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Details

Stereochemistry ACHIRAL
Molecular Formula C15H14N4O.ClH
Molecular Weight 302.759
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SENAZODAN HYDROCHLORIDE

SMILES

Cl.O=C1CCC(=NN1)C2=CC=C(NC3=CC=NC=C3)C=C2

InChI

InChIKey=NYQCKFLLTCINSJ-UHFFFAOYSA-N
InChI=1S/C15H14N4O.ClH/c20-15-6-5-14(18-19-15)11-1-3-12(4-2-11)17-13-7-9-16-10-8-13;/h1-4,7-10H,5-6H2,(H,16,17)(H,19,20);1H

HIDE SMILES / InChI
Molecular Formula C15H14N4O
Molecular Weight 266.2979
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Senazodan (previously known as MCI 154), a positive inotropic agent that inhibits phosphodiesterase III and possesses a vasodilating property. Senazodan was studied in the phase II clinical trial in Japan in patients with acute heart failure. However, this study was discontinued.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
High selectivity for inhibition of phosphodiesterase III and positive inotropic effects of MCI-154 in guinea pig myocardium.
1993 Jun
The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C.
2018 Dec
Substance Class Chemical
Created
by admin
on Fri Dec 15 18:08:33 GMT 2023
Edited
by admin
on Fri Dec 15 18:08:33 GMT 2023
Record UNII
8AQJ5MIM3P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SENAZODAN HYDROCHLORIDE
Common Name English
3(2H)-PYRIDAZINONE, 4,5-DIHYDRO-6-(4-(4-PYRIDINYLAMINO)PHENYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
MCI-154
Code English
Code System Code Type Description
FDA UNII
8AQJ5MIM3P
Created by admin on Fri Dec 15 18:08:33 GMT 2023 , Edited by admin on Fri Dec 15 18:08:33 GMT 2023
PRIMARY
PUBCHEM
123941
Created by admin on Fri Dec 15 18:08:33 GMT 2023 , Edited by admin on Fri Dec 15 18:08:33 GMT 2023
PRIMARY
EPA CompTox
DTXSID00913328
Created by admin on Fri Dec 15 18:08:33 GMT 2023 , Edited by admin on Fri Dec 15 18:08:33 GMT 2023
PRIMARY
CAS
98326-33-1
Created by admin on Fri Dec 15 18:08:33 GMT 2023 , Edited by admin on Fri Dec 15 18:08:33 GMT 2023
PRIMARY
Related Record Type Details
Structure of SENAZODAN HYDROCHLORIDE TRIHYDRATE
SOLVATE->ANHYDROUS
Structure of SENAZODAN
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of SENAZODAN
ACTIVE MOIETY
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