SENAZODAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H14N4O
Molecular Weight	266.2979
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O=C1CCC(=NN1)C2=CC=C(NC3=CC=NC=C3)C=C2

InChI

InChIKey=XEBRQQXYWHMEQW-UHFFFAOYSA-N

InChI=1S/C15H14N4O/c20-15-6-5-14(18-19-15)11-1-3-12(4-2-11)17-13-7-9-16-10-8-13/h1-4,7-10H,5-6H2,(H,16,17)(H,19,20)

HIDE SMILES / InChI

Molecular Formula	C15H14N4O
Molecular Weight	266.2979
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7687707 | https://www.ncbi.nlm.nih.gov/pubmed/12079634 | https://adisinsight.springer.com/drugs/800000316

Senazodan (previously known as MCI 154), a positive inotropic agent that inhibits phosphodiesterase III and possesses a vasodilating property. Senazodan was studied in the phase II clinical trial in Japan in patients with acute heart failure. However, this study was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Stimulation of myocardium during reperfusion injury by a new inotrope-vasodilator agent, MCI-154.	1987	3443426
Effects of MCI-154 on Ca2+ activation of skinned human myocardium.	1989 Jun 20	2776833
Inotropic therapy of heart failure. Editorial comments on: Vasodilation and mechanoenergetic inefficiency dominates the effect of the "Ca2+ sensitizer" MCI-154 in intact pigs.	2002 May	12079634
The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C.	2018 Dec	30417133

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:21 GMT 2023` Edited by `admin` on `Fri Dec 15 16:28:21 GMT 2023`
Record UNII	427L2I2KIM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SENAZODAN

Official Name

English

senazodan [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C744