENANTIOMER