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Details

Stereochemistry UNKNOWN
Molecular Formula C18H31N3O3
Molecular Weight 337.457
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PAFENOLOL, (+)-

SMILES

CC(C)NCC(O)COC1=CC=C(CCNC(=O)NC(C)C)C=C1

InChI

InChIKey=PKWZWSXSCKVUJB-UHFFFAOYSA-N
InChI=1S/C18H31N3O3/c1-13(2)20-11-16(22)12-24-17-7-5-15(6-8-17)9-10-19-18(23)21-14(3)4/h5-8,13-14,16,20,22H,9-12H2,1-4H3,(H2,19,21,23)

HIDE SMILES / InChI

Molecular Formula C18H31N3O3
Molecular Weight 337.457
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Pafenolol is a beta 1 selective adrenoceptor blocker that was studied in phase I clinical trial in Sweden for the treatment of arrhythmia. However, this study was discontinued.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

Intravenous pafenolol (5 mg and 7.5 mg), metoprolol (15 mg), and saline were given double-blind at random and thereafter four increasing doses of terbutaline were given intravenously to seven asthmatic patients with reproducible reversibility of airways obstruction.
Route of Administration: Intravenous
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:19:53 GMT 2023
Edited
by admin
on Sat Dec 16 10:19:53 GMT 2023
Record UNII
E6X8CBK4RR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PAFENOLOL, (+)-
Common Name English
UREA, N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)-, (+)-
Systematic Name English
(+)-N-(2-(4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)PHENYL)ETHYL)-N'-(1-METHYLETHYL)UREA
Common Name English
Code System Code Type Description
FDA UNII
E6X8CBK4RR
Created by admin on Sat Dec 16 10:19:53 GMT 2023 , Edited by admin on Sat Dec 16 10:19:53 GMT 2023
PRIMARY
CAS
178968-79-1
Created by admin on Sat Dec 16 10:19:53 GMT 2023 , Edited by admin on Sat Dec 16 10:19:53 GMT 2023
PRIMARY
PUBCHEM
71144
Created by admin on Sat Dec 16 10:19:53 GMT 2023 , Edited by admin on Sat Dec 16 10:19:53 GMT 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> ENANTIOMER
RACEMATE -> ENANTIOMER